scholarly journals Mammary gland development: cell fate specification, stem cells and the microenvironment

Development ◽  
2015 ◽  
Vol 142 (6) ◽  
pp. 1028-1042 ◽  
Author(s):  
J. L. Inman ◽  
C. Robertson ◽  
J. D. Mott ◽  
M. J. Bissell
Keyword(s):  
Stem Cells ◽  
Mammary Gland ◽  
Cell Fate ◽  
Mammary Gland Development ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Gland Development

scholarly journals Plasticity and Potency of Mammary Stem Cell Subsets During Mammary Gland Development

2019 ◽  
Vol 20 (9) ◽  
pp. 2357 ◽  
Author(s):  
Eunmi Lee ◽  
Raziye Piranlioglu ◽  
Max S. Wicha ◽  
Hasan Korkaya
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Mammary Epithelial ◽  
Stem Cell Markers ◽  
Quiescent State ◽  
Mammary Stem Cells ◽  
Mammary Stem ◽  
Gland Development

It is now widely believed that mammary epithelial cell plasticity, an important physiological process during the stages of mammary gland development, is exploited by the malignant cells for their successful disease progression. Normal mammary epithelial cells are heterogeneous and organized in hierarchical fashion, in which the mammary stem cells (MaSC) lie at the apex with regenerative capacity as well as plasticity. Despite the fact that the majority of studies supported the existence of multipotent MaSCs giving rise to both basal and luminal lineages, others proposed lineage restricted unipotent MaSCs. Consistent with the notion, the latest research has suggested that although normal MaSC subsets mainly stay in a quiescent state, they differ in their reconstituting ability, spatial localization, and molecular and epigenetic signatures in response to physiological stimuli within the respective microenvironment during the stages of mammary gland development. In this review, we will focus on current research on the biology of normal mammary stem cells with an emphasis on properties of cellular plasticity, self-renewal and quiescence, as well as the role of the microenvironment in regulating these processes. This will include a discussion of normal breast stem cell heterogeneity, stem cell markers, and lineage tracing studies.

scholarly journals A noncoding RNA is a potential marker of cell fate during mammary gland development

2006 ◽  
Vol 103 (15) ◽  
pp. 5781-5786 ◽  
Author(s):  
M. R. Ginger ◽  
A. N. Shore ◽  
A. Contreras ◽  
M. Rijnkels ◽  
J. Miller ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Cell Fate ◽  
Noncoding Rna ◽  
Mammary Gland Development ◽  
Potential Marker ◽  
Gland Development

Distinct stem cells contribute to mammary gland development and maintenance

Nature ◽  
2011 ◽  
Vol 479 (7372) ◽  
pp. 189-193 ◽  
Author(s):  
Alexandra Van Keymeulen ◽  
Ana Sofia Rocha ◽  
Marielle Ousset ◽  
Benjamin Beck ◽  
Gaëlle Bouvencourt ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mammary Gland ◽  
Mammary Gland Development ◽  
Gland Development

scholarly journals Notch Signaling Alters Sensory or Neuronal Cell Fate Specification of Inner Ear Stem Cells

2011 ◽  
Vol 31 (23) ◽  
pp. 8351-8358 ◽  
Author(s):  
S.-J. Jeon ◽  
M. Fujioka ◽  
S.-C. Kim ◽  
A. S. B. Edge
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Inner Ear ◽  
Cell Fate ◽  
Neuronal Cell ◽  
Cell Fate Specification ◽  
Fate Specification
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