Use of total inspiratory pressure-volume curves for determination of appropriate positive end-expiratory pressure in newborns with hyaline membrane disease

1987 ◽  
Vol 13 (5) ◽  
pp. 332-336 ◽  
Author(s):  
J. C. Mathe ◽  
A. Clement ◽  
J. Y. Chevalier ◽  
C. Gaultier ◽  
J. Costil
PEDIATRICS ◽  
1975 ◽  
Vol 56 (2) ◽  
pp. 341-342
Author(s):  
Dilip M. Purohit

There have been quite a few case reports in the last few years about pneumopericardium in the neonatal period, including the one by Yeh et al. which appeared in the October issue of Pediatrics,1 where they also reviewed the previous reports. The majority of the infants have had hyaline membrane disease and intermittent positive pressure ventilation (IPPV) with a bag or a respirator. Some have had IPPV with positive end-expiratory pressure (PEEP). Information regarding ventilatory therapy, viz., the type of respirator used, rate, inspiratory pressure, and inspiratory/ expiratory ratio is either not mentioned or very scanty.


1980 ◽  
Vol 69 (5) ◽  
pp. 603-606 ◽  
Author(s):  
R. B. COTTON ◽  
DANIEL P. LINDSTROM ◽  
KEITH S. KANAREK ◽  
HAKAN SUNDELL ◽  
MILDRED T. STAHLMAN

PEDIATRICS ◽  
1973 ◽  
Vol 51 (4) ◽  
pp. 629-640
Author(s):  
Niloufer Cumarasamy ◽  
Rosmarie Nüssli ◽  
Dieter Vischer ◽  
Peter H. Dangel ◽  
Gabriel V. Duc

During the years 1969, 1970, and 1971, 120 infants with hyaline membrane disease were studied, of whom 71 were treated with artificial ventilation. Among other changes in 1971, positive end-expiratory pressure was applied during mechanical ventilation and continuous positive airway pressure maintained during the weaning period. The survival rate of the ventilated babies increased from 23% in the preceding two years to 70% in 1971. As this study is not a controlled trial, the observed increase in survival cannot be ascribed to the application of increased airway pressure alone. The data presented, though necessarily inconclusive, may be useful for continuing comparisons with other pediatric centers.


PEDIATRICS ◽  
1981 ◽  
Vol 67 (4) ◽  
pp. 474-481
Author(s):  
A. R. Stewart ◽  
N. N. Finer ◽  
K. L. Peters

Twenty neonates requiring mechanical ventilation for respiratory failure, including 13 with hyaline membrane disease, were studied to assess the effects of alterations in ventilator settings on mean airway pressure (MAP), blood gases, and intracranial pressure (ICP). The study involved random alterations in peak inspiratory pressure (PIP), positive end-expiratory pressure (PEEP), and inspiratory/expiratory ratio while MAP, Pao2, ICP, and end-tidal Pco2 were continuously monitored. The results showed a significant relationship between MAP and Pao2 that was expressed as the change in Pao2 per millimeter of mercury change in MAP (ΔPa02/ΔMAP) with a mean ΔPao2/ΔMAP of 4.92. The ΔPao2/ΔMAP was highest for changes in PEEP (6.08), followed by PIP (5.07), and inspiratory/expiratory ratio (1.9). There was a significant relationship between alterations in PEEP and PIP vs Paco2 and pH. Increases in PEEP and decreases in PIP resulted in an elevated Paco2 and a lowered pH, and decreases in PEEP and increases in PIP resulted in a decreased Paco2 and an elevated pH. There was no significant relationship between MAP and ICP, but there was a significant association between ΔICP and ΔPaco2 during alterations in PIP (r = .64, P <.001). Increases in PEEP will lead to the greatest increase in Pao2 per change in MAP, followed by increases in PIP and inspiratory /expiratory ratio using a pressure-limited ventilator.


2017 ◽  
Vol 38 (3-4) ◽  
pp. 47
Author(s):  
Lasmida Nazir Nuriman ◽  
Dadang Sjarif Hidajat

There have been controversies over the eiTect of hypertension in pregnancy on the incidence of type I neonatal respiratory distress syndrome or hyaline membrane disease (HMD). We investigated the relationship between the incidence of HMD and maternal hypertension during pregnancy in 91 infants at 34 weeks gestation or less. This retrospective cross sectional study included all live born babies between May 1, 1994 and April 30, 1995 at Dr. Hasan Sadikin General Hospital, Bandung. Maternal hypertension during pregnancy was diagnosed in 38 mothers of91 infants studied. The incidence of HMD (5%) in the maternal hypertension during pregnancy group was significantly lower than the 62% in the normotensive group (p<0.01). There was a negative correlation between the occurence of HMD and hypertension during pregnancy. We conclude that the risk of developing HMD in infants born to hypertensive mothers is significantly lower than those born to normotensive mothers.


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