scholarly journals Fever and Rheumatology

2021 ◽  
pp. 241-261
Author(s):  
Mohamed Cheikh ◽  
Nezar Bahabri

AbstractIn all the patients with rheumatic diseases, fever should prompt an immediate and thorough evaluation. There are different disorders that can cause fever and arthritis. Fever that is thought to be due to active rheumatic disease is seen in over 50% of patients with SLE30. However, it can be also related to or a sequel of an infectious process. There are many infectious diseases with rheumatological manifestations. The aim of this chapter therefore is to address variable relationships of fever with patients with arthritis. Fever of unknown origin will be addressed as some systemic rheumatic disease may present with fever. It is always a dilemma when an established patient with arthritis presents with fever. What should you do? This issue is addressed with a suggested diagnostic approach that guides you in a stepwise manner until you reach to the definitive diagnosis.

2017 ◽  
Vol 59 (3) ◽  
pp. 201
Author(s):  
D. PARDALI (Δ. ΠΑΡΔΑΛΗ) ◽  
K. ADAMAMA-MORAITOU (Κ. ΑΔΑΜΑΜΑ-ΜΩΡΑΪΤΟY) ◽  
T. RALLIS (Τ. ΡΑΛΛΗΣ)

Fever of unknown origin (FUO) refers to a febrile syndrome that does not resolve spontaneously in an adequate period of time for the remission of self-limited infections and definitive diagnosis cannot be established despite considerable diagnostic effort. This definition is an extrapolation from human medicine, since FUO has not been still defined accurately in animals. The spectrum of diseases involved in FUO includes infectious, neoplastic, immune-mediated, miscellaneous and not defined diseases. Clients and clinicians must be aware that FUO may be a diagnostic challenge. The diagnostic plan should always begin with costless and simple tests followed by more invasive and expensive procedures. The initial diagnostic approach of FUO includes a detailed history, a thorough physical examination, a routine laboratory evaluation and radiographical examination of the thorax and abdomen. If diagnosis cannot be achieved, specific non-invasive tests should then be applied. No therapeutic trial should be initiated during evaluation, since it may alleviate clinical symptoms and alter the laboratory results potentially misleading the diagnostic approach. Nevertheless, fever is rarely harmful. In body temperature above 41,0 °C, diagnostic evaluation is postponed and the initiation of an emergency therapy is strongly recommended. If definitive diagnosis is confirmed, the dog is treated accordingly. Therapeutic trial is indicated, if despite the thorough evaluation no diagnosis is established or the owners are unwilling to support the cost of the diagnostic work-up of their dog. Therapy is focused on the administration of antibiotics followed by steroids and finally non-steroid anti-inflammatory drugs.


Author(s):  
Dr Nicholas Price ◽  
Dr John L Klein

Chapter 6 covers infectious diseases and emergencies, including clinical features, history, and examination, the febrile patient with skin lesions or rash, hospital-acquired (nosocomial), infections, classic viral exanthems and mumps, ‘mononucleosis’ syndromes, fungal infections, fever in the returning traveller, fever of unknown origin (FUO), principles and practice of antibiotic use, public health aspects of infectious disease, malaria, meningococcal disease, infections in pregnancy, vascular access device-associated infection, and toxic shock syndrome.


Author(s):  
Annie Antar

This chapter on fever of unknown origin (FUO) begins by clarifying the definition of FUO and continues by listing and describing the major etiologies of FUO, providing guidance on clinical workup and discussing best management practices. Discussion of FUO etiologies emphasizes that most fall under a few categories—rheumatological, infectious, neoplastic, and other. Emergency management of stable, immunocompetent patients with FUO is best when focused on an appropriate diagnostic workup so that a definitive diagnosis can be established and treated with targeted therapy. Antibiotics should not be started in the emergency department for stable, immunocompetent patients with FUO unless the specific etiology is uncovered. This chapter is concise and targeted to the emergency medicine provider who needs to know how best to evaluate and manage the patient with a clinical history consistent with FUO.


2020 ◽  
Vol 33 ◽  
pp. 101425
Author(s):  
Nikolaos Spernovasilis ◽  
Constantinos Tsioutis ◽  
Lamprini Markaki ◽  
Maria Zafeiri ◽  
Stella Soundoulounaki ◽  
...  

2021 ◽  
Vol 28 (04) ◽  
pp. 552-556
Author(s):  
Aysha Mansoor Lodhi ◽  
Wajiha Rizwan ◽  
Mubeen Nazar ◽  
Asma Mushtaq ◽  
Muhammad Sahir Saud ◽  
...  

Objectives: To determine the etiology of Fever of Unknown Origin (FUO) in children. Study Design: Prospective Observational study. Setting: Department of Pediatric Medicine, The Children's Hospital, Lahore. Period: August 2019 to January 2020. Material & Methods: A total of 45 children aged between 01 to 180 months (15 years), having FUO were included. FUO was defined as a temperature of greater than 100.4ºF documented by a health care provider, persisting over a period of three weeks and for which no cause could be identified after at least 8 days of evaluation. All the study information was analyzed by using standard software SPSS 20. The quantitative variables like age and duration of fever before hospital admission were presented as mean and standard deviation. Qualitative variables like sex, antibiotic therapy use before definitive diagnosis and various diagnoses made were presented as frequencies and percentages. Results: The patient’s age range was from 01 to 180 months with mean of 80±45.12 months and male to female ratio was 2.2:1. Definitive diagnosis was made in 37(82.2%) patients. Infections were the predominant cause of FUO (44.4%) followed by malignancy (24.4%). Tuberculosis was the most common infection while Acute Lymphoblastic leukemia dominated the malignancy. Systemic lupus erythematosus was the most commonly diagnosed connective tissue disorder.  There was a significant association between duration of fever and the ultimate diagnosis (p=0.01). Conclusion: Infectious diseases were the most common cause of FUO followed by malignancy, connective tissue disorders and miscellaneous causes.


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