Multimodality Treatment for Colorectal Peritoneal Metastases

2017 ◽  
pp. 281-316
Author(s):  
Aditi Bhatt ◽  
Sanket Mehta ◽  
François Quénet
Keyword(s):  
Multimodality Treatment ◽  
Peritoneal Metastases

scholarly journals Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research

2019 ◽  
Vol 2019 ◽  
pp. 1-30 ◽  
Author(s):  
Foteini Stefania Koumpa ◽  
Diamantis Xylas ◽  
Maciej Konopka ◽  
Dieter Galea ◽  
Kirill Veselkov ◽  
...  
Keyword(s):  
Systematic Review ◽  
English Language ◽  
Early Stage ◽  
Multimodality Treatment ◽  
Peritoneal Metastases ◽  
Future Research ◽  
Model Studies ◽  
Language Studies ◽  
Translational Biomarkers

Colorectal peritoneal metastases (CPM) are associated with abbreviated survival and significantly impaired quality of life. In patients with CPM, radical multimodality treatment consisting of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has demonstrated oncological superiority over systemic chemotherapy alone. In highly selected patients undergoing CRS + HIPEC, overall survival of over 60% has been reported in some series. These are patients in whom the disease burden is limited and where the diagnosis is made at an early stage in the disease course. Early diagnosis and a deeper understanding of the biological mechanisms that regulate CPM are critical to refining patient selection for radical treatment, personalising therapeutic approaches, enhancing prognostication, and ultimately improving long-term survivorship. In the present study, we outline three broad themes which represent critical future research targets in CPM: (1) enhanced radiological strategies for early detection and staging; (2) identification and validation of translational biomarkers for diagnostic, prognostic, and therapeutic deployment; and (3) development of optimized approaches for surgical cytoreduction as well as more precise strategies for intraperitoneal drug selection and delivery. Herein, we provide a contemporary narrative review of the state of the art in these three areas. A systematic review in accordance with PRISMA guidelines was undertaken on all English language studies published between 2007 and 2017. In vitro and animal model studies were deemed eligible for inclusion in the sections pertaining to biomarkers and therapeutic optimisation, as these areas of research currently remain in the early stages of development. Acquired data were then divided into hierarchical thematic categories (imaging modalities, translational biomarkers (diagnostic/prognostic/therapeutic), and delivery techniques) and subcategories. An interactive sunburst figure is provided for intuitive interrogation of the CPM research landscape.

Laparoscopy as a useful selection tool for patients with prior surgery and peritoneal metastases suitable for multimodality treatment strategies

2017 ◽  
Vol 32 (5) ◽  
pp. 2288-2294 ◽  
Author(s):  
Philipp von Breitenbuch ◽  
Thomas Boerner ◽  
Tonia Jeiter ◽  
Pompiliu Piso ◽  
Hans J. Schlitt
Keyword(s):  
Treatment Strategies ◽  
Multimodality Treatment ◽  
Peritoneal Metastases ◽  
Selection Tool ◽  
Prior Surgery

Multimodality treatment of hepatocellular carcinoma

1998 ◽  
Vol 13 (11-s4) ◽  
pp. S315-S319 ◽  
Author(s):  
ZHAO-YOU TANG ◽  
XIN-DA ZHOU ◽  
ZENG-CHEN MA ◽  
ZHI-QUAN WU ◽  
JIA FAN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multimodality Treatment

Multimodality Treatment of 15 Malignant WHO III (2007 Criteria) Meningiomas: Differential Survival Rates Between De Novo and Progressive Origins

2014 ◽  
Vol 75 (S 01) ◽  
Author(s):  
Philip Tatman ◽  
Joshua Osbun ◽  
Owais Ahmad ◽  
Maciej Mrugala ◽  
Jason Rockhill ◽  
...  
Keyword(s):  
De Novo ◽  
Survival Rates ◽  
Multimodality Treatment ◽  
Differential Survival

Multimodality Treatment and Survival in Sinonasal Minor Salivary Gland Tumors

2019 ◽  
Author(s):  
Sina Torabi ◽  
Todd Spock ◽  
Bruno Cardoso ◽  
Janet Chao ◽  
R. Manes ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Minor Salivary Gland ◽  
Multimodality Treatment ◽  
Salivary Gland Tumors ◽  
Minor Salivary Gland Tumors

Petroclival Meningiomas: Multimodality Treatment and Outcomes at Long-Term Follow-Up

Skull Base ◽  
2007 ◽  
Vol 17 (S 2) ◽  
Author(s):  
Sabareesh Natarajan ◽  
Laligam Sekhar ◽  
David Schessel ◽  
Akio Morita
Keyword(s):  
Multimodality Treatment ◽  
Petroclival Meningiomas ◽  
Long Term Follow Up
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