Classification of Drug Delivery Systems

Nearly 40% of novel chemical entities show evidence of low solubility in water and low bioavailability. Self-emulsifying formulations have showed the power to improve the bioavailability of hydrophobic drugs. Self-emulsifying formulations belong to lipid formulations, and their size range from 100 nm in case of self-emulsifying drug delivery systems and less than 50 nm in case of self-microemulsifying drug delivery systems. In general self-emulsifying formulations s represent isotropic mixtures of oils, surfactants and co-surfactants, which emulsify spontaneous in aqueous media under conditions of gentle stirring. Usually self-emulsifying formulations presented liquids, which fill the soft gelatinous capsules. However, the dosage form has drawbacks, especially in the production process. In this regard, the use of the methodology of solidification of liquid or semi-solid components of self-emulsifying formulations and their transformation into powders for the preparation of solid dosage forms is relevant. This paper summarizes the main features, a classification of lipid forms, auxiliary substances for the preparation of self-emulsifying formulations, techniques of solidification, the phases of the development of self-emulsifying formulations, evaluation of parameters of quality of liquid and solid self-emulsifying formulations, approaches to development of medicinal forms on the basis of the self-emulsifying formulations, as well as an overview of the drugs, presented on the market in the form of self-emulsifying formulations.

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Biomedical Nanotechnology

Research Anthology on Emerging Technologies and Ethical Implications in Human Enhancement ◽

10.4018/978-1-7998-8050-9.ch033 ◽

2021 ◽

pp. 634-662

Author(s):

Pınar Çakır Hatır

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Controlled Release ◽

Drug Delivery Systems ◽

Point Of Care ◽

Lab On A Chip ◽

Delivery Systems ◽

History Of ◽

Measurement Devices

This chapter aims to provide an overview of recent studies in the field of biomedical nanotechnology, which is described as the combination of biology and nanotechnology. The field includes innovations such as the improvement of biological processes at the nanoscale, the development of specific biomaterials, and the design of accurate measurement devices. Biomedical nanotechnology also serves areas like the development of intelligent drug delivery systems and controlled release systems, tissue engineering, nanorobotics (nanomachines), lab-on-a-chip, point of care, and nanobiosensor development. This chapter will mainly cover the biomedical applications of nanotechnology under the following titles: the importance of nanotechnology, the history of nanotechnology, classification of nanostructures, inorganic, polymer and composite nanostructures, fabrication of nanomaterials, applications of nanostructures, the designs of intelligent drug delivery systems and controlled release systems, bioimaging, bioseparation, nano-biomolecules, lab-on-a-chip, point of care, nanobiosensor development, tissue engineering and the future of biomedical nanotechnology.

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Biomedical Nanotechnology

Biomedical and Clinical Engineering for Healthcare Advancement - Advances in Bioinformatics and Biomedical Engineering ◽

10.4018/978-1-7998-0326-3.ch003 ◽

2020 ◽

pp. 30-65

Author(s):

Pınar Çakır Hatır

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Controlled Release ◽

Drug Delivery Systems ◽

Point Of Care ◽

Lab On A Chip ◽

Delivery Systems ◽

History Of ◽

Measurement Devices

This chapter aims to provide an overview of recent studies in the field of biomedical nanotechnology, which is described as the combination of biology and nanotechnology. The field includes innovations such as the improvement of biological processes at the nanoscale, the development of specific biomaterials, and the design of accurate measurement devices. Biomedical nanotechnology also serves areas like the development of intelligent drug delivery systems and controlled release systems, tissue engineering, nanorobotics (nanomachines), lab-on-a-chip, point of care, and nanobiosensor development. This chapter will mainly cover the biomedical applications of nanotechnology under the following titles: the importance of nanotechnology, the history of nanotechnology, classification of nanostructures, inorganic, polymer and composite nanostructures, fabrication of nanomaterials, applications of nanostructures, the designs of intelligent drug delivery systems and controlled release systems, bioimaging, bioseparation, nano-biomolecules, lab-on-a-chip, point of care, nanobiosensor development, tissue engineering and the future of biomedical nanotechnology.

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Classification of stimuli–responsive polymers as anticancer drug delivery systems

Drug Delivery ◽

10.3109/10717544.2014.887157 ◽

2014 ◽

Vol 22 (2) ◽

pp. 145-155 ◽

Cited By ~ 61

Author(s):

Bita Taghizadeh ◽

Shahrouz Taranejoo ◽

Seyed Ali Monemian ◽

Zoha Salehi Moghaddam ◽

Karim Daliri ◽

...

Keyword(s):

Drug Delivery ◽

Anticancer Drug ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Stimuli Responsive ◽

Anticancer Drug Delivery ◽

Stimuli Responsive Polymers ◽

Responsive Polymers

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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