Listeria monocytogenes: a Model System to Study Invasion and Spread of Bacteria in the Central Nervous System

2002 ◽  
pp. 213-226 ◽  
Author(s):  
E. Domann ◽  
M. Deckert ◽  
D. Schlüter ◽  
T. Chakraborty
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Listeria Monocytogenes ◽  
Model System ◽  
The Central Nervous System

scholarly journals 11beta-hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons

2002 ◽  
Vol 29 (3) ◽  
pp. 319-325 ◽  
Author(s):  
SM MacKenzie ◽  
M Lai ◽  
CJ Clark ◽  
R Fraser ◽  
CE Gomez-Sanchez ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hippocampal Neurons ◽  
Primary Cultures ◽  
Local System ◽  
Model System ◽  
Biochemical Reactions ◽  
Aldosterone Synthase ◽  
Fetal Rat ◽  
The Central Nervous System

The central nervous system produces many of the enzymes responsible for corticosteroid synthesis. A model system to study the regulation of this local system would be valuable. Previously, we have shown that primary cultures of hippocampal neurons isolated from the fetal rat can perform the biochemical reactions associated with the enzymes 11beta-hydroxylase and aldosterone synthase. Here, we demonstrate directly that these enzymes are present within primary cultures of fetal rat hippocampal neurons.

scholarly journals Evidence for Intraaxonal Spread of Listeria Monocytogenes from the Periphery to the Central Nervous System

2001 ◽  
Vol 11 (4) ◽  
pp. 432-438 ◽  
Author(s):  
Ellen-Ann Antal ◽  
Else Marit Løberg ◽  
Paula Bracht ◽  
Kjetil K. Melby ◽  
Jan Maehlen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Listeria Monocytogenes ◽  
The Central Nervous System

Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system

2004 ◽  
Vol 7 (2) ◽  
pp. 167-180 ◽  
Author(s):  
Olivier F. Join-Lambert ◽  
Sophie Ezine ◽  
Alban Le Monnier ◽  
Francis Jaubert ◽  
Masaru Okabe ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Nervous System ◽  
Listeria Monocytogenes ◽  
Myeloid Cells ◽  
Bacterial Invasion ◽  
The Central Nervous System

Cerebral Abscess Caused by Listeria monocytogenes: Case Report and Literature Review

2021 ◽  
Author(s):  
Debora Cipriani ◽  
Michael Trippel ◽  
Klaus-Jürgen Buttler ◽  
Eva Rohr ◽  
Dirk Wagner ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Listeria Monocytogenes ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Stereotactic Aspiration ◽  
Invasive Diseases ◽  
Immunosuppressed Patients ◽  
The Central Nervous System ◽  
Brain Abscesses

Abstract Background Listeria monocytogenes is an opportunistic gram-positive, facultative intracellular bacterium that causes invasive diseases mostly in pregnant women and immunosuppressed patients. Despite the predilection toward the central nervous system (CNS), it usually causes meningitis and meningoencephalitis, whereas brain abscesses are very uncommon. Case presentation We describe the case of a 69-year-old homeless patient with a brain abscess due to L. monocytogenes who was successfully treated surgically by a guided stereotactic aspiration and antibiotic therapy with ampicillin and gentamicin. Our patient was discharged after 4 weeks of therapy without neurologic deficits. Additionally, we provide a review of the literature of brain abscesses caused by L. monocytogenes. Conclusions This case highlights the need to drain cerebral abscesses and culture pus to correctly treat patients with antibiotics, especially given the high mortality rate of this infectious entity.

Relative susceptibility of elements of the cerebral cortex to mechanical trauma in the rat

1971 ◽  
Vol 35 (5) ◽  
pp. 517-522 ◽  
Author(s):  
Melvin H. Epstein
Keyword(s):  
Central Nervous System ◽  
Tissue Culture ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Nutrient Medium ◽  
Model System ◽  
Mechanical Trauma ◽  
Content Type ◽  
The Central Nervous System ◽  
Fine Print

✓ A model system for the study of trauma to elements of the central nervous system is described. It consists of floating samples of cortex (1 mm3) in nutrient medium. After variable amounts of trauma the cortical samples are allowed to grow in tissue culture, or their individual cytoarchitectonic layers are studied metabolically in the Cartesian diver. The results indicate that neurons are the most labile cellular elements when the cerebral cortex is exposed to mechanical trauma. The glia are the next most vulnerable to damage while the fibroblastic series are highly resistant to concussive forces.

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