scholarly journals Lung Cancer and Lung Injury: The Dual Role of Ceramide

2013 ◽  
pp. 93-113 ◽  
Author(s):  
Tzipora Goldkorn ◽  
Samuel Chung ◽  
Simone Filosto
Keyword(s):  
Lung Cancer ◽  
Lung Injury ◽  
Dual Role

Abstract 2274: The dual role of fibronectin in lung cancer progression

2015 ◽  
Author(s):  
Hung-Chi Cheng ◽  
Ming-Min Chang ◽  
Yau-Lin Tseng
Keyword(s):  
Lung Cancer ◽  
Cancer Progression ◽  
Dual Role

scholarly journals P1.07-028 Dual Role of the Focal Adhesion Kinase in Small-Cell Lung Cancer

2017 ◽  
Vol 12 (1) ◽  
pp. S713
Author(s):  
Frank Aboubakar Nana ◽  
Marylène Lecocq ◽  
Maha Ladjemi ◽  
Bruno Detry ◽  
Sebastien Dupasquier ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Dual Role ◽  
Small Cell Lung

scholarly journals P1.02-019 Dual Role of Notch in Lung Cancer

2017 ◽  
Vol 12 (11) ◽  
pp. S1931
Author(s):  
S. Sinicropi-Yao ◽  
J. Amann ◽  
K. Coombes ◽  
D. Carbone
Keyword(s):  
Lung Cancer ◽  
Dual Role

Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury

2002 ◽  
Vol 33 (4) ◽  
pp. 491-501 ◽  
Author(s):  
Martina Dörger ◽  
Anne-Marie Allmeling ◽  
Rainer Kiefmann ◽  
Alke Schropp ◽  
Fritz Krombach
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Lung Injury ◽  
Inducible Nitric Oxide Synthase ◽  
Dual Role ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Pivotal role of the HMGB1/sRAGE axis in drug-induced lung injury in advanced lung cancer with pre-existing interstitial lung disease

2020 ◽  
Author(s):  
Satoshi Nakao ◽  
Yamaguchi Kakuhiro ◽  
Shinjiro Sakamoto ◽  
Yasushi Horimasu ◽  
Takeshi Masuda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Injury ◽  
Lung Disease ◽  
Pivotal Role ◽  
Advanced Lung Cancer ◽  
Drug Induced

scholarly journals Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation

2020 ◽  
Vol 11 ◽  
Author(s):  
Chengliang Yang ◽  
Shaf Keshavjee ◽  
Mingyao Liu
Keyword(s):  
Clinical Trials ◽  
Lung Injury ◽  
Dual Role ◽  
Host Cells ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Alpha 1 Antitrypsin ◽  
Transmembrane Serine Protease ◽  
Anti Inflammation

Many drugs have been approved for clinical trials for the treatment of COVID-19 disease, focusing on either antiviral or anti-inflammatory approaches. Combining antiviral and anti-inflammatory drugs or therapies together may be more effective. Human alpha-1 antitrypsin (A1AT) is a blood circulating glycoprotein that is best known as a protease inhibitor. It has been used to treat emphysema patients with A1AT deficiency for decades. We and others have demonstrated its role in reducing acute lung injury by inhibiting inflammation, cell death, coagulation, and neutrophil elastase activation. Recently, A1AT has been found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by inhibiting transmembrane serine protease 2 (TMPRSS2), a protease involved in the entry of SARS-CoV-2 into host cells. This dual role of both antiviral infection and anti-inflammation makes A1AT a unique and excellent candidate for COVID-19 treatment. Three clinical trials of A1AT for COVID-19 treatment have recently been approved in several countries. It is important to determine whether A1AT can prevent the progress from moderate to severe lung injury and eventually to be used to treat COVID-19 patients with acute respiratory distress syndrome.

scholarly journals Friend or foe? The dual role of neutrophils in lung injury and repair

Thorax ◽  
2018 ◽  
Vol 73 (4) ◽  
pp. 305-307 ◽  
Author(s):  
Frances S Grudzinska ◽  
Elizabeth Sapey
Keyword(s):  
Lung Injury ◽  
Dual Role ◽  
Injury And Repair

The role of surgery in the cure of lung cancer

1967 ◽  
Vol 120 (2) ◽  
pp. 168-175 ◽  
Author(s):  
K. R. Boucot
Keyword(s):  
Lung Cancer
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