Tetrapeptide based inhibitors of p21 ras protein farnesyl transferase

Peptides ◽  
1994 ◽  
pp. 622-624
Author(s):  
K. Leftheris ◽  
T. Kline ◽  
W. Lau ◽  
L. Mueller ◽  
V. S. Goodfellow ◽  
...  
Keyword(s):  
Farnesyl Transferase ◽  
Ras Protein ◽  
P21 Ras ◽  
Protein Farnesyl Transferase

Synthesis of characteristic lipopeptides of the human N-Ras protein and their evaluation as possible inhibitors of protein farnesyl transferase

1997 ◽  
Vol 5 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Paul Stöber ◽  
Michael Schelhaas ◽  
Edgar Nägele ◽  
Patrizia Hagenbuch ◽  
János Rétey ◽  
...  
Keyword(s):  
Farnesyl Transferase ◽  
Ras Protein ◽  
Protein Farnesyl Transferase

Heteronemin as a Protein Farnesyl Transferase Inhibitor

2004 ◽  
Vol 42 (6) ◽  
pp. 454-456 ◽  
Author(s):  
Véronique Ledroit ◽  
Cécile Debitus ◽  
Frédéric Ausseil ◽  
Roselyne Raux ◽  
Jean-Louis Menou ◽  
...  
Keyword(s):  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase ◽  
Farnesyl Transferase Inhibitor

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 ◽  
Vol 3 (11) ◽  
pp. 2581-2585 ◽  
Author(s):  
B.M. Willumsen ◽  
K. Norris ◽  
A.G. Papageorge ◽  
N.L. Hubbert ◽  
D.R. Lowy
Keyword(s):  
Carboxy Terminus ◽  
Ras Protein ◽  
P21 Ras ◽  
Murine Sarcoma Virus ◽  
Sarcoma Virus ◽  
Murine Sarcoma

Farnesyl transferase inhibitors--a novel therapy for breast cancer.

2001 ◽  
pp. 227-235 ◽  
Author(s):  
S R Johnston ◽  
L R Kelland
Keyword(s):  
Breast Cancer ◽  
Therapeutic Strategy ◽  
Biological Effects ◽  
Cell Signalling ◽  
Novel Therapy ◽  
Farnesyl Transferase ◽  
Ras Protein ◽  
Oncogenic Ras ◽  
Cancer Models ◽  
Farnesyl Transferase Inhibitors

Inhibitors of the enzyme farnesyl protein transferase prevent a key step in the post-translational processing of the Ras protein, and were developed initially as a therapeutic strategy to inhibit cell signalling in ras-transformed cells. As more has been learnt about the biological effects of farnesyl transferase inhibitors (FTIs) on cancer cells, it is clear that tumours without oncogenic ras mutations such as breast cancer may also be targets for FTI therapy. This article reviews the rationale for the development of FTIs, focussing on early preclinical data in breast cancer models together with preliminary results from the first phase II study of an FTI in advanced breast cancer.

A Protein Farnesyl Transferase Involved in Abscisic Acid Signal Transduction in Arabidopsis

Science ◽  
1996 ◽  
Vol 273 (5279) ◽  
pp. 1239-1241 ◽  
Author(s):  
S. Cutler ◽  
M. Ghassemian ◽  
D. Bonetta ◽  
S. Cooney ◽  
P. McCourt
Keyword(s):  
Signal Transduction ◽  
Abscisic Acid ◽  
Farnesyl Transferase ◽  
Protein Farnesyl Transferase

Protein Farnesyl Transferase Target Selectivity Is Dependent upon Peptide Stimulated Product Release†

Biochemistry ◽  
2007 ◽  
Vol 46 (40) ◽  
pp. 11299-11309 ◽  
Author(s):  
Jerry M. Troutman ◽  
Douglas A. Andres ◽  
H. Peter Spielmann
Keyword(s):  
Farnesyl Transferase ◽  
Product Release ◽  
Protein Farnesyl Transferase

Expression of p21 ras protein as a prognostic factor in papillary thyroid cancer

1994 ◽  
Vol 30 (2) ◽  
pp. 171-174 ◽  
Author(s):  
Fulvio Basolo ◽  
Aldo Pinchera ◽  
Laura Fugazzola ◽  
Gabriella Fontanini ◽  
Rossella Elisei ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Prognostic Factor ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Ras Protein ◽  
P21 Ras
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