Anemia Management and QOL and Frailty in CKD

Author(s):  
Mariko Miyazaki
Keyword(s):  
2007 ◽  
Vol 27 (2_suppl) ◽  
pp. 205-209 ◽  
Author(s):  
Elvia García–López ◽  
Juan J. Carrero ◽  
Mohamed E. Suliman ◽  
Bengt Lindholm ◽  
Peter Stenvinkel

Patients on peritoneal dialysis (PD) are at high cardiovascular risk. Although some risk factors are unmodifiable (for example, age, sex, genetics), others are exacerbated in the unfriendly uremic milieu (inflammation, oxidative stress, mineral disturbances) or contribute per se to kidney disease and cardiovascular progression (diabetes mellitus, hypertension). Moreover, several factors associated with PD therapy may both increase (by altered lipid profile, hyperinsulinemia, and formation of advanced glycation end-products) and decrease (by better blood pressure control and anemia management) cardiovascular risk. The present review discusses recent findings and therapy trends in cardiovascular research on the PD population, with emphasis on the roles of inflammation, insulin resistance, homocysteinemia, dyslipidemia, vascular calcification, and genetics/epigenetics.


Anemia ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Geoffrey Teehan ◽  
Robert L. Benz

Background. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). The optimal hemoglobin, in non-End Stage Renal Disease CKD, is controversial.Methods. We review three recent randomized trials in anemia in CKD: CHOIR, CREATE, and TREAT.Results. CHOIR (N=1432) was terminated early with more frequent death and cardiovascular outcomes in the higher Hb group (HR 1.34: 95% C.I. 1.03–1.74,P=.03). CREATE (N=603) showed no difference in primary cardiovascular endpoints. Stroke was more common in the higher Hb group (HR 1.92; 95% C.I. 1.38–2.68;P<.001) in TREAT (N=4038).Conclusions. There is no benefit to an Hb outside the 10–12 g/dL range in this population. To avoid transfusions and improve Quality of Life, ESAs should be used cautiously, especially in patients with Diabetes, CKD, risk factors for stroke, and ESA resistance.


2012 ◽  
Vol 26 (5) ◽  
pp. 782-791 ◽  
Author(s):  
Miklos Z. Molnar ◽  
Csaba P. Kovesdy ◽  
Laszlo Rosivall ◽  
Suphamai Bunnapradist ◽  
Junichi Hoshino ◽  
...  

2005 ◽  
Vol 18 (5-6) ◽  
pp. 826-834 ◽  
Author(s):  
Adam E. Gaweda ◽  
Mehmet K. Muezzinoglu ◽  
George R. Aronoff ◽  
Alfred A. Jacobs ◽  
Jacek M. Zurada ◽  
...  

PLoS ONE ◽  
2018 ◽  
Vol 13 (9) ◽  
pp. e0203767 ◽  
Author(s):  
James B. Wetmore ◽  
Suying Li ◽  
Heng Yan ◽  
Hairong Xu ◽  
Yi Peng ◽  
...  

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i462-i462
Author(s):  
Charles Chazot ◽  
Bernard Canaud ◽  
Claudio Ferrari ◽  
Marzio Alunni ◽  
Stefano Stuard

Author(s):  
Arthur Tsai ◽  
Jeffrey S. Berns
Keyword(s):  

2013 ◽  
Vol 61 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Emad E. Ghobrial ◽  
Khaled M. Salama ◽  
Maha F. Shiba ◽  
Naglaa H. El Shafae

Sign in / Sign up

Export Citation Format

Share Document