Hepatic Parenchyma Transection Using Modern Instruments

Introduction: Micro-computed tomography with nanoparticle contrast agents may be a suitable tool for monitoring the time course of the development and progression of tumors. Here, we suggest a practical and convenient experimental method for generating and longitudinally imaging murine liver cancer models. Methods: Liver cancer was induced in 6 experimental mice by injecting clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeats-associated protein 9 plasmids causing mutations in genes expressed by hepatocytes. Nanoparticle agents are captured by Kupffer cells and detected by micro-computed tomography, thereby enabling longitudinal imaging. A total of 9 mice were used for the experiment. Six mice were injected with both plasmids and contrast, 2 injected with contrast alone, and one not injected with either agent. Micro-computed tomography images were acquired every 2- up to 14-weeks after cancer induction. Results: Liver cancer was first detected by micro-computed tomography at 8 weeks. The mean value of hepatic parenchymal attenuation remained almost unchanged over time, although the standard deviation of attenuation, reflecting heterogeneous contrast enhancement of the hepatic parenchyma, increased slowly over time in all mice. Histopathologically, heterogeneous distribution and aggregation of Kupffer cells was more prominent in the experimental group than in the control group. Heterogeneous enhancement of hepatic parenchyma, which could cause image quality deterioration and image misinterpretation, was observed and could be due to variation in Kupffer cells distribution. Conclusion: Micro-computed tomography with nanoparticle contrast is useful in evaluating the induction and characteristics of liver cancer, determining appropriate size of liver cancer for testing, and confirming therapeutic response.

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Parenchymal Guidewire Perforation during ERCP: An Unappreciated Injury

Case Reports in Surgery ◽

10.1155/2015/670323 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

M. Ezzedien Rabie ◽

Saad Al Faris ◽

Ali Nasser ◽

Abdul Aziz Shahir ◽

Yasser Al Mahdi ◽

...

Keyword(s):

Conservative Treatment ◽

Emergency Surgery ◽

Clinical Course ◽

The Other ◽

Clinical Deterioration ◽

Medical Community ◽

Successful Outcome ◽

Hepatic Parenchyma ◽

Pancreatic Parenchyma ◽

Intraperitoneal Drainage

ERCP is attended with certain complications, the majority of which are well known to the medical community. Other less-known complications also exist. Guidewire injury to the hepatic or pancreatic parenchyma represents one of the much less appreciated, albeit preventable, complications. In this report, we present the clinical course of three patients who sustained guidewire perforation of the pancreatic or hepatic parenchyma. In one patient, the clinical deterioration was confidently attributed to guidewire perforation of the pancreatic parenchyma. Conservative treatment was successful and unnecessary emergency surgery was thus avoided. In the other two, in whom the cause of the clinical deterioration was unclear, an emergency surgery was performed. Guidewire injury to the hepatic parenchyma was then confirmed which needed only intraperitoneal drainage, with successful outcome.

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Regression of Human Cirrhosis

Archives of Pathology & Laboratory Medicine ◽

10.5858/2000-124-1599-rohc ◽

2000 ◽

Vol 124 (11) ◽

pp. 1599-1607 ◽

Cited By ~ 15

Author(s):

Ian R. Wanless ◽

Eisuke Nakashima ◽

Morris Sherman

Keyword(s):

Portal Tract ◽

Point Of View ◽

Hepatic Parenchyma ◽

Normal Appearance ◽

Fibrosis Progression ◽

Regression Parameters ◽

Regenerative Nodules ◽

Piecemeal Necrosis ◽

Portal Tracts ◽

Incomplete Septal Cirrhosis

Abstract Context.—Cirrhosis is widely regarded as being irreversible. Recent studies have demonstrated that fibrosis may decrease with time in humans and experimental animals if the disease activity becomes quiescent. The histologic appearance of regressing cirrhosis in the human has not been described in detail. Objectives.—To define histologic parameters that indicate regression of cirrhosis and to provide an interpretation of how regression occurs from a histologic point of view. Design.—A patient who underwent a series of biopsies that showed apparent regression of hepatitis B cirrhosis is presented. In addition, 52 livers removed at transplantation having cirrhosis or incomplete septal cirrhosis were graded for histologic parameters that suggest progression or regression of fibrosis. Progression parameters were steatohepatitis, inflammation, bridging necrosis, and piecemeal necrosis. The regression parameters (collectively called the hepatic repair complex) were delicate perforated septa, isolated thick collagen fibers, delicate periportal fibrous spikes, portal tract remnants, hepatic vein remnants with prolapsed hepatocytes, hepatocytes within portal tracts or splitting septa, minute regenerative nodules, and aberrant parenchymal veins. Results and Conclusions.—Regression parameters were found in all livers and were prominent in the majority. Livers with micronodular cirrhosis, macronodular cirrhosis, and incomplete septal cirrhosis demonstrate a histologic continuum. A continuum of regressive changes was also seen within individual livers. These appearances allow one to understand visually how fibrous regions of hepatic parenchyma can be returned toward a normal appearance. Many examples of incomplete septal cirrhosis could be the product of regressed cirrhosis.

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Diffusion-weighted imaging of the pericholecystic hepatic parenchyma for distinguishing acute and chronic cholecystitis

Emergency Radiology ◽

10.1007/s10140-017-1548-9 ◽

2017 ◽

Vol 25 (1) ◽

pp. 7-11 ◽

Cited By ~ 1

Author(s):

Avneesh Gupta ◽

Christina A. LeBedis ◽

Jennifer Uyeda ◽

Mohammed M. Qureshi ◽

Stephan W. Anderson ◽

...

Keyword(s):

Diffusion Weighted Imaging ◽

Chronic Cholecystitis ◽

Hepatic Parenchyma ◽

Diffusion Weighted

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Histometrical Analysis of Hepatic Parenchyma in Normal and Cirrhotic Livers

The Tohoku Journal of Experimental Medicine ◽

10.1620/tjem.100.201 ◽

1970 ◽

Vol 100 (3) ◽

pp. 201-225 ◽

Cited By ~ 2

Author(s):

Masuo Kaneda ◽

Tohru Takahashi

Keyword(s):

Hepatic Parenchyma

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MR Imaging of Hepatocellular Carcinoma

Acta Radiologica ◽

10.1177/028418519503600211 ◽

1995 ◽

Vol 36 (2) ◽

pp. 163-167 ◽

Cited By ~ 7

Author(s):

H. Honda ◽

H. Onitsuka ◽

Y. Kanazawa ◽

T. Matsumata ◽

T. Hayashi ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Mr Imaging ◽

Low Grade ◽

Hepatic Parenchyma ◽

Grade Ii ◽

Paramagnetic Ions ◽

Grade Malignancy ◽

Histopathologic Findings ◽

Signal Intensities ◽

Grade Iii

In order to clarify the factors contributing to the signal intensities (SIs) of HCC on T1-weighted images, the amount of water, lipid, copper (Cu), iron (Fe), and manganese (Mn) was determined in HCC and surrounding hepatic parenchyma of 13 patients. The relationships among these findings, the histopathologic findings, and the SIs of T1-weighted images were evaluated. Among the 13 HCC, 3 had a high SI, 5 were isointense, and 5 had a low SI on T1-weighted images compared to the surrounding hepatic parenchyma. The paramagnetic ions which contributed to the SI patterns were assumed to be Cu in HCC (38.0±62.4 μg/g ww), and Fe in the liver (61.1±42.4 μg/g ww) and HCC (40.0±34.3 μg/g ww). In 8 HCC with high- or isointensity, 2 were grades I, 5 were grade II, and one was grade III according to the Edmondson-Steiner's histopathologic classification. It is concluded that the SI patterns alone can not be a sign of low grade malignancy because of the existence of Fe in livers and HCC.

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Resources of cryodestruction in the treatment of hepatocirrhosis

Bulletin of Siberian Medicine ◽

10.20538/1682-0363-2004-2-79-85 ◽

2004 ◽

Vol 3 (2) ◽

pp. 79-85

Author(s):

B. I. Alperovich ◽

A. V. Orlov ◽

Yu. V. Kiselyova

Keyword(s):

Chronic Hepatitis ◽

Carbon Tetrachloride ◽

Control Groups ◽

Hepatic Parenchyma ◽

Experimental Part ◽

And Control ◽

White Mongrel

The aim of investigation was to evaluate the liver cryodestruction effect on the course of chronic hepatitis and hepatocirrhosis. Experimental part of the investigation has been fulfilled on 220 white mongrel rats with toxic hepatocirrhosis caused by carbon tetrachloride. Evaluation of hepatic parenchyma state has been done by the following criteria: factor of parenchyma normalization and factor of sclerotization. The comparison of these factors in the basic and control groups has revealed an evident positive dynamics in normalization of histological hepatic structure.

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