Pathological effects of cyclosporin A in experimental models

Cyclosporin ◽  
1989 ◽  
pp. 303-323 ◽  
Author(s):  
Paul H. Whiting ◽  
Angus W. Thompson
Keyword(s):  
Cyclosporin A ◽  
Experimental Models

Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells

Blood ◽  
2006 ◽  
Vol 107 (3) ◽  
pp. 1018-1023 ◽  
Author(s):  
Jeroen J. A. Coenen ◽  
Hans J. P. M. Koenen ◽  
Esther van Rijssen ◽  
Luuk B. Hilbrands ◽  
Irma Joosten
Keyword(s):  
T Cells ◽  
Cyclosporin A ◽  
Tolerance Induction ◽  
Treg Cells ◽  
Immunosuppressive Drugs ◽  
Experimental Models ◽  
Naturally Occurring ◽  
Treg Population ◽  
Treg Subset

AbstractThe immunosuppressive drugs rapamycin and cyclosporin A (CsA) are widely used to prevent allograft rejection. Moreover, they were shown to be instrumental in experimental models of tolerance induction. However, it remains to be elucidated whether these drugs have an effect on the CD4+CD25+ regulatory T-cell (TREG) population, which plays an important role in allograft tolerance. Recently, we reported that alloantigen-driven expansion of human CD4+CD25+ TREGs gives rise to a distinct highly suppressive CD27+TREG subset next to a moderately suppressive CD27-TREG subset. In the current study we found that rapamycin and CsA do not interfere with the suppressive activity of human naturally occurring CD4+CD25+ T cells. However, in contrast to CsA, rapamycin preserved the dominance of the potent CD27+TREG subset over the CD27-TREG subset after alloantigen-driven expansion of CD4+CD25+ TREGs in vitro. Accordingly, CD4+CD25+ TREGs cultured in the presence of rapamycin displayed much stronger suppressive capacity than CD4+CD25+ TREGs cultured in the presence of CsA. In addition, CD4+CD25+ TREG cells cultured in the presence of rapamycin, but not CsA, were able to suppress ongoing alloimmune responses. This differential effect of rapamycin and CsA on the CD27+TREG subset dominance may favor the use of rapamycin in tolerance-inducing strategies.

ACE2 as therapeutic agent

2020 ◽  
Vol 134 (19) ◽  
pp. 2581-2595
Author(s):  
Qiuhong Li ◽  
Maria B. Grant ◽  
Elaine M. Richards ◽  
Mohan K. Raizada
Keyword(s):  
Therapeutic Agent ◽  
Renin Angiotensin System ◽  
Peptide Hormone ◽  
Experimental Models ◽  
Electrolyte Balance ◽  
Ang Ii ◽  
Angiotensin Converting Enzyme 2 ◽  
Beneficial Effects ◽  
Overwhelming Evidence ◽  
Future Challenges

Abstract The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance. ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to form Angiotensin-(1-7) (Ang-(1-7)), which binds to the G-protein–coupled Mas receptor and activates signaling pathways that counteract the pathways activated by Ang-II. ACE2 is expressed in a variety of tissues and overwhelming evidence substantiates the beneficial effects of enhancing ACE2/Ang-(1-7)/Mas axis under many pathological conditions in these tissues in experimental models. This review will provide a succinct overview on current strategies to enhance ACE2 as therapeutic agent, and discuss limitations and future challenges. ACE2 also has other functions, such as acting as a co-factor for amino acid transport and being exploited by the severe acute respiratory syndrome coronaviruses (SARS-CoVs) as cellular entry receptor, the implications of these functions in development of ACE2-based therapeutics will also be discussed.

Magnetic resonance imaging of renal transplants: its value in the differentiation of acute rejection and cyclosporin a nephrotoxicity

1988 ◽  
Vol 39 (2) ◽  
pp. 220-228
Author(s):  
L TESTRAKE ◽  
L SCHULTZEKOOL ◽  
L PAUL ◽  
A TEGZESS ◽  
J WEENINGS ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Acute Rejection ◽  
Cyclosporin A ◽  
Resonance Imaging ◽  
Renal Transplants

Curcumin, a natural phytochemical, inhibits pancreatic NF-kB and AP-1 activation and amellorates pancreatitis in two experimental models

2001 ◽  
Vol 120 (5) ◽  
pp. A537-A537
Author(s):  
I GUKOVSKY ◽  
C REYES ◽  
E VAQUERO ◽  
A BAYCHER ◽  
A GUKOVSKAYA ◽  
...  
Keyword(s):  
Experimental Models

1869: Combined Therapy of FR167653 and Cyclosporin A Significantly Prolonged Animal Survival in ratRenal Allografts

2004 ◽  
Vol 171 (4S) ◽  
pp. 493-494
Author(s):  
Haruhito Azuma ◽  
Shiro Takahara ◽  
Takashi Wada ◽  
Takeshi Sakamoto ◽  
Akihiko Okuyama ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Combined Therapy ◽  
Animal Survival

Experimental Models Of Ossiculoplasty

1994 ◽  
Vol 27 (4) ◽  
pp. 663-675 ◽  
Author(s):  
Richard L. Goode ◽  
Shinsei Nishihara
Keyword(s):  
Experimental Models

Experimental Models of CNS Infections: Contributions to Concepts of Disease and Treatment

1986 ◽  
Vol 4 (1) ◽  
pp. 249-264 ◽  
Author(s):  
M.G. Täuber ◽  
R.A. Brooks-Fournier ◽  
M.A. Sande
Keyword(s):  
Experimental Models ◽  
Cns Infections ◽  
Concepts Of Disease
Sign in / Sign up

Export Citation Format

Share Document