Microsomal redox systems in brown adipose tissue: high lipid peroxidation, low cholesterol biosynthesis and no detectable cytochrome P-450

1990 ◽  
Vol 92 (2) ◽  
Author(s):  
B. Seshadri Sekhar ◽  
C.K. Ramakrishna Kurup ◽  
T. Ramasarma
Keyword(s):  
Lipid Peroxidation ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cholesterol Biosynthesis ◽  
Redox Systems ◽  
High Lipid ◽  
Brown Adipose ◽  
Cytochrome P 450 ◽  
Low Cholesterol ◽  
High Lipid Peroxidation

scholarly journals Seasonal and photoperiodic effects on lipid droplet size and lipid peroxidation in the brown adipose tissue of bank voles (Myodes glareolus)

2012 ◽  
Vol 57 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Elżbieta Bonda-Ostaszewska ◽  
Tadeusz Włostowski ◽  
Alicja Krasowska ◽  
Paweł Kozłowski
Keyword(s):  
Lipid Peroxidation ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Droplet Size ◽  
Lipid Droplet ◽  
Myodes Glareolus ◽  
Bank Voles ◽  
Brown Adipose ◽  
Lipid Droplet Size

scholarly journals Effect of cold acclimation on GSH, antioxidant enzymes and lipid peroxidation in brown adipose tissue

1991 ◽  
Vol 277 (1) ◽  
pp. 289-292 ◽  
Author(s):  
G Barja de Quiroga ◽  
M López-Torres ◽  
R Pérez-Campo ◽  
M Abelenda ◽  
M Paz Nava ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Acclimation ◽  
Antioxidant Enzyme Activities ◽  
Antioxidant Defences ◽  
Glutathione Peroxidases ◽  
Brown Adipose ◽  
Order Of Magnitude ◽  
Higher Sensitivity

Cold acclimation increased the activities of superoxide dismutase, catalase, total and selenium (Se)-dependent glutathione peroxidases (GPx) and glutathione reductase by 2-4-fold in the brown adipose tissue (BAT) of cold-acclimated rats. Nevertheless, when expressed per unit protein, the antioxidant enzyme activities were unaltered. Sensitivity to lipid peroxidation and GSH levels both increased by one order of magnitude in the cold on a per weight basis and were still 3-5 times greater in the cold when expressed per mg of protein. We suggest that activation of BAT leads to a large increase in the potential for lipid peroxidation and that the tissue responds to this challenge by increasing practically all of its antioxidant defences. Nevertheless, GSH, and possibly GPx activity, seem to be the principal defences involved in adaptation of the tissue to a higher sensitivity to peroxidative damage after activation.

Effect of cold on lipid peroxidation in the brown adipose tissue and liver of rats

2008 ◽  
Vol 33 (3) ◽  
pp. 180-184 ◽  
Author(s):  
Tadeusz Włostowski ◽  
Elżbieta Bonda ◽  
Alicja Krasowska
Keyword(s):  
Lipid Peroxidation ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose

The effects of meal-feeding and the diurnal cycle on lipogenesis in brown adipose tissue of rats

1987 ◽  
Vol 7 (11) ◽  
pp. 871-879 ◽  
Author(s):  
Mary P. Thompson ◽  
Murray R. Grigor
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
High Lipid ◽  
Brown Adipose ◽  
Significant Difference ◽  
Feeding Regimes ◽  
Plasma Insulin Levels ◽  
Meal Feeding ◽  
High Lipid Diet

A significant diurnal variation in the rates of lipogenesis in vivo in brown adipose tissue occurred in both virgin and lactating rats. On a meal-feeding regime of either a chow, high-sucrose, or high-lipid diet, there was a very large increase in BAT lipogenesis following the meal. The rates observed after the sucrose meal are the highest so far reported. There was no significant difference in BAT lipogenesis between lactating and virgin rats, contrary to previous reports by others. The pattern of stimulation of BAT lipogenesis by these feeding regimes was different from that for white adipose tissue and liver and was not correlated with plasma insulin levels.

scholarly journals The influence of vitamin e supplementation on the oxidative status of rat interscapular brown adipose tissue

2010 ◽  
Vol 62 (4) ◽  
pp. 993-997
Author(s):  
S.F. Djurasevic ◽  
Jelena Djordjevic ◽  
N. Jasnic ◽  
Iva Lakic ◽  
P. Vujovic ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Adipose Tissue ◽  
Vitamin E ◽  
Brown Adipose Tissue ◽  
Oxidative Status ◽  
Activity Levels ◽  
Interscapular Brown Adipose Tissue ◽  
Brown Adipose ◽  
Tocopheryl Succinate ◽  
Vitamin E Supplementation

We tested whether the additional intake of vitamin E in the form of ?-tocopheryl-succinate would improve the interscapular brown adipose tissue (IBAT) antioxidative protection. Thus, we studied the tissue oxidative status in rats supplemented by two doses of vitamin E over a four-week period. Our results confirmed that vitamin E supplementation decreased the IBAT lipid peroxidation level, SOD and catalase activity levels, the hydrogen peroxide concentration and spared its vitamin C content.

Functional characterization of human brown adipose tissue metabolism

2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Functional Characterization ◽  
Human Infants ◽  
Positron Emission ◽  
Brown Adipose ◽  
Treatment Of Obesity ◽  
And Function

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

Brown adipose tissue (BAT) can normalize hyperglycemia and hypertriglyceridemia in mice

2011 ◽  
Vol 6 (S 01) ◽  
Author(s):  
M Merkel ◽  
A Bartelt ◽  
K Brügelmann ◽  
J Heeren
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose

The influence of thyroid dysfunction on the activity of brown adipose tissue in mice detected by [18F]FDG PET/MR

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
K Krause ◽  
M Kranz ◽  
V Zeisig ◽  
N Klöting ◽  
K Steinhoff ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Thyroid Dysfunction ◽  
Brown Adipose ◽  
18F Fdg

Nesfatin-1 employs the central melanocortin pathway to stimulate non-shivering thermogenesis in brown adipose tissue (BAT)

2017 ◽  
Vol 12 (S 01) ◽  
pp. S1-S84
Author(s):  
L Levata ◽  
R Dore ◽  
O Jöhren ◽  
H Lehnert ◽  
C Schulz
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Shivering Thermogenesis
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