Bioreactor Culture of Shoots and Somatic Embryos of Medicinal Plants for Production of Bioactive Compounds

Author(s):  
So-Young Park ◽  
Kee-Yoeup Paek
2021 ◽  
Vol 40 ◽  
pp. 03003
Author(s):  
Thanh-Tam Ho ◽  
Thi My Ngan Ha ◽  
Thi Kim Cuc Nguyen ◽  
Thanh Do Le

Plant tissue culture technology is a technique for aseptic culture of plant tissues under artificial culture conditions. It can be used as a means to directly mass-produce of bioactive compounds from different culture systems such as adventitious roots (ARs), hairy root, callus, somatic embryogenesis of medicinal plants. ARs cultures show high root proliferation, biomass production and have the potential to synthesize specific bioactive compounds. ARs can be induced in vitro from various explants, such as leaves, roots, stem, petiole callus, etc. Various parameters such as auxins, nitrous oxide, and light have shown to affect the morphogenesis of ARs. Air-lift bioreactors appear to be ideal for plant cell and organ cultures. They are suitable for the ARs culture of various medicinal plants. To scale-up ARs cultures, the Balloon type bubble bioreactor (BTBB) is reported to be a suitable system for the accumulation of both biomass and bioactive compounds production in numerous various medicinal plants. BTBB provides optimum conditions for growth and bioactive compound accumulation by efficiently controlling the culture environment, foam generation, reducing shear stress, and supplying optimal oxygen. This review summarized a strategy and approach for ARs culture for the production of biomass and secondary metabolites from laboratory to industrial scales by using air-lift bioreactor culture systems.


Agronomy ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2414
Author(s):  
Anna De De Carlo ◽  
Waed Tarraf ◽  
Maurizio Lambardi ◽  
Carla Benelli

The cultivation of medicinal plants and the production of bioactive compounds derived from them are of fundamental importance and interest, not only at the pharmacological level but also in nutraceutical and cosmetic industries and in functional foods, as well as plant protection in agriculture. In order to respond adequately to the increased demands of the global market from a quantitative and qualitative point of view and to guarantee environmental sustainability of the productions, it is necessary to resort to innovation tools, such as tissue culture in vitro technology. Nowadays, it is well known that the cultivation through the Temporary Immersion System (TIS) in a bioreactor has considerable advantages both for the in vitro mass production of the plants and for the production of secondary metabolites. The present review focuses on the application of TIS during the last two decades to produce biomass and bioactive compounds from medicinal plants. Indeed, almost one hundred papers are discussed, and they particularly focus on the effects of the culture system, vessel design and equipment, immersion time and frequency, and substrate composition for 88 medicinal species in TIS bioreactor culture.


2020 ◽  
Vol 26 (5) ◽  
pp. 519-541 ◽  
Author(s):  
Giovanna Ferrentino ◽  
Ksenia Morozova ◽  
Christine Horn ◽  
Matteo Scampicchio

Background: The use of essential oils is receiving increasing attention worldwide, as these oils are good sources of several bioactive compounds. Nowadays essential oils are preferred over synthetic preservatives thanks to their antioxidant and antimicrobial properties. Several studies highlight the beneficial effect of essential oils extracted from medicinal plants to cure human diseases such as hypertension, diabetes, or obesity. However, to preserve their bioactivity, the use of appropriate extraction technologies is required. Method: The present review aims to describe the studies published so far on the essential oils focusing on their sources and chemical composition, the technologies used for their recovery and their application as antioxidants in food products. Results: The review has been structured in three parts. In the first part, the main compounds present in essential oils extracted from medicinal plants have been listed and described. In the second part, the most important technologies used for extraction and distillation, have been presented. In detail, conventional methods have been described and compared with innovative and green technologies. Finally, in the last part, the studies related to the application of essential oils as antioxidants in food products have been reviewed and the main findings discussed in detail. Conclusions: In summary, an overview of the aforementioned subjects is presented by discussing the results of the most recent published studies.


2020 ◽  
Vol 26 ◽  
Author(s):  
Kondeti Ramudu Shanmugam ◽  
Bhasha Shanmugam ◽  
Gangigunta Venkatasubbaiah ◽  
Sahukari Ravi ◽  
Kesireddy Sathyavelu Reddy

Background : Diabetes is a major public health problem in the world. It affects each and every part of the human body and also leads to organ failure. Hence, great progress made in the field of herbal medicine and diabetic research. Objectives: Our review will focus on the effect of bioactive compounds of medicinal plants which are used to treat diabetes in India and other countries. Methods: Information regarding diabetes, oxidative stress, medicinal plants and bioactive compounds were collected from different search engines like Science direct, Springer, Wiley online library, Taylor and francis, Bentham Science, Pubmed and Google scholar. Data was analyzed and summarized in the review. Results and Conclusion: Anti-diabetic drugs that are in use have many side effects on vital organs like heart, liver, kidney and brain. There is an urgent need for alternative medicine to treat diabetes and their disorders. In India and other countries herbal medicine was used to treat diabetes. Many herbal plants have antidiabetic effects. The plants like ginger, phyllanthus, curcumin, aswagandha, aloe, hibiscus and curcuma showed significant anti-hyperglycemic activities in experimental models and humans. The bioactive compounds like Allicin, azadirachtin, cajanin, curcumin, querceitin, gingerol possesses anti-diabetic, antioxidant and other pharmacological properties. This review focuses on the role of bioactive compounds of medicinal plants in prevention and management of diabetes. Conclusion: Moreover, our review suggests that bioactive compounds have the potential therapeutic potential against diabetes. However, further in vitro and in vivo studies are needed to validate these findings.


Biology ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 634
Author(s):  
Francisco Les ◽  
Guillermo Cásedas ◽  
Víctor López

Nature is an inexhaustible source of bioactive compounds and products with interesting medicinal properties and technological applications [...]


2022 ◽  
pp. 107184
Author(s):  
Rodrigo F. da Silva ◽  
Candice N. Carneiro ◽  
Cheila B. do C. de Sousa ◽  
Federico J. V. Gomez ◽  
Magdalena Espino ◽  
...  

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