Past three decades have seen the rapid development of high strength steel (HSS) in its application in structural engineering. However, so far the mechanical performance of a HSS beam-to-column connection has not been systematically studied, especially for bolted end-plate connections, the commonly employed beam-to-column connections in steel structures, which could restrict the application of HSS. Therefore, this paper aims to represent the basic methods, current achievements, recent applications, and the existing problems that lie in the way. In doing so, this paper is composed of three parts, experimental results, numerical analysis as well as component method. At the end, this paper indicates that future investigation should be based upon experimental analysis and proper finite element modeling, to verify a numerical model and to refine design standards.