Hormones and Proliferative Activity in Breast Tissue

1991 ◽  
pp. 35-51 ◽  
Author(s):  
Irma H. Russo ◽  
Gloria Calaf ◽  
Jose Russo
Keyword(s):  
Proliferative Activity ◽  
Breast Tissue

scholarly journals Effect of Tamoxifen and Raloxifene on the Proliferative Activity of the Breast Epithelium in Premenopausal Women

2015 ◽  
Vol 9 ◽  
pp. CMO.S22456 ◽  
Author(s):  
Miliana T. Lucato ◽  
Ruffo Freitas-Junior ◽  
Marise A. R. Moreira ◽  
Júlio R. M. Bernardes-Junior ◽  
Sebastião A. Pinto ◽  
...  
Keyword(s):  
Proliferative Activity ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Premenopausal Women ◽  
Normal Breast ◽  
Surgical Removal ◽  
Breast Epithelium ◽  
Normal Breast Epithelium ◽  
Ki 67 ◽  
Significant Difference

Objectives To compare the effects of tamoxifen and raloxifene on the proliferative activity of normal breast tissue in premenopausal women as measured by Ki-67/MIB-1 expression. Study Design A total of 48 women with benign breast nodules and a recommendation for surgical removal of the lesion took part in this study. They were randomized to use tamoxifen or raloxifene for 22 days, after which they were submitted to surgery. During the surgical procedure, a 1-cm fragment of normal breast tissue was removed to study Ki-67 expression. Results The mean percentage ratios between immunolabeled and non-labeled cells were 2.02 ± 1.09 and 3.13 ± 3.23 for the tamoxifen and raloxifene groups, respectively. There was no statistically significant difference between the tamoxifen ( n = 16) and raloxifene ( n = 14) groups in relation to the immunohistochemical analysis of Ki-67 ( P = 0.205). Conclusion The results of this study showed no difference between tamoxifen and raloxifene with respect to the potential of these drugs to reduce the proliferative activity of the normal breast epithelium in premenopausal women.

Effect of a half dose of tamoxifen on proliferative activity in normal breast tissue

2000 ◽  
Vol 70 ◽  
pp. A86-A86
Author(s):  
J.R.M. Bernardes ◽  
M.T. Seixas ◽  
G.R. de Lima ◽  
E.C. Baracat ◽  
L.H. Gebrim
Keyword(s):  
Proliferative Activity ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Half Dose

Estimation of proliferative activity in normal postmenopausal breast tissue using core biopsy

The Breast ◽  
1999 ◽  
Vol 8 (1) ◽  
pp. 35-36
Author(s):  
C. Harper-Wynne ◽  
M.J. Hills ◽  
N. Nasiri ◽  
J. Salter ◽  
M. Dowsett
Keyword(s):  
Core Biopsy ◽  
Proliferative Activity ◽  
Breast Tissue

Increased proliferative activity and p53 expression in normal glandular breast tissue after radiation therapy

1998 ◽  
Vol 185 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Martijn Poeze ◽  
Maarten F. Von Meyenfeldt ◽  
Johannes L. Peterse ◽  
W. David George ◽  
Jos M. A. De Jong ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proliferative Activity ◽  
Breast Tissue ◽  
P53 Expression

Correlation of proliferative activity in breast tissue using PCNA/cyclin

1990 ◽  
Vol 21 (7) ◽  
pp. 781 ◽  
Author(s):  
S. Battersby ◽  
T.J. Anderson
Keyword(s):  
Proliferative Activity ◽  
Breast Tissue

Effect of a half dose of tamoxifen on proliferative activity in normal breast tissue

1999 ◽  
Vol 67 (1) ◽  
pp. 33-38 ◽  
Author(s):  
J.R.M. Bernardes ◽  
S. Nonogaki ◽  
M.T. Seixas ◽  
G. Rodrigues de Lima ◽  
E.C. Baracat ◽  
...  
Keyword(s):  
Proliferative Activity ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Half Dose

Dischidia nummularia – a potential plant for cytotoxicity and anti-proliferative activity

2019 ◽  
Author(s):  
M Khalil-ur-Rehman ◽  
EM Pferschy Wenzig ◽  
N Kretschmer ◽  
O Kunert ◽  
F Hofer ◽  
...  
Keyword(s):  
Proliferative Activity
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