Foamed β-Tricalcium Phosphate Scaffolds

2007 ◽  
Vol 361-363 ◽  
pp. 323-326 ◽  
Author(s):  
Edgar Benjamin Montufar ◽  
C. Gil ◽  
Tania Traykova ◽  
M.P. Ginebra ◽  
Josep A. Planell
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Initial Material ◽  
Sintering Process ◽  
Bioactive Material ◽  
Bioactive Scaffolds ◽  
Calcium Phosphate Cements ◽  
Beta Tricalcium Phosphate ◽  
Nanometric Range

The design and processing of 3D macroporous bioactive scaffolds is one of the milestones for the progress of bone tissue engineering and bone regeneration. Calcium phosphate based ceramics are among the most suitable materials, due to their similarity to the bone mineral. Specifically, beta-tricalcium phosphate (β-TCP) is known to be a resorbable and bioactive material, with well established applications as bone regeneration material. The aim of this work is to explore a new route to obtain β-TCP macroporous scaffolds starting from calcium phosphate cements. To this end foamed calcium phosphate cement, composed of alpha tricalcium phosphate as starting powder was used as initial material. The set foamed structures, made of calcium deficient hydroxyapatite (CDHA) were sintered to obtain the final β-TCP macroporous architecture. The interconnected macroporosity was maintained, whereas the porosity in the nanometric range was strongly reduced by the sintering process. The sintering produced also an increase in the mechanical properties of the scaffold.

Synthesis of Alpha-Tricalcium Phosphate by Wet Reaction and Evaluation of Mechanical Properties

2012 ◽  
Vol 727-728 ◽  
pp. 1164-1169 ◽  
Author(s):  
Mônica Beatriz Thürmer ◽  
Rafaela Silveira Vieira ◽  
Juliana Machado Fernandes ◽  
Wilbur Trajano Guerin Coelho ◽  
Luis Alberto Santos
Keyword(s):  
Mechanical Properties ◽  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Calcium Nitrate ◽  
Chemical Precipitation ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
X Ray Diffraction ◽  
X Ray ◽  
Calcium Phosphate Cements

Calcium phosphate cements have bioactivity and osteoconductivity and can be molded and replace portions of bone tissue. The aim of this work was to study the obtainment of α-tricalcium phosphate, the main phase of calcium phosphate cement, by wet reaction from calcium nitrate and phosphoric acid. There are no reports about α-tricalcium phosphate obtained by this method. Two routes of chemical precipitation were evaluated and the use of two calcinations temperatures to obtain the phase of cement. The influence of calcination temperature on the mechanical properties of cement was evaluated. Cement samples were characterized by particle size analysis, X-ray diffraction, mechanical strength and scanning electron microscopy. The results demonstrate the strong influence of synthesis route on the crystalline phases of cement and the influence of concentration of reactants on the product of the reaction, as well as, on the mechanical properties of cement.

Processing and in vivo evaluation of multiphasic calcium phosphate cements with dual tricalcium phosphate phases

2012 ◽  
Vol 8 (9) ◽  
pp. 3500-3508 ◽  
Author(s):  
Marco A. Lopez-Heredia ◽  
Matilde Bongio ◽  
Marc Bohner ◽  
Vincent Cuijpers ◽  
Louis A.J.A. Winnubst ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Cements

Melatonin decorated 3D-printed beta-tricalcium phosphate scaffolds promoting bone regeneration in a rat calvarial defect model

2019 ◽  
Vol 7 (20) ◽  
pp. 3250-3259 ◽  
Author(s):  
Yali Miao ◽  
Yunhua Chen ◽  
Xiao Liu ◽  
Jingjing Diao ◽  
Naru Zhao ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
3D Printed ◽  
Rat Calvarial Defect

3D-printed β-TCP scaffolds decorated with melatonin via dopamine mussel-inspired chemistry enhance the osteogenesis and in vivo bone regeneration.

scholarly journals Production and Characterization of a 316L Stainless Steel/β-TCP Biocomposite Using the Functionally Graded Materials (FGMs) Technique for Dental and Orthopedic Applications

Metals ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1923
Author(s):  
Bruna Horta Bastos Kuffner ◽  
Patricia Capellato ◽  
Larissa Mayra Silva Ribeiro ◽  
Daniela Sachs ◽  
Gilbert Silva
Keyword(s):  
Mechanical Properties ◽  
Stainless Steel ◽  
Calcium Phosphate ◽  
Functionally Graded Materials ◽  
Tricalcium Phosphate ◽  
316L Stainless Steel ◽  
Functionally Graded ◽  
Graded Materials ◽  
Beta Tricalcium Phosphate ◽  
Orthopedic Applications

Metallic biomaterials are widely used for implants and dental and orthopedic applications due to their good mechanical properties. Among all these materials, 316L stainless steel has gained special attention, because of its good characteristics as an implantable biomaterial. However, the Young’s modulus of this metal is much higher than that of human bone (~193 GPa compared to 5–30 GPa). Thus, a stress shielding effect can occur, leading the implant to fail. In addition, due to this difference, the bond between implant and surrounding tissue is weak. Already, calcium phosphate ceramics, such as beta-tricalcium phosphate, have shown excellent osteoconductive and osteoinductive properties. However, they present low mechanical strength. For this reason, this study aimed to combine 316L stainless steel with the beta-tricalcium phosphate ceramic (β-TCP), with the objective of improving the steel’s biological performance and the ceramic’s mechanical strength. The 316L stainless steel/β-TCP biocomposites were produced using powder metallurgy and functionally graded materials (FGMs) techniques. Initially, β-TCP was obtained by solid-state reaction using powders of calcium carbonate and calcium phosphate. The forerunner materials were analyzed microstructurally. Pure 316L stainless steel and β-TCP were individually submitted to temperature tests (1000 and 1100 °C) to determine the best condition. Blended compositions used to obtain the FGMs were defined as 20% to 20%. They were homogenized in a high-energy ball mill, uniaxially pressed, sintered and analyzed microstructurally and mechanically. The results indicated that 1100 °C/2 h was the best sintering condition, for both 316L stainless steel and β-TCP. For all individual compositions and the FGM composite, the parameters used for pressing and sintering were appropriate to produce samples with good microstructural and mechanical properties. Wettability and hemocompatibility were also achieved efficiently, with no presence of contaminants. All results indicated that the production of 316L stainless steel/β-TCP FGMs through PM is viable for dental and orthopedic purposes.

scholarly journals Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres

2020 ◽  
Vol 21 (11) ◽  
pp. 3745
Author(s):  
Michiyo Honda ◽  
Yusuke Kawanobe ◽  
Kohei Nagata ◽  
Ken Ishii ◽  
Morio Matsumoto ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Bacterial Adhesion ◽  
Inflammatory Responses ◽  
Spray Pyrolysis Technique ◽  
Biological Properties ◽  
Histological Evaluation ◽  
Bone Apposition ◽  
Calcium Phosphate Cements

Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate cements (CPCs) with bactericidal properties is indispensable. The aim of this study was to fabricate antibacterial CPCs and evaluate their biological properties. Silver-containing tricalcium phosphate (Ag-TCP) microspheres consisting of α/β-TCP phases were synthesized by an ultrasonic spray-pyrolysis technique. The powders prepared were mixed with the setting liquid to fabricate the CPCs. The resulting cements consisting of β-TCP and hydroxyapatite had a porous structure and wash-out resistance. Additionally, silver and calcium ions could be released into the culture medium from Ag-TCP cements for a long time accompanied by the dissolution of TCP. These data showed the bioresorbability of the Ag-TCP cement. In vitro antibacterial evaluation demonstrated that both released and immobilized silver suppressed the growth of bacteria and prevented bacterial adhesion to the surface of CPCs. Furthermore, histological evaluation by implantation of Ag-TCP cements into rabbit tibiae exhibited abundant bone apposition on the cement without inflammatory responses. These results showed that Ag-TCP cement has a good antibacterial property and good biocompatibility. The present Ag-TCP cements are promising for bone tissue engineering and may be used as antibacterial biomaterials.

Effects of porous beta-tricalcium phosphate-based ceramics used as an E. coli-derived rhBMP-2 carrier for bone regeneration

2013 ◽  
Vol 24 (9) ◽  
pp. 2117-2127 ◽  
Author(s):  
Jae Hyup Lee ◽  
Mi Young Ryu ◽  
Hae-Ri Baek ◽  
Kyung Mee Lee ◽  
Jun-Hyuk Seo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
E Coli ◽  
Beta Tricalcium Phosphate

scholarly journals Histological Evaluation of a New Beta-Tricalcium Phosphate/Hydroxyapatite/Poly (1-Lactide-Co-Caprolactone) Composite Biomaterial in the Inflammatory Process and Repair of Critical Bone Defects

Symmetry ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1356
Author(s):  
Elizabeth Ferreira Martinez ◽  
Ana Elisa Amaro Rodrigues ◽  
Lucas Novaes Teixeira ◽  
Andrea Rodrigues Esposito ◽  
Walter Israel Rojas Cabrera ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Bone Repair ◽  
Inflammatory Process ◽  
Histological Evaluation ◽  
Alloplastic Material ◽  
Beta Tricalcium Phosphate ◽  
Evaluation Time ◽  
Synthetic Biomaterial ◽  
Critical Bone Defects

Background: The use of biomaterials is commonplace in dentistry for bone regeneration. The aim of this study was to evaluate the performance of a new alloplastic material for bone repair in critical defects and to evaluate the extent of the inflammatory process. Methods: Forty-five New Zealand rabbits were divided into five groups according to evaluation time (7, 14, 30, 60, 120 days), totaling 180 sites with six-millimeter diameter defects in their tibiae. The defects were filled with alloplastic material consisting of poly (lactide-co-caprolactone), beta-tricalcium phosphate, hydroxyapatite and nano-hydroxyapatite (BTPHP) in three different presentations: paste, block, and membrane. Comparisons were established with reference materials, such as Bio-ossTM, Bio-oss CollagenTM, and Bio-gideTM, respectively. The samples were HE-stained and evaluated for inflammatory infiltrate (scored for intensity from 0 to 3) and the presence of newly formed bone at the periphery of the defects. Results: Greater bone formation was observed for the alloplastic material and equivalent inflammatory intensity for both materials, regardless of evaluation time. At 30 days, part of the synthetic biomaterial, regardless of the presentation, was resorbed. Conclusions: We concluded that this novel alloplastic material showed osteoconductive potential, biocompatibility, low inflammatory response, and gradual resorption, thus an alternative strategy for guided bone regeneration.

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