FDG: biochemical concept and radiochemical synthesis

2000 ◽  
pp. 55-65
Author(s):  
W. Hamkens ◽  
F. Rösch
Keyword(s):  
Radiochemical Synthesis

scholarly journals Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[11C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS

2021 ◽  
Vol 12 (4) ◽  
pp. 756-765
Author(s):  
Nicolas J. Guehl ◽  
Ramesh Neelamegam ◽  
Yu-Peng Zhou ◽  
Sung-Hyun Moon ◽  
Maeva Dhaynaut ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Pet Tracer ◽  
Radiochemical Synthesis

ChemInform Abstract: RADIOCHEMICAL SYNTHESIS OF BIS(DIMETHYLCHLOROSILYL)- AND BIS(METHYLDICHLOROSILYL)BENZENE

1977 ◽  
Vol 8 (36) ◽  
pp. no-no
Author(s):  
B. I. VAINSHTEIN ◽  
L. P. BOGOVTSEVA ◽  
E. A. VAKS
Keyword(s):  
Radiochemical Synthesis

scholarly journals Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides)

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 704
Author(s):  
Alessandra Cavaliere ◽  
Katrin C. Probst ◽  
Stephen J. Paisey ◽  
Christopher Marshall ◽  
Abdul K. H. Dheere ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Pet Imaging ◽  
Early Stage ◽  
Proof Of Concept ◽  
Synthesis Time ◽  
Positron Emission ◽  
Anti Cancer ◽  
Radiochemical Yields ◽  
Radiochemical Synthesis

Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success. Despite the translation of ProTide technology into the clinic, there remain unresolved in vivo pharmacokinetic and pharmacodynamic questions. Positron Emission Tomography (PET) imaging using [18F]-labelled model ProTides could directly address key mechanistic questions and predict response to ProTide therapy. Here we report the first radiochemical synthesis of [18F]ProTides as novel probes for PET imaging. As a proof of concept, two chemically distinct radiolabelled ProTides have been synthesized as models of 3′- and 2′-fluorinated ProTides following different radiosynthetic approaches. The 3′-[18F]FLT ProTide was obtained via a late stage [18F]fluorination in radiochemical yields (RCY) of 15–30% (n = 5, decay-corrected from end of bombardment (EoB)), with high radiochemical purities (97%) and molar activities of 56 GBq/μmol (total synthesis time of 130 min.). The 2′-[18F]FIAU ProTide was obtained via an early stage [18F]fluorination approach with an RCY of 1–5% (n = 7, decay-corrected from EoB), with high radiochemical purities (98%) and molar activities of 53 GBq/μmol (total synthesis time of 240 min).

RADIOCHEMICAL SYNTHESIS OF TRIIODOTHYRONINE

The Lancet ◽  
1960 ◽  
Vol 276 (7159) ◽  
pp. 1090
Author(s):  
J.C Charlton
Keyword(s):  
Radiochemical Synthesis

Radiochemical synthesis of [123I]2-iodo-lisuride for dopamine D2-receptor studies

1996 ◽  
Vol 23 (3) ◽  
pp. 373-376 ◽  
Author(s):  
Dirk Bier ◽  
Klaus Dutschka ◽  
E.Joachim Knust
Keyword(s):  
Dopamine D2 Receptor ◽  
D2 Receptor ◽  
Dopamine D2 ◽  
Radiochemical Synthesis

Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener

2002 ◽  
Vol 29 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Dale O Kiesewetter ◽  
Elaine M Jagoda ◽  
John E Starrett ◽  
Valentin K Gribkoff ◽  
Piyasena Hewawasam ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Potassium Channel Opener ◽  
Channel Opener ◽  
Radiochemical Synthesis

Radiochemical Synthesis of Au/Iron-oxide Composite Nanoparticles Using PEG

2007 ◽  
Vol 1064 ◽  
Author(s):  
Satoshi Seino ◽  
Takuya Kinoshita ◽  
Juinichi Iida ◽  
Yujin Shibata ◽  
Takashi Nakagawa ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Iron Oxide ◽  
Average Diameter ◽  
Composite Nanoparticles ◽  
Polyethylene Glycols ◽  
Oxide Nanoparticles ◽  
Gold Particles ◽  
Adsorbed Sulfur ◽  
Sulfur Containing ◽  
Radiochemical Synthesis

ABSTRACTComposite nanoparticles consisting of gold and iron-oxide were radiochemically synthesized in aqueous solution systems by using polyethylene glycols. The gold particles with average diameter of 3 nm were firmly immobilized on the surface of the support iron-oxide nanoparticles. The composite nanoparticles specifically adsorbed sulfur-containing amino acids by a Au-S bonding.

Radiochemical synthesis part II The preparation of14C-labeled juvenile hormone

1971 ◽  
Vol 7 (3) ◽  
pp. 331-339 ◽  
Author(s):  
W. Hafferl ◽  
R. Zurflüh ◽  
L. Dunham
Keyword(s):  
Juvenile Hormone ◽  
Radiochemical Synthesis
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