Environmental Influence on Gene Expression and Recovery from Cerebral Ischemia

1999 ◽  
pp. 51-55 ◽  
Author(s):  
Barbro B. Johansson ◽  
L. Zhao ◽  
B. Mattsson
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Environmental Influence

scholarly journals Expression of NMDA receptor and microRNA-219 in rats submitted to cerebral ischemia associated with alcoholism

2017 ◽  
Vol 75 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Cristiane Iozzi Silva ◽  
Paulo Cézar Novais ◽  
Andressa Romualdo Rodrigues ◽  
Camila A.M. Carvalho ◽  
Benedicto Oscar Colli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Brain Tissue ◽  
Wistar Rats ◽  
Molecular Mechanisms ◽  
Inverse Correlation ◽  
Control Group ◽  
The Brain ◽  
Lower Expression ◽  
Control Sham

ABSTRACT Alcohol consumption aggravates injuries caused by ischemia. Many molecular mechanisms are involved in the pathophysiology of cerebral ischemia, including neurotransmitter expression, which is regulated by microRNAs. Objective: To evaluate the microRNA-219 and NMDA expression in brain tissue and blood of animals subjected to cerebral ischemia associated with alcoholism. Methods: Fifty Wistar rats were divided into groups: control, sham, ischemic, alcoholic, and ischemic plus alcoholic. The expression of microRNA-219 and NMDA were analyzed by real-time PCR. Results: When compared to the control group, the microRNA-219 in brain tissue was less expressed in the ischemic, alcoholic, and ischemic plus alcoholic groups. In the blood, this microRNA had lower expression in alcoholic and ischemic plus alcoholic groups. In the brain tissue the NMDA gene expression was greater in the ischemic, alcoholic, and ischemic plus alcoholic groups. Conclusion: A possible modulation of NMDA by microRNA-219 was observed with an inverse correlation between them.

scholarly journals Changes in Gene Expression in the Rat Hippocampus after Focal Cerebral Ischemia

2011 ◽  
Vol 50 (3) ◽  
pp. 173 ◽  
Author(s):  
Jun Young Chung ◽  
Jae Woo Yi ◽  
Sung Min Kim ◽  
Young Jin Lim ◽  
Joo Ho Chung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Rat Hippocampus

Gene expression at the pink-eyed dilution (p) locus in the mouse is confirmed to be pigment cell autonomous using recombinant embryonic skin grafts

Development ◽  
1985 ◽  
Vol 87 (1) ◽  
pp. 65-73
Author(s):  
Dennis A. Stephenson ◽  
Janet E. Hornby
Keyword(s):  
Gene Expression ◽  
Environmental Influence ◽  
Pigment Cell ◽  
Epistatic Effect ◽  
Skin Grafts ◽  
Experimental Systems ◽  
Grafting Technique ◽  
Embryonic Skin ◽  
Pink Eyed Dilution ◽  
P Locus

Sash (Wsh), a viable and fully fertile allele of the dominant spotting (W) locus (Lyon & Glenister, 1982) has been expression at the pink-eyed dilution (p) locus. Reciprocal recombinant epidermal//dermal skin grafts were constructed from 13-day embryonic skin of p and Wsh homozygotes. Thus in the reciprocal experiments pink-eyed dilution melanocytes were exposed to any environmental influence from the wild-type allele of thep locus in either the epidermis (when WshWsh) or the dermis (when WshWsh). The hair pigmentation of the grafts recovered after three weeks beneath the testicular tunica of adult male mice was always typical of the p phenotype showing thatp is melanocyte autonomous. This result was supported by experiments using a modification of Mayer's (1965) neural crest grafting technique and the construction of 14-day recombinant skin grafts. Sash (WshWsh) epidermis can support melanocyte differentiation and pigment production but lacks functional melanocytes. The advantages of Wsh in experimental systems for testing the site of pigment gene expression have been demonstrated. Control experiments confirmed the dermal influence of agouti (A) over non-agouti (a) epidermis but non-agouti dermis did not overrule agouti pink-eyed dilution (AA pp) epidermis suggesting an epistatic effect ofp in the melanocyte.

scholarly journals Temporal Gene Expression Profiles after Focal Cerebral Ischemia in Mice

2018 ◽  
Vol 9 (2) ◽  
pp. 249 ◽  
Author(s):  
Chengjie Zhang ◽  
Yanbing Zhu ◽  
Song Wang ◽  
Zheng Zachory Wei ◽  
Michael Qize Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Temporal Gene Expression

Gene Expression in Cerebral Ischemia: A New Approach for Neuroprotection

2006 ◽  
Vol 21 (2) ◽  
pp. 30-37 ◽  
Author(s):  
Mónica Millán ◽  
Juan Arenillas
Keyword(s):  
Gene Expression ◽  
Cerebral Ischemia ◽  
New Approach
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