MF59: A safe and potent oil in water emulsion adjuvant for influenza vaccines, which induces enhanced protection against virus challenge

2008 ◽  
pp. 221-244 ◽  
Author(s):  
Derek T. O’Hagan ◽  
Audino Podda
Keyword(s):  
Influenza Vaccines ◽  
Water Emulsion ◽  
Virus Challenge ◽  
Oil In Water ◽  
Oil In Water Emulsion

Comparative pharmacokinetic and biodistribution study of two distinct squalene-containing oil-in-water emulsion adjuvants in H5N1 influenza vaccines

2019 ◽  
Vol 108 ◽  
pp. 104436 ◽  
Author(s):  
Million A. Tegenge ◽  
Linda S. Von Tungeln ◽  
Steven A. Anderson ◽  
Robert J. Mitkus ◽  
Michelle M. Vanlandingham ◽  
...  
Keyword(s):  
Biodistribution Study ◽  
Influenza Vaccines ◽  
Water Emulsion ◽  
Comparative Pharmacokinetic ◽  
H5n1 Influenza ◽  
Oil In Water ◽  
Oil In Water Emulsion

scholarly journals Oil-in-water emulsion adjuvants for pediatric influenza vaccines: a systematic review and meta-analysis

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu-Ju Lin ◽  
Chiao-Ni Wen ◽  
Ying-Ying Lin ◽  
Wen-Chi Hsieh ◽  
Chia-Chen Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Influenza Vaccines ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion

scholarly journals Comparative Immunogenicity Evaluation of Characterized Chitosan-Based and Other Adjuvants for Inactivated Influenza Vaccines

2016 ◽  
Vol 15 (1) ◽  
pp. 86-92
Author(s):  
L. M. Khantimirova ◽  
O. S. Kashirina ◽  
M. I. Chernikova ◽  
Y. M. Vasiliev
Keyword(s):  
Comparative Evaluation ◽  
Economic Feasibility ◽  
Influenza Vaccines ◽  
Water Emulsion ◽  
Deacetylation Degree ◽  
Physical Chemical ◽  
Oil In Water ◽  
H1n1 Strain ◽  
2009 H1n1 ◽  
Oil In Water Emulsion

Chitosan-based adjuvants combine effectiveness, safety and economic feasibility and thus are quite promising for enhancement of influenza control via vaccination, however, problems of characterization and reproducibility remain unresolved; data on relations between physical-chemical characteristics (PCC) of the polymer and immunogenicity of chitosan-based adjuvants, as well as comparative evaluation with other adjuvants are needed. Groups of mice were immunized intramuscularly with inactivated influenza vaccines based on A/California/07/2009 (H1N1) strain with characterized adjuvants based on chitosan with varying PCC (molecular mass 700 and 10 kDa, deacetylation degree 85%; HMC and LMC, respectively) and its derivative (succinylated chitosan (SC)). Experimental formulations were also studied: an «oil-in-water» emulsion (ME) and a multi-component adjuvant (MS). Different adjuvants increased immunogenicity of the inactivated influenza vaccines by hemagglutinin inhibiting sera antibodies in varying patterns. HMC was more immunogenic than LMC, whereas SC even reduced immunogenicity of the vaccine. HMC was comparable to MS by immunogenicity, and LMC - to ME. PCC of chitosan and its derivatives play an important role in immunogenicity of the respective adjuvants, and perspective and characterized chitosan-based adjuvants are comparable or even more immunogenic than adjuvants from other groups.

Dual CO2 Responsiveness of an Oil-In-Water Emulsion by Using Sodium Oleate and Water-Soluble Tertiary Amines

Langmuir ◽  
2021 ◽  
Author(s):  
Wenjing Ma ◽  
Shanshan Dai ◽  
Peiyao Zhu ◽  
Ru Zhou ◽  
Hongsheng Lu
Keyword(s):  
Sodium Oleate ◽  
Water Soluble ◽  
Tertiary Amines ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion
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