Development of Micellized Antimicrobial Thiosulfinate: A Contemporary Way of Drug Stability Enhancement

2020 ◽  
pp. 83-89
Author(s):  
Souptik Bhattacharya ◽  
Deepanjali Gupta ◽  
Dwaipayan Sen ◽  
Chiranjib Bhattacharjee
Keyword(s):  
Drug Stability ◽  
Stability Enhancement

Small Molecular Gemcitabine Prodrugs for Cancer Therapy

2020 ◽  
Vol 27 (33) ◽  
pp. 5562-5582 ◽  
Author(s):  
He Miao ◽  
Xuehong Chen ◽  
Yepeng Luan
Keyword(s):  
Drug Resistance ◽  
Side Effects ◽  
Anticancer Drug ◽  
Drug Stability ◽  
Effective Means ◽  
Active Form ◽  
Deoxycytidine Kinase ◽  
High Efficacy ◽  
Pyrimidine Nucleoside ◽  
Design And Synthesis

Gemcitabine as a pyrimidine nucleoside analog anticancer drug has high efficacy for a broad spectrum of solid tumors. Gemcitabine is activated within tumor cells by sequential phosphorylation carried out by deoxycytidine kinase to mono-, di-, and triphosphate nucleotides with the last one as the active form. But the instability, drug resistance and toxicity severely limited its utilization in clinics. In the field of medicinal chemistry, prodrugs have proven to be a very effective means for elevating drug stability and decrease undesirable side effects including the nucleoside anticancer drug such as gemcitabine. Many works have been accomplished in design and synthesis of gemcitabine prodrugs, majority of which were summarized in this review.

scholarly journals Magnetic Nanostructures as Emerging Therapeutic Tools to Boost Anti-Tumour Immunity

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2735
Author(s):  
Stefano Persano ◽  
Pradip Das ◽  
Teresa Pellegrino
Keyword(s):  
Cancer Immunotherapy ◽  
Low Cost ◽  
Drug Stability ◽  
Adoptive Cell Therapy ◽  
Magnetic Nanostructures ◽  
Immune Checkpoint Blockade ◽  
Therapeutic Vaccines ◽  
Durable Response ◽  
Tumour Immunity ◽  
Therapeutic Modalities

Cancer immunotherapy has shown remarkable results in various cancer types through a range of immunotherapeutic approaches, including chimeric antigen receptor-T cell (CAR-T) therapy, immune checkpoint blockade (ICB), and therapeutic vaccines. Despite the enormous potential of cancer immunotherapy, its application in various clinical settings has been limited by immune evasion and immune suppressive mechanisms occurring locally or systemically, low durable response rates, and severe side effects. In the last decades, the rapid advancement of nanotechnology has been aiming at the development of novel synthetic nanocarriers enabling precise and enhanced delivery of immunotherapeutics, while improving drug stability and effectiveness. Magnetic nanostructured formulations are particularly intriguing because of their easy surface functionalization, low cost, and robust manufacturing procedures, together with their suitability for the implementation of magnetically-guided and heat-based therapeutic strategies. Here, we summarize and discuss the unique features of magnetic-based nanostructures, which can be opportunely designed to potentiate classic immunotherapies, such as therapeutic vaccines, ICB, adoptive cell therapy (ACT), and in situ vaccination. Finally, we focus on how multifunctional magnetic delivery systems can facilitate the anti-tumour therapies relying on multiple immunotherapies and/or other therapeutic modalities. Combinatorial magnetic-based therapies are indeed offering the possibility to overcome current challenges in cancer immunotherapy.

scholarly journals Dual Two-Level Voltage Source Inverter Virtual Inertia Emulation: A Comparative Study

Energies ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1160
Author(s):  
Mohammad Ali Dashtaki ◽  
Hamed Nafisi ◽  
Amir Khorsandi ◽  
Mojgan Hojabri ◽  
Edris Pouresmaeil
Keyword(s):  
Harmonic Distortion ◽  
Synchronous Generator ◽  
Voltage Source ◽  
Small Signal ◽  
Voltage Source Inverter ◽  
Nonlinear Loads ◽  
Virtual Inertia ◽  
The Stability ◽  
Stability Enhancement ◽  
Oscillation Damping

In this paper, the virtual synchronous generator (VSG) concept is utilized in the controller of the grid-connected dual two-level voltage source inverter (DTL VSI). First, the topology of the VSG and the DTL VSI are presented. Then, the state-space equations of the DTL VSI and the grid-connected two-level voltage source inverter (TL VSI), regarding the presence of the phase-locked loop (PLL) and the VSG, are given. Next, the small-signal modeling of the DTL VSI and the TL VSI is realized. Eventually, the stability enhancement in the DTL VSI compared with the TL VSI is demonstrated. In the TL VSI, large values of virtual inertia could result in oscillations in the power system. However, the ability of the DTL VSI in damping oscillations is deduced. Furthermore, in the presence of nonlinear loads, the potentiality of the DTL VSI in reducing grid current Total Harmonic Distortion (THD) is evaluated. Finally, by using a proper reference current command signal, the abilities of the DTL VSI and the TL VSI in supplying nonlinear loads and providing virtual inertia are assessed simultaneously. The simulation results prove the advantages of the DTL VSI compared with the TL VSI in virtual inertia emulation and oscillation damping, which are realized by small-signal analysis.

Sign in / Sign up

Export Citation Format

Share Document