scholarly journals High glucose alters the expression of genes involved in proliferation and cell-fate specification of embryonic neural stem cells

Diabetologia ◽  
2006 ◽  
Vol 49 (5) ◽  
pp. 1027-1038 ◽  
Author(s):  
J. Fu ◽  
S. S. W. Tay ◽  
E. A. Ling ◽  
S. T. Dheen
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cell Fate ◽  
High Glucose ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Expression Of Genes

Role of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells

2018 ◽  
Vol 55 (9) ◽  
pp. 7107-7117 ◽  
Author(s):  
Raquel Coronel ◽  
Adela Bernabeu-Zornoza ◽  
Charlotte Palmer ◽  
Mar Muñiz-Moreno ◽  
Alberto Zambrano ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Amyloid Precursor Protein ◽  
Cell Fate ◽  
Precursor Protein ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs

2015 ◽  
Vol 43 (5) ◽  
pp. 2638-2654 ◽  
Author(s):  
Sarah Nicklas ◽  
Satoshi Okawa ◽  
Anna-Lena Hillje ◽  
Laura González-Cano ◽  
Antonio del Sol ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cell Fate ◽  
Rna Helicase ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals Notch Signaling Alters Sensory or Neuronal Cell Fate Specification of Inner Ear Stem Cells

2011 ◽  
Vol 31 (23) ◽  
pp. 8351-8358 ◽  
Author(s):  
S.-J. Jeon ◽  
M. Fujioka ◽  
S.-C. Kim ◽  
A. S. B. Edge
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Inner Ear ◽  
Cell Fate ◽  
Neuronal Cell ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms

2015 ◽  
Vol 17 (3) ◽  
pp. 300-315 ◽  
Author(s):  
Lluis Morey ◽  
Alexandra Santanach ◽  
Enrique Blanco ◽  
Luigi Aloia ◽  
Elphège P. Nora ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cell Fate ◽  
Embryonic Stem ◽  
Cell Fate Specification ◽  
Mesoderm Cell ◽  
Fate Specification

scholarly journals Mammary gland development: cell fate specification, stem cells and the microenvironment

Development ◽  
2015 ◽  
Vol 142 (6) ◽  
pp. 1028-1042 ◽  
Author(s):  
J. L. Inman ◽  
C. Robertson ◽  
J. D. Mott ◽  
M. J. Bissell
Keyword(s):  
Stem Cells ◽  
Mammary Gland ◽  
Cell Fate ◽  
Mammary Gland Development ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Gland Development

scholarly journals Gene regulatory networks controlling temporal patterning, neurogenesis and cell fate specification in the mammalian retina.

2021 ◽  
Author(s):  
Pin Lyu ◽  
Thanh Hoang ◽  
Clayton P Santiago ◽  
Eric Thomas ◽  
Andrew Timms ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Cell Fate ◽  
Gene Regulatory Networks ◽  
Regulatory Networks ◽  
Cell Fate Specification ◽  
Cell Type ◽  
Temporal Patterning ◽  
Fate Specification ◽  
Expression Of Genes ◽  
Gene Regulatory

Gene regulatory networks (GRNs), consisting of transcription factors and their target cis-regulatory sequences, control neurogenesis and cell fate specification in the developing central nervous system, but their organization is poorly characterized. In this study, we performed integrated scRNA-seq and scATAC-seq analysis from both mouse and human retina to profile dynamic changes in gene expression, chromatin accessibility and transcription factor footprinting during retinal neurogenesis. We identified multiple interconnected, evolutionarily-conserved GRNs consisting of cell type-specific transcription factors that both activate expression of genes within their own network and often inhibit expression of genes in other networks. These GRNs control state transitions within primary retinal progenitors that underlie temporal patterning, regulate the transition from primary to neurogenic progenitors, and drive specification of each major retinal cell type. We confirmed the prediction of this analysis that the NFI transcription factors Nfia, Nfib, and Nfix selectively activate expression of genes that promote late-stage temporal identity in primary retinal progenitors. We also used GRNs to identify additional transcription factors that selectively promote (Insm1/2) and inhibit (Tbx3, Tcf7l1/2) rod photoreceptor specification in postnatal retina. This study provides an inventory of cis- and trans-acting factors that control retinal development, identifies transcription factors that control the temporal identity of retinal progenitors and cell fate specification, and will potentially help guide cell-based therapies aimed at replacing retinal neurons lost due to disease.

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