Characterization of an R Factor to Fosfomycin

Plasmids ◽  
1977 ◽  
pp. 473-476
Author(s):  
E. J. Perea ◽  
R. M. Daza ◽  
Victoria Borobio ◽  
I. Andres ◽  
J. M. Ortiz
Keyword(s):  
1971 ◽  
Vol 123 (4) ◽  
pp. 501-505 ◽  
Author(s):  
J. W. Dale

1. The amino acid composition of the β-lactamase from E. coli (R-1818) was determined. 2. The R-1818 β-lactamase is inhibited by formaldehyde, hydroxylamine, sodium azide, iodoacetamide, iodine and sodium chloride. 3. The Km values for benzylpenicillin, ampicillin and oxacillin have been determined by using the R-factor enzyme from different host species. The same values were obtained, irrespective of the host bacterium. 4. The molecular weight of the enzyme was found to be 44600, and was the same for all host species. 5. The relationship of R-1818 and R-GN238 β-lactamases is discussed.


1972 ◽  
Vol 25 (8) ◽  
pp. 483-484 ◽  
Author(s):  
SHINICHI KONDO ◽  
HARUO YAMAMOTO ◽  
HIROSHI NAGANAWA ◽  
HAMAO UMEZAWA ◽  
SUSUMU MITSUHASHI

1974 ◽  
Vol 24 (3) ◽  
pp. 333-343 ◽  
Author(s):  
T. J. Foster ◽  
Áine Walsh

SUMMARYThe tetracycline-resistance determinants of R-factors from different compatibility groups have been tested inEscherichia coliK12 and phenotypically classified into two major classes. Class I determinants confer high-level resistance to tetracycline (> 100 μg/ml) and moderate resistance to minocycline (5–25 μg/ml) while those of Class II gave moderate resistance to tetracycline (50–70 μg/ml) and low resistance to minocycline. Each class was subdivided because of variation in resistance profiles and in the abilities of tetracycline and minocycline to induce increased resistance. Strains carrying two compatible TetrR-factors of the same or different phenotypic groups did not show increased tetracycline resistance.


2010 ◽  
Vol 7 (3) ◽  
pp. 887-893
Author(s):  
M. L. Mrad ◽  
C. Ben Nasr ◽  
M. Rzaigui

Chemical preparation and x-ray characterization of a new compound hexaaqua-1,3-diammoniumpropane cobalt(II) nitrate, Co(H2O)6[C3H12N2] (NO3)4are reported. This mixed organo-mineral compound crystallizes in the orthorhombic system with Cmcm space group. The unit cell dimensions are: a = 10.795(7), b = 11.969(4), c = 14.685(5) Å, Z = 4 and V = 1897.5(12) Å3. The structure was solved using the direct method and refined to reliability R-factor of 0.036 using 2554 independent reflections. In this atomic arrangement the different species built a three-dimensional network.


1982 ◽  
Vol 35 (12) ◽  
pp. 2399 ◽  
Author(s):  
GH Searle ◽  
TW Hambley

The reaction [Co(dpt)Cl3]+ dien in propan-2-ol [dpt=di(3-aminopropyl)amine, dien = diethylene-triamine] gives mer-[Co(dpt)2]3+ and the three geometric isomers of [Co(dien)2]3+, almost quantitatively. The reaction [Co(dien)Cl3] + dpt in propan-2-ol, catalysed by water, yields the three isomers of [Co(dien)(dpt)]3+ as the main products, in the approximate ratio u-fac : mer : s-fac 4 : 2 : 1. Preparation of mixed amine complexes by substitution therefore requires that the amine (dien) forming the more stable complexes be incorporated in the reactant complex. The geometric structures of the isolated [Co(dien)(dpt)] (ClO4)3 isomers are assigned by 13C n.m.r. spectra. They each hydrolyse in water or base, the mer isomer rapidly, and no isomerization has been detected. X-ray crystallographic analysis of mer-[Co(dien)(dpt)]2 (S2O6)3,H2O,EtOH (from the isolated perchlorate by metathesis) confirms the assigned mer geometry. The two independent complex molecules in the asymmetric unit have different conformational geometries. The crystals are monoclinic, space group P21/c, with a 15.548(4), b 9.178(3), c 31.664(8) �,β 89,04(2)�. The structure was refined by blocked-matrix least-squares techniques to an R-factor (on 2752 F) of 0.058.


1973 ◽  
Vol 3 (1) ◽  
pp. 68-73 ◽  
Author(s):  
F. A. Rubin ◽  
D. H. Smith
Keyword(s):  

2012 ◽  
Vol 9 (2) ◽  
pp. 525-531
Author(s):  
Mohamed Ziaulla ◽  
Afshan Banu ◽  
Shridhar I. Panchamukhi ◽  
Imtiyaz Ahmed M. Khazi ◽  
Noor Shahina Begum

X-ray characterization of 7-methyl-5,6,7,8-tetrahydro[1]benzothieno [2,3-d]pyrimidin-4[3H]one is described. The compound crystallizes in the monoclinic space group P21/c with a=7.0013(2)Å, b=8.3116(3)Å, c=18.374(6)Å, β=91.746(2)°, V=1068.76(6)Å3, z=4. The structure was solved using the direct method and refined to reliability R-factor of 0.0639 using 3180 independent reflections The crystal structure is further stabilized by intermolecular C-H...N, N-H...N C-H...O, N-H...O, and π-π interactions.


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