Deformation-Compensated Averaging for Deep-Tissue LED and Laser Diode-Based Photoacoustic Imaging Integrated with Handheld Echo Ultrasound

2020 ◽  
pp. 47-78 ◽  
Author(s):  
Michael Jaeger ◽  
Hans-Martin Schwab ◽  
Yamen Almallouhi ◽  
Celine Canal ◽  
Maike Song ◽  
...  
Keyword(s):  
Laser Diode ◽  
Photoacoustic Imaging ◽  
Deep Tissue

scholarly journals Recent Advances in Photoacoustic Imaging for Deep-Tissue Biomedical Applications

Theranostics ◽  
2016 ◽  
Vol 6 (13) ◽  
pp. 2394-2413 ◽  
Author(s):  
Sheng Wang ◽  
Jing Lin ◽  
Tianfu Wang ◽  
Xiaoyuan Chen ◽  
Peng Huang
Keyword(s):  
Biomedical Applications ◽  
Photoacoustic Imaging ◽  
Deep Tissue ◽  
Recent Advances

scholarly journals Photoacoustic reporter genes for noninvasive molecular imaging and theranostics

2020 ◽  
Vol 13 (03) ◽  
pp. 2030005
Author(s):  
Zhao Lei ◽  
Yun Zeng ◽  
Xiaofen Zhang ◽  
Xiaoyong Wang ◽  
Gang Liu
Keyword(s):  
Molecular Imaging ◽  
Fluorescent Proteins ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Reporter Genes ◽  
Biological Processes ◽  
Deep Tissue ◽  
Potential Applications ◽  
Improved Performance

Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and spatial resolution in deep tissue. Among the various probes developed for PAI, genetically encoded reporters attracted increasing attention of researchers, which provide improved performance by acquiring images of a PAI reporter gene’s expression driven by disease-specific enhancers/promoters. Here, we present a brief overview of recent studies about the existing photoacoustic reporter genes (RGs) for noninvasive molecular imaging, such as the pigment enzyme reporters, fluorescent proteins and chromoproteins, photoswitchable proteins, including their properties and potential applications in theranostics. Furthermore, the challenges that PAI RGs face when applied to the clinical studies are also examined.

Acceptor Engineering of Small Molecule Fluorophores for NIR-II Fluorescent and NIR-I Photoacoustic Imaging

2021 ◽  
Author(s):  
Yaxi Li ◽  
Hongli Zhou ◽  
Renzhe Bi ◽  
Xiuting Li ◽  
Menglei Zha ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Small Molecule ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Infrared Window

Fluorescence imaging in the second near-infrared window (NIR-II) has been an emerging technique in diverse in vivo applications with high sensitivity/resolution and deep tissue penetration. To date, the designing principle...

Enabling both time-domain and frequency-domain photoacoustic imaging by a fingertip laser diode system

2019 ◽  
Vol 44 (8) ◽  
pp. 1988 ◽  
Author(s):  
Hongtao Zhong ◽  
Jiayao Zhang ◽  
Tingyang Duan ◽  
Hengrong Lan ◽  
Meng Zhou ◽  
...  
Keyword(s):  
Frequency Domain ◽  
Laser Diode ◽  
Time Domain ◽  
Photoacoustic Imaging ◽  
Diode System

scholarly journals Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation

2017 ◽  
Vol 10 (04) ◽  
pp. 1730003 ◽  
Author(s):  
Qingkai Yao ◽  
Yu Ding ◽  
Guodong Liu ◽  
Lvming Zeng
Keyword(s):  
Laser Diode ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Light Emitting Diode ◽  
Imaging Modality ◽  
Low Cost ◽  
Laser System ◽  
Great Promise ◽  
Light Emitting ◽  
Wide Range

Photoacoustic imaging, an emerging biomedical imaging modality, holds great promise for preclinical and clinical researches. It combines the high optical contrast and high ultrasound resolution by converting laser excitation into ultrasonic emission. In order to generate photoacoustic signal efficiently, bulky Q-switched solid-state laser systems are most commonly used as excitation sources and hence limit its commercialization. As an alternative, the miniaturized semiconductor laser system has the advantages of being inexpensive, compact, and robust, which makes a significant effect on production-forming design. It is also desirable to obtain a wavelength in a wide range from visible to near-infrared spectrum for multispectral applications. Focussing on practical aspect, this paper reviews the state-of-the-art developments of low-cost photoacoustic system with laser diode and light-emitting diode excitation source and highlights a few representative installations in the past decade.

scholarly journals Deep Tissue Photoacoustic Imaging Using a Miniaturized 2-D Capacitive Micromachined Ultrasonic Transducer Array

2012 ◽  
Vol 59 (5) ◽  
pp. 1199-1204 ◽  
Author(s):  
S. Kothapalli ◽  
Te-Jen Ma ◽  
S. Vaithilingam ◽  
O. Oralkan ◽  
B. T. Khuri-Yakub ◽  
...  
Keyword(s):  
Photoacoustic Imaging ◽  
Ultrasonic Transducer ◽  
Deep Tissue ◽  
Transducer Array ◽  
Capacitive Micromachined Ultrasonic Transducer
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