Stimulation of Bone Regeneration by Fragmented Cortical Bone and Porous Calcium Phosphate Ceramics (Tricalcium Phosphate and Hydroxyapatite) — An Experimental Study and Preliminary Clinical Results

1989 ◽  
pp. 619-631
Author(s):  
L. Meiss ◽  
G. Delling
Keyword(s):  
Experimental Study ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Cortical Bone ◽  
Tricalcium Phosphate ◽  
Clinical Results ◽  
Calcium Phosphate Ceramics ◽  
Stimulation Of

scholarly journals Cells responding to surface structure of calcium phosphate ceramics for bone regeneration

2017 ◽  
Vol 11 (11) ◽  
pp. 3273-3283 ◽  
Author(s):  
Jingwei Zhang ◽  
Lanying Sun ◽  
Xiaoman Luo ◽  
Davide Barbieri ◽  
Joost D. de Bruijn ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Surface Structure ◽  
Calcium Phosphate Ceramics

Foamed β-Tricalcium Phosphate Scaffolds

2007 ◽  
Vol 361-363 ◽  
pp. 323-326 ◽  
Author(s):  
Edgar Benjamin Montufar ◽  
C. Gil ◽  
Tania Traykova ◽  
M.P. Ginebra ◽  
Josep A. Planell
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Initial Material ◽  
Sintering Process ◽  
Bioactive Material ◽  
Bioactive Scaffolds ◽  
Calcium Phosphate Cements ◽  
Beta Tricalcium Phosphate ◽  
Nanometric Range

The design and processing of 3D macroporous bioactive scaffolds is one of the milestones for the progress of bone tissue engineering and bone regeneration. Calcium phosphate based ceramics are among the most suitable materials, due to their similarity to the bone mineral. Specifically, beta-tricalcium phosphate (β-TCP) is known to be a resorbable and bioactive material, with well established applications as bone regeneration material. The aim of this work is to explore a new route to obtain β-TCP macroporous scaffolds starting from calcium phosphate cements. To this end foamed calcium phosphate cement, composed of alpha tricalcium phosphate as starting powder was used as initial material. The set foamed structures, made of calcium deficient hydroxyapatite (CDHA) were sintered to obtain the final β-TCP macroporous architecture. The interconnected macroporosity was maintained, whereas the porosity in the nanometric range was strongly reduced by the sintering process. The sintering produced also an increase in the mechanical properties of the scaffold.

Bimodal Porous Bi-Phasic Calcium Phosphate Ceramics and Its Dissolution in SBF Solution

2007 ◽  
Vol 330-332 ◽  
pp. 91-94 ◽  
Author(s):  
Y. Zhang ◽  
Yoshiyuki Yokogawa ◽  
Tetsuya Kameyama
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Reaction Rate ◽  
Ceramic Materials ◽  
Calcium Phosphate Ceramics ◽  
Fine Powders ◽  
Beta Tricalcium Phosphate ◽  
Sbf Solution ◽  
New Phase

Biphasic calcium phosphate (BCP) ceramics, a mixture of hydroxyapatite (HAp) and beta-tricalcium phosphate (β-TCP), of varying HAp/β-TCP ratios were prepared from fine powders. Porous BCP ceramic materials with HAp/β-TCP weight rations of 20/80, 40/60, and 80/20 were prepared. In this study, the bioactivity is reduced at a larger HAp content rate, which is likely related to the high driving pore for the formation of a new phase, and the reaction rate was proportional to the β-TCP. The porous BCP ceramics having a bigger porosity rate can easily under up dissolution. The powder having a larger β-TCP content rate can easily generate a new phase. The dissolution results confirmed that the biodegradation of calcium phosphate ceramics could be controlled by simply adjusting the amount of HAp or β-TCP in the ceramics and porosity rate.

Effect of Macrophage on Degradation of β-TCP Ceramics

2005 ◽  
Vol 288-289 ◽  
pp. 549-552
Author(s):  
Shi Pu Li ◽  
Hong Lian Dai ◽  
Yu Hua Yan ◽  
Xian Ying Cao ◽  
Qi Xin Zheng
Keyword(s):  
Calcium Phosphate ◽  
Carbonic Anhydrase ◽  
Tricalcium Phosphate ◽  
Culture Medium ◽  
Calcium Phosphate Ceramics ◽  
Sem Observation ◽  
Ph Values ◽  
Calcium And Phosphorus

Mice macrophages which were mixed with β-tricalcium phosphate (β-TCP) ceramics powder were cultured, both calcium and phosphorus concentrations in the culture medium were evidently higher than that of β-TCP ceramics powder without cells. The microscope and SEM observation showed that macrophages wrapped β-TCP particles, and then phagocytized them into cytoplasm. The pH values inside and outside macrophage in β-TCP-bearing were tested. The histochemistry observation showed that there were many carbonic anhydrase positive grains in the cytochylema of macroghage after β-TCP ceramics powder being implanted. TEM investigation indicated that many β-TCP particles were phagocytized into the cytochylema of macroghage, and then vacuole was found after particles had degraded. The results showed that macrophages could take part in the degradation of calcium phosphate ceramics in two different ways.

Application of different calcium phosphate ceramics for bone regeneration

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S168 ◽  
Author(s):  
N. Miño-Fariña ◽  
F.M. Muñoz-Guzón ◽  
M. López-Peña ◽  
A. González-Cantalapiedra
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Calcium Phosphate Ceramics

Evaluation of a new tricalcium phosphate for guided bone regeneration: an experimental study in the beagle dog

Odontology ◽  
2018 ◽  
Vol 107 (2) ◽  
pp. 209-218 ◽  
Author(s):  
Mario Pérez-Sayáns ◽  
Alejandro I. Lorenzo-Pouso ◽  
Pablo Galindo-Moreno ◽  
Fernando Muñoz-Guzón ◽  
Antonio González-Cantalapiedra ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Guided Bone Regeneration ◽  
Beagle Dog

Fabrication of Biphasic Calcium Phosphate Bioceramics from the Recycling of Bone Ash

2012 ◽  
Vol 610-613 ◽  
pp. 2328-2331 ◽  
Author(s):  
Nan Hee Lee ◽  
Kyu Hong Hwang ◽  
Jong Kook Lee
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Raw Materials ◽  
Liquid Environment ◽  
Bone China ◽  
Calcium Phosphate Ceramics ◽  
Bone Ash ◽  
Naoh Solution ◽  
Moisture Protection

Biphasic calcium phosphate bioceramics were fabricated from the recycling of bone ash which is mostly used as raw materials of bone china. Precursor calcium phosphate powders were prepared by soaking the commercial bone ash in 0.1 M of NaOH solution at 80°C for 4 h. Calcium phosphate powders was obtained by calcination at 800°C for 1 h to completely remove residual organics. Biphasic calcium phosphate bioceramics which is composed of hydroxyapatite and tricalcium phosphate was fabricated by the sintering of pressed compacts at 1200°C for 1 h under moisture protection. The bone ash derived-biphasic calcium phosphate ceramics consists of mostly HA and small amounts of α-tricalcium phosphate, magnesium oxide and calcium oxide. After polishing the HA ceramics, they were immersed in buffered water at 37°C for 3 and 7 days. The bone ash derived- biphasic calcium phosphate ceramics show high biostability in liquid environment with immersion time compared with commercial calcium phosphate ceramics.

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