Resistance to Causes of Death: A Study of Cancer Mortality Resistance in the Oldest Old

1999 ◽  
pp. 61-71 ◽  
Author(s):  
D. W. E. Smith
BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
I. Zapata ◽  
M. Alvarez ◽  
R. Hidalgo ◽  
B. Pajares ◽  
M. J. Garcia-Anaya ◽  
...  

Abstract Background To investigate the incidence of non-cancer mortalities and prognostic factors associated with competitive causes of death in a homogeneous cohort of patients with locally advanced head and neck cancer treated with radiotherapy and systemic treatment. Methods This study included 284 patients with locally advanced head and neck cancer treated with radiotherapy and systemic treatment between 2005 and 2017. The cumulative incidence of death associated with tumour, second tumours, treatment, side effects and comorbidity was calculated. A Fine and Gray regression model was used to investigate factors associated with cancer and competitive mortality. Results The cumulative incidence of tumoral death at 5 and 10 years were 35 and 47% respectively, whereas the cumulative incidence of competitive mortality were 10 and 12% respectively. In the multivariate analysis, age and comorbidity were independent factors for non-cancer mortality. Patients with a high risk of non-cancer mortality presented a cumulative incidence of 17.3% at 5 years and 18.4% at 10 years. Conclusions This study demonstrated a high incidence of competing mortality in older patients with comorbidities. Non-cancer deaths should be considered when selecting patients for combination therapies and in the study design ofclinical trials.


2014 ◽  
Vol 54 (1) ◽  
pp. 115-123 ◽  
Author(s):  
Adalbjorg Kristbjornsdottir ◽  
Vilhjalmur Rafnsson

2014 ◽  
Vol 22 (1) ◽  
pp. 86-92
Author(s):  
Patricia de Moraes Mello Boccolini ◽  
Carmen Ildes Rodrigues Froes Asmus ◽  
Juliana de Rezende Chrisman ◽  
Volney de Magalhães Câmara ◽  
Steven B. Markowitz ◽  
...  

INTRODUCTION: Pesticide consumption is very high in Brazil.OBJECTIVE: The present study investigated the stomach cancer mortality among Brazilian agricultural workers in Rio de Janeiro state.METHODS: In this case-control study, cases were individuals of both genders, aged ≥20 years, for whom cause of death was ascertained as stomach cancer. Controls were individuals with causes of death other than neoplasm and diseases of the digestive system. Crude and adjusted analyses were carried out. Stomach cancer mortality risk was then estimated for the agricultural workers according to the pesticide expenditures per municipality.RESULTS: Agricultural workers showed an elevated risk of stomach cancer mortality (adjusted OR=1.42; 95%CI: 1.33-1.78). This risk was higher among male workers, aged 50-69 years, white, and among workers with 1-7 years of education. Results also showed increasing stomach cancer mortality along with the increase of pesticide expenditure per agricultural worker.CONCLUSION: Stomach cancer risk among agricultural workers may be associated with pesticide exposure.


Aging ◽  
2020 ◽  
Vol 12 (17) ◽  
pp. 16744-16758
Author(s):  
Dana Hashim ◽  
Greta Carioli ◽  
Matteo Malvezzi ◽  
Paola Bertuccio ◽  
Samuel Waxman ◽  
...  
Keyword(s):  

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13610-e13610
Author(s):  
Joao Paulo Reis Neto ◽  
Juliana Martinho Busch ◽  
Stephen D. Stefani

e13610 Background: Cancer is the second leading cause of death worldwide. From 2014 to 2015 Brazil estimated more than 500,000 new cases of cancer, which placed the country among those with the highest cancer incidence. This study evaluates the 10-year evolution of mortality rates due to all causes and cancer and to estimate the potential years of life lost (PYLL) in beneficiaries of health plan, according to sex, age and geographic region. Methods: Retrospective cross-sectional, descriptive study evaluated the causes of death, between 2008 and 2017, by sex and age groups, for all causes (AC) and cancer (CA) data from the health insurance system. The information on the death certificates (DC) was coded according to the ICD-10. Age was stratified into groups: up to 49 years, 50–59 years, 60–69 years, 70–79 years and 80 years or more. Data were analyzed by checking the proportions and mortality rates (MR), grouped into two five-year periods, 2008-2012 (P1) e 2013-2017 (P2). Annual MR per 100,000 population was estimated using the direct method and proportional mortality rates (PMR). To calculate the potential years of life lost (PYLL) the upper limit was 76 years old. The avoidable MR was also analyzed for individuals up to 75 years and cancer. Microsoft Excel v2010 and Qlik Sense v13.21 were used to analyze data and statistics. Results: 5,779 deaths were analyzed, 4,447 in men (77.0%, average 70.1 years) and 1,332 women (33%, 75.9 years). Cancer was the second leading cause of death (n = 953, PMR 16.5%), behind cardiovascular disease (n = 1,662 PMR 28.8%). The major crude death rate per 100,000 was due circulatory system diseases (347), followed by cancer (199) and respiratory system diseases (110). The highest cancer MR were in men, elderly and Brazilian regions with the lowest Human Development Index (HDI). Greatest number of deaths in men at P1 were from cancers of lung (CMP 19.8%), prostate (14.2%) and pancreas (8.0%). At P2, prostate (18.2%), lung (16.8%) and stomach (7.6%). In women, during P1, breast (20.2%), lung (13.1%) and pancreas (83%), and during P2, the same order, 22.5%, 14.6% and 9.3%, respectively. Cancer accounted for a total of 6,335 PYLL and 40.9% of causes of death were classified as avoidable. Conclusions: Cancer was one of the leading causes of mortality during the study. High pancreatic cancer MR differs from national statistics, requiring more analysis that involves possible occupational exposure. Although preventive actions for healthy life habits, early screening and diagnosis, Brazil presents high cancer mortality rates as showed in this analysis.


2012 ◽  
Vol 36 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Aliza K. Fink ◽  
Robert R. German ◽  
Melonie Heron ◽  
Sherri L. Stewart ◽  
Christopher J. Johnson ◽  
...  

2003 ◽  
Vol 19 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Dominique Laurier ◽  
Margot Tirmarche ◽  
Nicolas Mitton ◽  
Madeleine Valenty ◽  
Patrick Richard ◽  
...  

2006 ◽  
Vol 59 (10) ◽  
pp. 1064-1071 ◽  
Author(s):  
Ralf Bender ◽  
Hajo Zeeb ◽  
Martin Schwarz ◽  
Karl-Heinz Jöckel ◽  
Michael Berger

Sign in / Sign up

Export Citation Format

Share Document