Graphene-Based Nanocomposites as Promising Options for Hard Tissue Regeneration

2018 ◽  
pp. 103-117 ◽  
Author(s):  
Yong Cheol Shin ◽  
Su-Jin Song ◽  
Seung Jo Jeong ◽  
Bongju Kim ◽  
Il Keun Kwon ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Hard Tissue

scholarly journals 3D-printed gelatin methacrylate (GelMA)/silanated silica scaffold assisted by two-stage cooling system for hard tissue regeneration

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Eunjeong Choi ◽  
Dongyun Kim ◽  
Donggu Kang ◽  
Gi Hoon Yang ◽  
Bongsu Jung ◽  
...  
Keyword(s):  
Osteogenic Differentiation ◽  
Tissue Regeneration ◽  
Cooling System ◽  
Composite Scaffold ◽  
Human Mesenchymal Stem Cells ◽  
Temperature Control System ◽  
Process Conditions ◽  
Hard Tissue ◽  
Two Stage ◽  
3D Printed

Abstract Among many biomaterials, gelatin methacrylate (GelMA), a photocurable protein, has been widely used in 3D bioprinting process owing to its excellent cellular responses, biocompatibility and biodegradability. However, GelMA still shows a low processability due to the severe temperature dependence of viscosity. To overcome this obstacle, we propose a two-stage temperature control system to effectively control the viscosity of GelMA. To optimize the process conditions, we evaluated the temperature of the cooling system (jacket and stage). Using the established system, three GelMA scaffolds were fabricated in which different concentrations (0, 3 and 10 wt%) of silanated silica particles were embedded. To evaluate the performances of the prepared scaffolds suitable for hard tissue regeneration, we analyzed the physical (viscoelasticity, surface roughness, compressive modulus and wettability) and biological (human mesenchymal stem cells growth, western blotting and osteogenic differentiation) properties. Consequently, the composite scaffold with greater silica contents (10 wt%) showed enhanced physical and biological performances including mechanical strength, cell initial attachment, cell proliferation and osteogenic differentiation compared with those of the controls. Our results indicate that the GelMA/silanated silica composite scaffold can be potentially used for hard tissue regeneration.

scholarly journals In Vitro and Ex Vivo Analysis of Collagen Foams for Soft and Hard Tissue Regeneration

In Vivo ◽  
2021 ◽  
Vol 35 (5) ◽  
pp. 2541-2549
Author(s):  
OLE JUNG ◽  
MIKE BARBECK ◽  
LU FAN ◽  
FABIAN KORTE ◽  
CUIFENG ZHAO ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Ex Vivo ◽  
Hard Tissue

Three-dimensional cell printed lock-key structure for oral soft and hard tissue regeneration

2021 ◽  
Author(s):  
Shihan Zhang ◽  
qing li ◽  
Peng Liu ◽  
Chunping Lin ◽  
Zhihui Tang ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Three Dimensional ◽  
Hard Tissue ◽  
Dimensional Cell

Chapter 12. 3D Bioprinting Hydrogel for Hard Tissue Regeneration

2021 ◽  
pp. 316-338
Author(s):  
Baosen Tan ◽  
Wenyong Liu ◽  
Shaolong Kuang ◽  
Xiaoming Li
Keyword(s):  
Tissue Regeneration ◽  
3D Bioprinting ◽  
Hard Tissue

Analysis of hard tissue regeneration and Wnt signalling in dental pulp tissues after direct pulp capping with different materials

2019 ◽  
Vol 52 (11) ◽  
pp. 1605-1616 ◽  
Author(s):  
K. Yaemkleebbua ◽  
T. Osathanon ◽  
N. Nowwarote ◽  
C. N. Limjeerajarus ◽  
W. Sukarawan
Keyword(s):  
Tissue Regeneration ◽  
Dental Pulp ◽  
Wnt Signalling ◽  
Direct Pulp Capping ◽  
Hard Tissue ◽  
Pulp Capping

scholarly journals A review of protein adsorption on bioceramics

2012 ◽  
Vol 2 (3) ◽  
pp. 259-277 ◽  
Author(s):  
Kefeng Wang ◽  
Changchun Zhou ◽  
Youliang Hong ◽  
Xingdong Zhang
Keyword(s):  
Tissue Regeneration ◽  
Protein Interactions ◽  
Tissue Repair ◽  
Cellular Response ◽  
Biological Activities ◽  
Biological Mechanisms ◽  
Hard Tissue ◽  
Coated Layer ◽  
Sense And Respond

Bioceramics, because of its excellent biocompatible and mechanical properties, has always been considered as the most promising materials for hard tissue repair. It is well know that an appropriate cellular response to bioceramics surfaces is essential for tissue regeneration and integration. As the in vivo implants, the implanted bioceramics are immediately coated with proteins from blood and body fluids, and it is through this coated layer that cells sense and respond to foreign implants. Hence, the adsorption of proteins is critical within the sequence of biological activities. However, the biological mechanisms of the interactions of bioceramics and proteins are still not well understood. In this review, we will recapitulate the recent studies on the bioceramic–protein interactions.

scholarly journals Electrospinning of Nanofibers for Tissue Engineering Applications

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Haifeng Liu ◽  
Xili Ding ◽  
Gang Zhou ◽  
Ping Li ◽  
Xing Wei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
Fiber Morphology ◽  
Hard Tissue ◽  
Nanoscale Material ◽  
Considerable Potential ◽  
Recent Interest ◽  
Material Fabrication

Electrospinning is a method in which materials in solution are formed into nano- and micro-sized continuous fibers. Recent interest in this technique stems from both the topical nature of nanoscale material fabrication and the considerable potential for use of these nanoscale fibres in a range of applications including, amongst others, a range of biomedical applications processes such as drug delivery and the use of scaffolds to provide a framework for tissue regeneration in both soft and hard tissue applications systems. The objectives of this review are to describe the theory behind the technique, examine the effect of changing the process parameters on fiber morphology, and discuss the application and impact of electrospinning on the fields of vascular, neural, bone, cartilage, and tendon/ligament tissue engineering.

scholarly journals Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regeneration

2012 ◽  
Vol 26 (11) ◽  
pp. 4517-4529 ◽  
Author(s):  
Li‐Na Niu ◽  
Kai Jiao ◽  
Yi‐Pin Qi ◽  
Sergey Nikonov ◽  
Cynthia K. Y. Yiu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Sustained Release ◽  
Tissue Regeneration ◽  
Hard Tissue ◽  
Collagen Scaffolds ◽  
Cell Homing ◽  
Stem Cell Homing
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