Telomerase is Significant as an Early Diagnostic Marker and Therapeutic Target

2013 ◽  
pp. 757-764
Author(s):  
Lian Duan ◽  
Nan Wang ◽  
Xinghua Liao ◽  
Jun Zhou ◽  
Dalin lu ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Diagnostic Marker ◽  
Early Diagnostic

Comparative evaluation of MCP gene in worldwide strains of Megalocytivirus (Iridoviridae family) for early diagnostic marker

2017 ◽  
Vol 41 (1) ◽  
pp. 105-116
Author(s):  
A Mishra ◽  
G-H Nam ◽  
J-A Gim ◽  
H-E Lee ◽  
A Jo ◽  
...  
Keyword(s):  
Comparative Evaluation ◽  
Diagnostic Marker ◽  
Early Diagnostic

Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer

The Prostate ◽  
2017 ◽  
Vol 77 (15) ◽  
pp. 1499-1511 ◽  
Author(s):  
Sergio Pedraza-Arévalo ◽  
Daniel Hormaechea-Agulla ◽  
Enrique Gómez-Gómez ◽  
María J. Requena ◽  
Luke A. Selth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Target ◽  
Diagnostic Marker ◽  
Somatostatin Receptor ◽  
Receptor Subtype

P2-176: Are cortical sources of auditory oddball event-related potentials an early diagnostic marker of Alzheimer's disease?

2015 ◽  
Vol 11 (7S_Part_12) ◽  
pp. P559-P559
Author(s):  
Claudio Babiloni ◽  
Claudio Del Percio ◽  
Nicola Marzano ◽  
Susanna Cordone ◽  
Giuseppe Noce ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Diagnostic Marker ◽  
Event Related Potentials ◽  
Auditory Oddball ◽  
Cortical Sources ◽  
Related Potentials ◽  
Early Diagnostic

scholarly journals Levels of CEACAM6 in Peripheral Blood Are Elevated in Patients with Plasma Cell Disorders: A Potential New Diagnostic Marker and a New Therapeutic Target?

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
N. Steiner ◽  
R. Hajek ◽  
D. Nachbaur ◽  
B. Borjan ◽  
S. Sevcikova ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Plasma Cell ◽  
Adhesion Molecule ◽  
Peripheral Blood ◽  
Therapeutic Target ◽  
Plasma Levels ◽  
Diagnostic Marker ◽  
Healthy Controls ◽  
Plasma Cell Disorders

Introduction. The prognosis of multiple myeloma is still unfavorable due to inherent characteristics of the disease and the often-delayed diagnosis due to widespread and unspecific symptoms such as back pain and fatigue. Therefore, a simple diagnostic blood test would be helpful to speed up the diagnostic procedure in such patients (pts.). Here, we evaluated the diagnostic value of plasma levels of carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) in the peripheral blood and bone marrow of pts. with plasma cell disorders and in healthy controls. Materials and Methods. Immunoreactive CEACAM6 was determined in the peripheral blood and bone marrow (n=95/100) of pts. with monoclonal gammopathy of unknown significance (MGUS: 28/37), newly diagnosed multiple myeloma (NDMM: 42/40), and relapsed/refractory multiple myeloma (RRMM: 25/23) by sandwich ELISA. Results. Median CEACAM6 levels in the peripheral blood of pts. with plasma cell disorders were significantly higher than those of healthy controls (healthy controls: 15.2 pg/ml (12.1-17.1); MGUS: 19.0 pg/ml (16.4-22.5); NDMM: 18.0 pg/ml (13.4-21.2); and RRMM: 18.9 pg/ml (15.2-21.5); p<0.001). Plasma levels of CEACAM6 discriminated healthy subjects from MGUS/NDMM pts. (AUC=0.71, 95% CI: 0.6-0.8); i.e., a CEACAM6 level>17.3 pg/ml has an 82% (95% CI: 70-90) predictive probability for the identification of MGUS or NDMM. Moreover, CEACAM6 levels in the bone marrow were significantly higher in RRMM pts. than in NDMM pts. (p=0.04), suggesting a role of this molecule in disease progression. Conclusion. CEACAM6 plasma levels can noninvasively identify pts. with a plasma cell disorder and should be evaluated prospectively as a potential diagnostic marker. Moreover, due to high CEACAM6 levels in the bone marrow in RRMM pts., this adhesion molecule might be a therapeutic target in multiple myeloma pts.

Utility of procalcitonin as an early diagnostic marker of bacteremia in individuals with Periodontitis Stage II and III

2020 ◽  
Author(s):  
Ranjitha Mohan ◽  
Srirangarajan ◽  
Ravi J. Rao ◽  
Srikumar Prabhu ◽  
Vinaya Rudresh
Keyword(s):  
Diagnostic Marker ◽  
Stage Ii ◽  
Early Diagnostic

scholarly journals KLK10 exon 3 unmethylated PCR product concentration: a new potential early diagnostic marker in ovarian cancer? - A pilot study

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Mustafa A. El Sherbini ◽  
Amal A. Mansour ◽  
Maha M. Sallam ◽  
Emtiaz A. Shaban ◽  
Zeinab A. Shehab ElDin ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Pilot Study ◽  
Diagnostic Marker ◽  
Product Concentration ◽  
Pcr Product ◽  
Early Diagnostic
Sign in / Sign up

Export Citation Format

Share Document