Anatomy of the Stomach and Surrounding Structures, Part I: For Those Who Seek Theoretical Basis Through Understanding of Developmental Process

2020 ◽  
pp. 1-19 ◽  
Author(s):  
Hisashi Shinohara
PEDIATRICS ◽  
1974 ◽  
Vol 53 (5) ◽  
pp. 824-825
Author(s):  
Albert Dorfman

Perhaps some of the comments already made here about developing a theoretical basis for predictive purposes were in disagreement because opportunities vary greatly with the model under discussion. Certainly the general lesson of molecular biology and biochemistry in the last two decades has been surprisingly opposite to that of toxicology in that metabolic pathways are remarkably similar in range, not merely from mouse to man but even from bacteria to man. It is at times hard to accept the claim that animal models are not too useful for studying teratogenesis. Some principles that have been reviewed today are worth summarizing, because if one thinks of certain parameters, such as the final toxic substance (frequently a metabolite of the original pollutant) there is probably not much difference among various species or organisms. At least so it seems from study of enzyme systems. If one considers simpler situations, such as mercury pollution, he can realize the validity of this concept. THREE PARAMETERS OF TOXICITY One could possibly look at the situation as follows: at various stages of the developmental process, starting from the fertilized ovum and progressing to the mature organism or even the aged organism, there are enzymological differences which have become of interest in developmental biology. In particular, in pediatrics we know about programmed processes that go forward inevitably, and others which are subject to control by hormonal influences, by administration of certain substances, or by induction. In the interpretation of any kind of toxic effect, we must consider if our developmental parameter will or will not be toxic at certain stages of development, as I will ifiustrate later.


2016 ◽  
Vol 44 (4) ◽  
pp. 1651-1677 ◽  
Author(s):  
Jeremy L. Schoen ◽  
Jennifer Lynn Bowler ◽  
Marieke Catharine Schilpzand

The innovations of creative individuals are regarded as vital for business functioning and survival. To this end, efforts have been made to design measures of creative personality in hopes of predicting creative performance. Current measures of creative personality all reside at the explicit level, yet theory and research both suggest that a large proportion of personality can also be conceptualized at the implicit level. We address this issue by presenting a theoretical basis for creative personality that operates on an implicit level. Using conditional reasoning methodology, we describe five cognitive biases that serve as justification mechanisms for creative personality. Next, we link implicit creative personality to creative abilities through a developmental process. We then test this model and our new measure of creative personality in five different studies. Our results provide evidence in support of an implicit component of creative personality and suggest that it is a substantial predictor of creative performance. Finally, we describe the management and human resources implications of the conceptualization of creative personality as an implicit construct.


2020 ◽  
Vol 43 ◽  
Author(s):  
John Corbit ◽  
Chris Moore

Abstract The integration of first-, second-, and third-personal information within joint intentional collaboration provides the foundation for broad-based second-personal morality. We offer two additions to this framework: a description of the developmental process through which second-personal competence emerges from early triadic interactions, and empirical evidence that collaboration with a concrete goal may provide an essential focal point for this integrative process.


Author(s):  
N.S. Allen ◽  
R.D. Allen

Various methods of video-enhanced microscopy combine TV cameras with light microscopes creating images with improved resolution, contrast and visibility of fine detail, which can be recorded rapidly and relatively inexpensively. The AVEC (Allen Video-enhanced Contrast) method avoids polarizing rectifiers, since the microscope is operated at retardations of λ/9- λ/4, where no anomaly is seen in the Airy diffraction pattern. The iris diaphram is opened fully to match the numerical aperture of the condenser to that of the objective. Under these conditions, no image can be realized either by eye or photographically. Yet the image becomes visible using the Hamamatsu C-1000-01 binary camera, if the camera control unit is equipped with variable gain control and an offset knob (which sets a clamp voltage of a D.C. restoration circuit). The theoretical basis for these improvements has been described.


1993 ◽  
Vol 2 (3) ◽  
pp. 52-55 ◽  
Author(s):  
Michael Collins ◽  
Robert McDonald ◽  
Robert Stanley ◽  
Timothy Donovan ◽  
C. Frank Bonebrake

This report describes an unusual and persistent dysphonia in two young women who had taken a therapeutic regimen of isotretinoin for intractable acne. We report perceptual and instrumental data for their dysphonia, and pose a theoretical basis for the relationship of dysphonia to this drug. We also provide recommendations for reducing the risk of acquiring a dysphonia during the course of treatment with isotretinoin.


Author(s):  
Nkiruka Arene ◽  
Argye E. Hillis

Abstract The syndrome of unilateral neglect, typified by a lateralized attention bias and neglect of contralateral space, is an important cause of morbidity and disability after a stroke. In this review, we discuss the challenges that face researchers attempting to elucidate the mechanisms and effectiveness of rehabilitation treatments. The neglect syndrome is a heterogeneous disorder, and it is not clear which of its symptoms cause ongoing disability. We review current methods of neglect assessment and propose logical approaches to selecting treatments, while acknowledging that further study is still needed before some of these approaches can be translated into routine clinical use. We conclude with systems-level suggestions for hypothesis development that would hopefully form a sound theoretical basis for future approaches to the assessment and treatment of neglect.


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