The Lyt-2 Accessory Molecule is Responsible for the Weak Mouse Anti-HLA Xeno-Response

1990 ◽  
pp. 165-172 ◽  
Author(s):  
G. J. Hämmerling ◽  
U. Kalinke ◽  
B. Arnold
Keyword(s):  
Accessory Molecule

scholarly journals The mouse vitronectin receptor is a T cell activation antigen.

1991 ◽  
Vol 173 (2) ◽  
pp. 343-347 ◽  
Author(s):  
K Moulder ◽  
K Roberts ◽  
E M Shevach ◽  
J E Coligan
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Lymphoid Cells ◽  
Vitronectin Receptor ◽  
Cell Functions ◽  
Murine Homologue ◽  
Accessory Molecule ◽  
T Cell Lines ◽  
Activation Antigen

In this report, we demonstrate that the T cell activation antigen, recognized by monoclonal antibody H9.2B8, is the murine homologue of the vitronectin receptor (VNR) and, thereby, we provide initial evidence that VNR is expressed on lymphoid cells. VNR is expressed on a variety of T cell lines, tumors, and Con A-activated splenocytes, but not resting T cells, and is capable of binding to the extracellular matrix proteins fibronectin, fibrinogen, and vitronectin, via the tripeptide sequence RGD. There was no evidence of novel beta chains pairing with the VNR alpha chain, as has been demonstrated in some human cells. In view of recent studies demonstrating that this molecule functions as an accessory molecule in T cell activation, the VNR may play an important role in mouse T cell functions.

Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28

Science ◽  
1991 ◽  
Vol 251 (4991) ◽  
pp. 313-316 ◽  
Author(s):  
J. Fraser ◽  
B. Irving ◽  
G. Crabtree ◽  
A Weiss
Keyword(s):  
T Cell ◽  
Interleukin 2 ◽  
Enhancer Activity ◽  
Gene Enhancer ◽  
Accessory Molecule

Accessory Molecule Expression in Human Thymomas and Thymus

1997 ◽  
pp. 229-234 ◽  
Author(s):  
S. Appiah-Boadu ◽  
J. A. Aarli ◽  
G. O. Skeie ◽  
N. E. Gilhus
Keyword(s):  
Accessory Molecule

Development of the T Cell Repertoire: Contributions of Both TCR-MHC and Accessory Molecule-MHC Interactions

1989 ◽  
pp. 289-296 ◽  
Author(s):  
L. A. Jones ◽  
J. C. Zúñiga-Pflücker ◽  
J. S. Fine ◽  
D. L. Longo ◽  
A. M. Kruisbeek
Keyword(s):  
T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Accessory Molecule

CD48 May serve as an accessory molecule for the activation of a subset of human γ/δ T cells

1996 ◽  
Vol 46 (2) ◽  
pp. 82-92 ◽  
Author(s):  
Caroline Flament ◽  
Kamel Bellagha ◽  
Alexandra Rosenthal-Allieri ◽  
Salem Chouaib ◽  
Fathia Mami-Chouaib
Keyword(s):  
T Cells ◽  
Accessory Molecule

scholarly journals Mutation in Fas Ligand Impairs Maturation of Thymocytes Bearing Moderate Affinity T Cell Receptors

2003 ◽  
Vol 198 (2) ◽  
pp. 349-360 ◽  
Author(s):  
Tamar E. Boursalian ◽  
Pamela J. Fink
Keyword(s):  
T Cell ◽  
Positive Selection ◽  
T Cell Activation ◽  
T Cell Receptors ◽  
Cell Activation ◽  
Fas Ligand ◽  
Costimulatory Molecule ◽  
Thymocyte Development ◽  
Cell Receptors ◽  
Accessory Molecule

Fas ligand, best known as a death-inducer, is also a costimulatory molecule required for maximal proliferation of mature antigen-specific CD4+ and CD8+ T cells. We now extend the role of Fas ligand by showing that it can also influence thymocyte development. T cell maturation in some, but not all, strains of TCR transgenic mice is severely impaired in thymocytes expressing mutant Fas ligand incapable of interacting with Fas. Mutant Fas ligand inhibits neither negative selection nor death by neglect. Instead, it appears to modulate positive selection of thymocytes expressing both class I– and class II–restricted T cell receptors of moderate affinity for their positively selecting ligands. Fas ligand is therefore an inducer of death, a costimulator of peripheral T cell activation, and an accessory molecule in positive selection.

scholarly journals The nephron (pro)renin receptor: function and significance

2016 ◽  
Vol 311 (6) ◽  
pp. F1145-F1148 ◽  
Author(s):  
Nirupama Ramkumar ◽  
Donald E. Kohan
Keyword(s):  
Renin Angiotensin System ◽  
Ang Ii ◽  
Distal Nephron ◽  
Angiotensin System ◽  
New Developments ◽  
Multifunctional Protein ◽  
Physiological Relevance ◽  
Accessory Molecule ◽  
Early Lethality ◽  
Cell Signaling Pathways

The (pro)renin receptor (PRR) is a multifunctional protein that is part of the renin-angiotensin system and is an important accessory molecule for the vacuolar H+-ATPase. The PRR is widely expressed in the kidney with relatively high abundance in the distal nephron. Determining the physiological relevance of the PRR has been challenging due to early lethality in whole animal and cell-specific PRR knockout models. Recently, viable renal cell-specific PRR knockout mice have been developed; these studies suggest that PRR in the nephron can modulate renal function via angiotensin II (ANG II)-dependent and -independent cell signaling pathways. In this mini-review, we highlight new developments in nephron PRR function in health and in pathophysiological conditions.

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