scholarly journals Myocardial ischemia and reperfusion: The role of oxygen radicals in tissue injury

1989 ◽  
Vol 2 (6) ◽  
pp. 761-769 ◽  
Author(s):  
Steven W. Werns ◽  
Benedict R. Lucchesi
Keyword(s):  
Myocardial Ischemia ◽  
Oxygen Radicals ◽  
Tissue Injury ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion

The role of the neutrophil in myocardial ischemia and reperfusion

1996 ◽  
pp. 263-284 ◽  
Author(s):  
N. G. Frangogiannis ◽  
K. A. Youker ◽  
M. L. Entman
Keyword(s):  
Myocardial Ischemia ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion

scholarly journals The Protective Role of Interleukin-33 in Myocardial Ischemia and Reperfusion Is Associated with Decreased HMGB1 Expression and Up-Regulation of the P38 MAPK Signaling Pathway

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0143064 ◽  
Author(s):  
Ma Ruisong ◽  
Hu Xiaorong ◽  
Hu Gangying ◽  
Yi Chunfeng ◽  
Zhang Changjiang ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Mapk Signaling ◽  
Protective Role ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Interleukin 33 ◽  
Hmgb1 Expression

scholarly journals Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin

2009 ◽  
Vol 297 (5) ◽  
pp. H1853-H1859 ◽  
Author(s):  
Marc N. Busche ◽  
Vasile Pavlov ◽  
Kazue Takahashi ◽  
Gregory L. Stahl
Keyword(s):  
Myocardial Ischemia ◽  
Complement Activation ◽  
Tissue Injury ◽  
Left Ventricular ◽  
Mannose Binding Lectin ◽  
Left Ventricular Ejection ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Mannose Binding ◽  
Binding Lectin

Complement activation has been shown to play an important role in the inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R). Several recent studies from our laboratory demonstrated the importance of mannose-binding lectin (MBL) as the initiation pathway for complement activation and the resulting pathological effects following MI/R. However, other studies from the past suggest an important role of the classical pathway and perhaps natural antibodies. In the present study, we used newly generated genetically modified mice that lack secreted IgM (sIgM), MBL-A, and MBL-C (sIgM/MBL null) in a plasma reconstitution mouse model of MI/R. Following 30 min of ischemia and 4 h of reperfusion, left ventricular ejection fractions were significantly higher in sIgM/MBL null mice reconstituted with MBL null or sIgM/MBL null plasma compared with reconstitution with wild-type (WT) plasma or WT mice reconstituted with WT plasma following MI/R. Serum troponin I concentration, myocardial polymorphonuclear leukocyte infiltration, and C3 deposition were dependent on the combined presence of sIgM and MBL. These results demonstrate that MI/R-induced complement activation, inflammation, and subsequent tissue injury require both IgM and MBL. Thus MBL-dependent activation of the lectin pathway may not be completely antibody independent in I/R models.

scholarly journals Reflex responses to myocardial ischemia and reperfusion. Role of prostaglandins.

Circulation ◽  
1989 ◽  
Vol 80 (6) ◽  
pp. 1878-1885 ◽  
Author(s):  
M D Thames ◽  
A J Minisi
Keyword(s):  
Myocardial Ischemia ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Reflex Responses

scholarly journals Role of KATP channels in arrhythmogenesis during regional myocardial ischemia and reperfusion.

1999 ◽  
Vol 19 (2) ◽  
pp. 144-152
Author(s):  
Toshihisa Miyazaki ◽  
Mika Asanagi ◽  
Shinji Ito ◽  
Shunsuke Takagi ◽  
Yoshiko Furukawa ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Katp Channels ◽  
Ischemia And Reperfusion ◽  
Myocardial Ischemia And Reperfusion ◽  
Regional Myocardial Ischemia
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