Mathematical Analysis of Extremity Immersion Cooling for Brain Temperature Management

2004 ◽  
pp. 98-101 ◽  
Author(s):  
Xiaojiang Xu ◽  
William Santee ◽  
Larry Berglund ◽  
Richard Gonzalez
Keyword(s):  
Mathematical Analysis ◽  
Brain Temperature ◽  
Temperature Management ◽  
Immersion Cooling

Survey of Brain Temperature Management in Patients with Traumatic Brain Injury in the Japan Neurotrauma Data Bank

2014 ◽  
Vol 31 (4) ◽  
pp. 315-320 ◽  
Author(s):  
Eiichi Suehiro ◽  
Hiroyasu Koizumi ◽  
Ichiro Kunitsugu ◽  
Hirosuke Fujisawa ◽  
Michiyasu Suzuki
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Temperature ◽  
Data Bank ◽  
Temperature Management

scholarly journals Insight into the use of tympanic temperature during target temperature management in emergency and critical care: a scoping review

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Michela Masè ◽  
Alessandro Micarelli ◽  
Marika Falla ◽  
Ivo B. Regli ◽  
Giacomo Strapazzon
Keyword(s):  
Core Temperature ◽  
Scoping Review ◽  
Brain Temperature ◽  
Temperature Measurements ◽  
Tympanic Temperature ◽  
Temperature Management ◽  
Target Temperature Management ◽  
Target Temperature ◽  
Temperature Changes ◽  
Clinical Conditions

Abstract Background Target temperature management (TTM) is suggested to reduce brain damage in the presence of global or local ischemia. Prompt TTM application may help to improve outcomes, but it is often hindered by technical problems, mainly related to the portability of cooling devices and temperature monitoring systems. Tympanic temperature (TTy) measurement may represent a practical, non-invasive approach for core temperature monitoring in emergency settings, but its accuracy under different TTM protocols is poorly characterized. The present scoping review aimed to collect the available evidence about TTy monitoring in TTM to describe the technique diffusion in various TTM contexts and its accuracy in comparison with other body sites under different cooling protocols and clinical conditions. Methods The scoping review was conducted following the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis extension for scoping reviews (PRISMA-ScR). PubMed, Scopus, and Web of Science electronic databases were systematically searched to identify studies conducted in the last 20 years, where TTy was measured in TTM context with specific focus on pre-hospital or in-hospital emergency settings. Results The systematic search identified 35 studies, 12 performing TTy measurements during TTM in healthy subjects, 17 in patients with acute cardiovascular events, and 6 in patients with acute neurological diseases. The studies showed that TTy was able to track temperature changes induced by either local or whole-body cooling approaches in both pre-hospital and in-hospital settings. Direct comparisons to other core temperature measurements from other body sites were available in 22 studies, which showed a faster and larger change of TTy upon TTM compared to other core temperature measurements. Direct brain temperature measurements were available only in 3 studies and showed a good correlation between TTy and brain temperature, although TTy displayed a tendency to overestimate cooling effects compared to brain temperature. Conclusions TTy was capable to track temperature changes under a variety of TTM protocols and clinical conditions in both pre-hospital and in-hospital settings. Due to the heterogeneity and paucity of comparative temperature data, future studies are needed to fully elucidate the advantages of TTy in emergency settings and its capability to track brain temperature.

Non-pharmacological neuroprotection in the ICU

2016 ◽  
Author(s):  
Niklas Nielsen ◽  
David B. Seder
Keyword(s):  
Brain Temperature ◽  
Surgical Techniques ◽  
Mass Effect ◽  
Neurological Injury ◽  
Temperature Management ◽  
Metabolic Disturbances ◽  
Surface Cooling ◽  
Vascular Abnormalities ◽  
Intravascular Devices ◽  
And Control

After control of the primary process causing acute neurological injury, further control of secondary injury pathways can be achieved by manipulating brain temperature, and achieving biochemical and metabolic homeostasis. Surgical techniques are routinely used to remove blood or trapped cerebrospinal fluid, control mass effect, or repair unstable vascular abnormalities. Therapeutic temperature management to a defined target can be achieved and maintained using cold fluids, ice packs, body surface cooling pads, and surface and intravascular devices with servo (feedback) mechanisms. Successful temperature management requires attentive surveillance and control of shivering and other potential complications, such as bleeding, infection, cardiac arrhythmias, and electrolyte and metabolic disturbances. Extremes of oxygenation and ventilation are associated with worse long-term functional outcomes, and should be avoided.

scholarly journals Temperature Monitoring With Zero Heat Flux Technology in Comparison With Thermocouple Needle Probe During Selective Hypothermia

2018 ◽  
Author(s):  
Mohammad Fazel Bakhsheshi ◽  
Lynn Keenliside ◽  
Ting-Yim Lee
Keyword(s):  
Brain Temperature ◽  
Cardiopulmonary Arrest ◽  
Core Body Temperature ◽  
Head Injuries ◽  
Extended Period ◽  
Accurate Method ◽  
Brain Parenchyma ◽  
Whole Body ◽  
Temperature Management ◽  
Great Promise

Hypothermia (brain temperature < 35°C) shows great promise to minimize neural damage in patients with cardiopulmonary arrest and traumatic head injuries.[1, 2] However, cooling the whole body below 33–34°C can induce severe complications.[3] Arrhythmia, infection and primary coagulopathy are the most commonly noted complications.[3] We have developed a Selective Brain Cooling (SBC) approach which can be initiated early after injury, induces rapid cooling and maintains the target brain temperature over an extended period of time before slowly rewarming without significantly affecting the core body temperature.[4] In our experiments, brain temperature was measured invasively by inserting a thermocouple probe into the brain parenchyma, which measured brain temperature accurately but is invasive, making it unsuitable for most patients. Invasive intracranial probe also can have complications such as intracranial hemorrhage or hematoma and infection.[5] Accordingly, the clinical adaptation of our SBC technique requires a reliable, non-invasive and accurate method for measuring local brain temperature so that cooling and rewarming rate can be controlled during targeted temperature management.

scholarly journals Mild Hyperthermia Aggravates Glucose Metabolic Consequences in Repetitive Concussion

2020 ◽  
Vol 21 (2) ◽  
pp. 609
Author(s):  
Meghan Blaya ◽  
Jessie Truettner ◽  
Weizhao Zhao ◽  
Helen Bramlett ◽  
William Dalton Dietrich
Keyword(s):  
Brain Injury ◽  
Glucose Metabolism ◽  
Brain Temperature ◽  
Brain Regions ◽  
Cerebral Glucose Metabolism ◽  
Temperature Management ◽  
Diagnostic Tools ◽  
Neurological Outcomes ◽  
The Impact ◽  
The Brain

Traumatic brain injury (TBI) is one of the leading causes of mortality and disability around the world. Mild TBI (mTBI) makes up approximately 80% of reported cases and often results in transient psychological abnormalities and cognitive disruption. At-risk populations for mTBI include athletes and other active individuals who may sustain repetitive concussive injury during periods of exercise and exertion when core temperatures are elevated. Previous studies have emphasized the impact that increased brain temperature has on adverse neurological outcomes. A lack of diagnostic tools to assess concussive mTBI limits the ability to effectively identify the post-concussive period during which the brain is uniquely susceptible to damage upon sustaining additional injury. Studies have suggested that a temporal window of increased vulnerability that exists corresponds to a period of injury-induced depression of cerebral glucose metabolism. In the current study, we sought to evaluate the relationship between repetitive concussion, local cerebral glucose metabolism, and brain temperature using the Marmarou weight drop model to generate mTBI. Animals were injured three consecutive times over a period of 7 days while exposed to either normothermic or hyperthermic temperatures for 15 min prior to and 1 h post each injury. A 14C-2-deoxy-d-glucose (2DG) autoradiography was used to measure local cerebral metabolic rate of glucose (lCMRGlc) in 10 diverse brain regions across nine bregma levels 8 days after the initial insult. We found that repetitive mTBI significantly decreased glucose utilization bilaterally in several cortical areas, such as the cingulate, visual, motor, and retrosplenial cortices, as well as in subcortical areas, including the caudate putamen and striatum, compared to sham control animals. lCMRGlc was significant in both normothermic and hyperthermic repetitive mTBI animals relative to the sham group, but to a greater degree when exposed to hyperthermic conditions. Taken together, we report significant injury-induced glucose hypometabolism after repetitive concussion in the brain, and additionally highlight the importance of temperature management in the acute period after brain injury.

scholarly journals Is Esophageal Temperature Better to Estimate Brain Temperature during Target Temperature Management in a Porcine Model of Cardiopulmonary Resuscitation?

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Heng Li ◽  
Zhengfei Yang ◽  
Yuanshan Liu ◽  
Zhixin Wu ◽  
Weibiao Pan ◽  
...  
Keyword(s):  
Brain Temperature ◽  
Temperature Management ◽  
Target Temperature Management ◽  
Central Vein ◽  
Target Temperature ◽  
Esophageal Temperature ◽  
Priority Method ◽  
Resuscitated Patients ◽  
Cost Efficient ◽  
Body Cooling

Brain temperature monitoring is important in target temperature management for comatose survivors after cardiac arrest. Since acquisition of brain temperature is invasive and unrealistic in scene of resuscitation, we tried to sought out surrogate sites of temperature measurements that can precisely reflect cerebral temperature. Therefore, we designed this controlled, randomized animal study to investigate whether esophageal temperature can better predict brain temperature in two different hypothermia protocols. The results indicated that esophageal temperature had a stronger correlation with brain temperature in the early phase of hypothermia in both whole and regional body cooling protocols. It means that esophageal temperature was considered as priority method for early monitoring once hypothermia is initiated. This clinical significance of this study is as follows. Since resuscitated patients have unstable hemodynamics, collecting temperature data from esophagus probe is cost-efficient and easier than the catheter in central vein. Moreover, it can prevent the risk of iatrogenic infection comparing with deep vein catheterization, especially in survivors with transient immunoexpressing in hypothermia protocol.

scholarly journals Brain temperature management in traumatic brain injury

2012 ◽  
Vol 45 (6) ◽  
pp. 167-171 ◽  
Author(s):  
Jinn-Rung Kuo ◽  
Chung-Ching Chio
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Temperature ◽  
Temperature Management

Density waves in disk galaxies

1967 ◽  
Vol 31 ◽  
pp. 313-317 ◽  
Author(s):  
C. C. Lin ◽  
F. H. Shu
Keyword(s):  
Mathematical Analysis ◽  
Spiral Structure ◽  
Stellar System ◽  
Collective Modes ◽  
Disk Galaxies ◽  
Spiral Pattern ◽  
Density Waves ◽  
The Galaxy ◽  
Detailed Mathematical Analysis

Density waves in the nature of those proposed by B. Lindblad are described by detailed mathematical analysis of collective modes in a disk-like stellar system. The treatment is centered around a hypothesis of quasi-stationary spiral structure. We examine (a) the mechanism for the maintenance of this spiral pattern, and (b) its consequences on the observable features of the galaxy.

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