A new mouse model for Down syndrome

2003 ◽  
pp. 1-20 ◽  
Author(s):  
Y. Kazuki ◽  
T. C. Schulz ◽  
T. Shinohara ◽  
M. Kadota ◽  
R. Nishigaki ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model

scholarly journals Perturbation of fetal hematopoiesis in a mouse model of Down syndrome’s transient myeloproliferative disorder

Blood ◽  
2013 ◽  
Vol 122 (6) ◽  
pp. 988-998 ◽  
Author(s):  
Yehudit Birger ◽  
Liat Goldberg ◽  
Timothy M. Chlon ◽  
Benjamin Goldenson ◽  
Inna Muler ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Myeloproliferative Disorder ◽  
Transient Myeloproliferative Disorder ◽  
Terminal Domain ◽  
Key Points ◽  
Fetal Hematopoiesis ◽  
Fetal Erythropoiesis

Key Points Transient expansion of fetal megaerythroid progenitors in ERG/Gata1s mouse is biologically similar to Down syndrome TMD. The N-terminal domain of GATA1 and the downregulation of ERG expression are essential for normal fetal erythropoiesis.

scholarly journals Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model

2015 ◽  
Vol 138 ◽  
pp. 70-79 ◽  
Author(s):  
Megan Stringer ◽  
Irushi Abeysekera ◽  
Karl J. Dria ◽  
Randall J. Roper ◽  
Charles R. Goodlett
Keyword(s):  
Down Syndrome ◽  
Cognitive Impairment ◽  
Mouse Model ◽  
Low Dose ◽  
Egcg Treatment

scholarly journals Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome

2015 ◽  
Vol 77 ◽  
pp. 173-190 ◽  
Author(s):  
R.L. Nosheny ◽  
P.V. Belichenko ◽  
B.L. Busse ◽  
A.M. Weissmiller ◽  
V. Dang ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Synaptic Activation ◽  
Downstream Signaling

Global disruption of the cerebellar transcriptome in a Down syndrome mouse model

2003 ◽  
Vol 12 (16) ◽  
pp. 2013-2019 ◽  
Author(s):  
N. G. Saran
Keyword(s):  
Down Syndrome ◽  
Mouse Model

scholarly journals Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6brd1

2010 ◽  
Vol 206 (1) ◽  
pp. 52-62 ◽  
Author(s):  
Alberto C.S. Costa ◽  
Melissa R. Stasko ◽  
Cecilia Schmidt ◽  
Muriel T. Davisson
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Retinal Degeneration ◽  
Genetic Background ◽  
Ts65dn Mouse ◽  
Behavioral Validation
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