The Dual Role of Oxidative Stress in Lung Cancer

2019 ◽  
pp. 99-113
Author(s):  
Asmaa M. Ahmed
1997 ◽  
Vol 19 (9-10) ◽  
pp. 599-605 ◽  
Author(s):  
H. Farghali ◽  
S. Hynie ◽  
Z. Vohnikova ◽  
K. Masek

2015 ◽  
Author(s):  
Hung-Chi Cheng ◽  
Ming-Min Chang ◽  
Yau-Lin Tseng

2017 ◽  
Vol 12 (1) ◽  
pp. S713
Author(s):  
Frank Aboubakar Nana ◽  
Marylène Lecocq ◽  
Maha Ladjemi ◽  
Bruno Detry ◽  
Sebastien Dupasquier ◽  
...  

2017 ◽  
Vol 12 (11) ◽  
pp. S1931
Author(s):  
S. Sinicropi-Yao ◽  
J. Amann ◽  
K. Coombes ◽  
D. Carbone
Keyword(s):  

2021 ◽  
pp. 1-21
Author(s):  
Joytri Dutta ◽  
Sabita Singh ◽  
Ashish Jaiswal ◽  
Archita Ray ◽  
Pamelika Das ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Roman Fischer ◽  
Olaf Maier

Neuroinflammation and mitochondrial dysfunction are common features of chronic neurodegenerative diseases of the central nervous system. Both conditions can lead to increased oxidative stress by excessive release of harmful reactive oxygen and nitrogen species (ROS and RNS), which further promote neuronal damage and subsequent inflammation resulting in a feed-forward loop of neurodegeneration. The cytokine tumor necrosis factor (TNF), a master regulator of the immune system, plays an important role in the propagation of inflammation due to the activation and recruitment of immune cells via its receptor TNF receptor 1 (TNFR1). Moreover, TNFR1 can directly induce oxidative stress by the activation of ROS and RNS producing enzymes. Both TNF-induced oxidative stress and inflammation interact and cooperate to promote neurodegeneration. However, TNF plays a dual role in neurodegenerative disease, since stimulation via its second receptor, TNFR2, is neuroprotective and promotes tissue regeneration. Here we review the interrelation of oxidative stress and inflammation in the two major chronic neurodegenerative diseases, Alzheimer’s and Parkinson’s disease, and discuss the dual role of TNF in promoting neurodegeneration and tissue regeneration via its two receptors.


Author(s):  
Tzipora Goldkorn ◽  
Samuel Chung ◽  
Simone Filosto
Keyword(s):  

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