Clinical Relevance of Gene Expression in Cerebral Ischemia

1994 ◽  
pp. 325-328
Author(s):  
F. M. Yatsu
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Clinical Relevance

scholarly journals Expression of NMDA receptor and microRNA-219 in rats submitted to cerebral ischemia associated with alcoholism

2017 ◽  
Vol 75 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Cristiane Iozzi Silva ◽  
Paulo Cézar Novais ◽  
Andressa Romualdo Rodrigues ◽  
Camila A.M. Carvalho ◽  
Benedicto Oscar Colli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Brain Tissue ◽  
Wistar Rats ◽  
Molecular Mechanisms ◽  
Inverse Correlation ◽  
Control Group ◽  
The Brain ◽  
Lower Expression ◽  
Control Sham

ABSTRACT Alcohol consumption aggravates injuries caused by ischemia. Many molecular mechanisms are involved in the pathophysiology of cerebral ischemia, including neurotransmitter expression, which is regulated by microRNAs. Objective: To evaluate the microRNA-219 and NMDA expression in brain tissue and blood of animals subjected to cerebral ischemia associated with alcoholism. Methods: Fifty Wistar rats were divided into groups: control, sham, ischemic, alcoholic, and ischemic plus alcoholic. The expression of microRNA-219 and NMDA were analyzed by real-time PCR. Results: When compared to the control group, the microRNA-219 in brain tissue was less expressed in the ischemic, alcoholic, and ischemic plus alcoholic groups. In the blood, this microRNA had lower expression in alcoholic and ischemic plus alcoholic groups. In the brain tissue the NMDA gene expression was greater in the ischemic, alcoholic, and ischemic plus alcoholic groups. Conclusion: A possible modulation of NMDA by microRNA-219 was observed with an inverse correlation between them.

scholarly journals Changes in Gene Expression in the Rat Hippocampus after Focal Cerebral Ischemia

2011 ◽  
Vol 50 (3) ◽  
pp. 173 ◽  
Author(s):  
Jun Young Chung ◽  
Jae Woo Yi ◽  
Sung Min Kim ◽  
Young Jin Lim ◽  
Joo Ho Chung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Rat Hippocampus

scholarly journals Limited clinical relevance of mitochondrial DNA mutation and gene expression analyses in ovarian cancer

BMC Cancer ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Piotr Bragoszewski ◽  
Jolanta Kupryjanczyk ◽  
Ewa Bartnik ◽  
Andrea Rachinger ◽  
Jerzy Ostrowski
Keyword(s):  
Gene Expression ◽  
Ovarian Cancer ◽  
Mitochondrial Dna ◽  
Clinical Relevance ◽  
Mitochondrial Dna Mutation ◽  
Dna Mutation ◽  
Gene Expression Analyses

scholarly journals Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice

2018 ◽  
Vol 9 (2) ◽  
pp. 249 ◽  
Author(s):  
Chengjie Zhang ◽  
Yanbing Zhu ◽  
Song Wang ◽  
Zheng Zachory Wei ◽  
Michael Qize Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Temporal Gene Expression

Gene Expression in Cerebral Ischemia: A New Approach for Neuroprotection

2006 ◽  
Vol 21 (2) ◽  
pp. 30-37 ◽  
Author(s):  
Mónica Millán ◽  
Juan Arenillas
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
New Approach
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