Inhibition of the MHC Class II Antigen Presentation Pathway by Human Cytomegalovirus

2002 ◽  
pp. 101-115 ◽  
Author(s):  
D. C. Johnson ◽  
N. R. Hegde
Keyword(s):  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Human Cytomegalovirus ◽  
Class Ii ◽  
Antigen Presentation Pathway ◽  
Presentation Pathway ◽  
Class Ii Antigen ◽  
Mhc Class Ii Antigen

HLA-DM and the MHC class II antigen presentation pathway

1999 ◽  
Vol 20 (2) ◽  
pp. 195-205 ◽  
Author(s):  
Peter E. Jensen ◽  
Dominique A. Weber ◽  
Wesley P. Thayer ◽  
Xinjian Chen ◽  
Chin T. Dao
Keyword(s):  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Antigen Presentation Pathway ◽  
Presentation Pathway ◽  
Class Ii Antigen ◽  
Mhc Class Ii Antigen

scholarly journals High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma

2019 ◽  
Vol 203 (10) ◽  
pp. 2577-2587 ◽  
Author(s):  
Kenneth H. Buetow ◽  
Lydia R. Meador ◽  
Hari Menon ◽  
Yih-Kuang Lu ◽  
Jacob Brill ◽  
...  
Keyword(s):  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Antigen Presentation Pathway ◽  
Presentation Pathway ◽  
Class Ii Antigen ◽  
Mhc Class Ii Antigen

scholarly journals The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0183594 ◽  
Author(s):  
Justin Lee ◽  
Hanson Tam ◽  
Lital Adler ◽  
Alexandra Ilstad-Minnihan ◽  
Claudia Macaubas ◽  
...  
Keyword(s):  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Human Monocytes ◽  
Antigen Presentation Pathway ◽  
Presentation Pathway ◽  
Class Ii Antigen ◽  
Mhc Class Ii Antigen

scholarly journals Targeting the MHC Class II antigen presentation pathway in cancer immunotherapy

2012 ◽  
Vol 1 (6) ◽  
pp. 908-916 ◽  
Author(s):  
Jacques Thibodeau ◽  
Marie-Claude Bourgeois-Daigneault ◽  
Réjean Lapointe
Keyword(s):  
Antigen Presentation ◽  
Cancer Immunotherapy ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Antigen Presentation Pathway ◽  
Presentation Pathway ◽  
Class Ii Antigen ◽  
Mhc Class Ii Antigen

scholarly journals H2-M and H2-O as Targeting Vehicles for the MHC Class II Processing Compartment Promote Antigen-Specific CD4+ T Cell Activation

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1053
Author(s):  
Lucia Lapazio ◽  
Monika Braun ◽  
Kaj Grandien
Keyword(s):  
T Cell ◽  
Mhc Class Ii ◽  
T Cell Activation ◽  
Cell Activation ◽  
Class Ii ◽  
Cd4 T Cell ◽  
Antigen Presentation Pathway ◽  
Presentation Pathway ◽  
Class Ii Antigen ◽  
Mhc Class Ii Antigen

CD8 and CD4 T cell activation are both required for a strong and long-lasting T cell immune response. Endogenously expressed proteins are readily processed by the MHC class I antigen presentation pathway, enabling activation of CD8+ T cells. However, the MHC class II antigen presentation pathway, necessary for CD4+ T cell activation, is generally not sufficiently accessible to endogenously expressed proteins, limiting the efficiency of mRNA- or DNA-based vaccines. In the current study, we have evaluated the feasibility of using antigen sequences fused to sequences derived from the H2-M and H2-O proteins, two complexes known to participate in MHC class II antigen processing, for the enhancement of CD4 T-cell activation. We analyzed T cell activation after genetic immunization with mRNA-encoding fusion proteins with the model antigen ovalbumin and sequences derived from H2-M or H2-O. Our results show that H2-M- or H2-O-derived sequences robustly improve antigen-specific CD4 T-cell activation when fused to the antigen of interest and suggest that the approach could be used to improve the efficiency of mRNA- or DNA-based vaccines.

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