The generation of transplasmic Drosophila simulans by cytoplasmic injection Effects of segregation and selection on the perpetuation of mitochondrial DNA heteroplasmy

1989 ◽  
Vol 220 (1) ◽  
pp. 127-132 ◽  
Author(s):  
Eric de Stordeur ◽  
Michel Solignac ◽  
Monique Monnerot ◽  
Jean-Claude Mounolou
Keyword(s):  
Mitochondrial Dna ◽  
Drosophila Simulans ◽  
Mitochondrial Dna Heteroplasmy ◽  
Cytoplasmic Injection

scholarly journals Mitochondrial DNA heteroplasmy maintained in natural populations of Drosophila simulans in Réunion

1991 ◽  
Vol 57 (2) ◽  
pp. 123-126 ◽  
Author(s):  
Etsuko T. Matsuura ◽  
Haruyo Fukuda ◽  
Sadao I. Chigusa
Keyword(s):  
Mitochondrial Dna ◽  
Natural Populations ◽  
Drosophila Simulans ◽  
Restriction Pattern ◽  
Isofemale Lines ◽  
Local Populations ◽  
Mtdna Variation ◽  
Mitochondrial Dna Heteroplasmy

SummaryMitochondrial DNA (mtDNA) variation in Drosophila simulans was studied to determine whether the cytoplasmic state of mtDNA heteroplasmy persists in natural populations in Réunion. For this purpose, 172 isofemale lines, newly collected from two local populations, were examined, among which three types of mtDNA (siII, siIII and siIII′) were found, based on the Hpa II restriction pattern. Ten of the lines were heteroplasmic for a combination of siII and siIII, as determined by autoradiography. The same type of heteroplasmy had been noted in one of the two local populations 8 years before (Satta et al. 1988). The present results suggest that the heteroplasmic state occurs recurrently in natural populations of D. simulans in Réunion.

scholarly journals Mitochondrial DNA Heteroplasmy as an Informational Reservoir Dynamically Linked to Metabolic and Immunological Processes Associated with COVID-19 Neurological Disorders

2021 ◽  
Author(s):  
George B. Stefano ◽  
Richard M. Kream
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Function ◽  
Neurological Disorders ◽  
Nuclear Dna ◽  
Mitochondrial Dynamics ◽  
Cell Types ◽  
Tissue Specific ◽  
Copy Numbers ◽  
The Central Nervous System ◽  
Mitochondrial Dna Heteroplasmy

AbstractMitochondrial DNA (mtDNA) heteroplasmy is the dynamically determined co-expression of wild type (WT) inherited polymorphisms and collective time-dependent somatic mutations within individual mtDNA genomes. The temporal expression and distribution of cell-specific and tissue-specific mtDNA heteroplasmy in healthy individuals may be functionally associated with intracellular mitochondrial signaling pathways and nuclear DNA gene expression. The maintenance of endogenously regulated tissue-specific copy numbers of heteroplasmic mtDNA may represent a sensitive biomarker of homeostasis of mitochondrial dynamics, metabolic integrity, and immune competence. Myeloid cells, monocytes, macrophages, and antigen-presenting dendritic cells undergo programmed changes in mitochondrial metabolism according to innate and adaptive immunological processes. In the central nervous system (CNS), the polarization of activated microglial cells is dependent on strategically programmed changes in mitochondrial function. Therefore, variations in heteroplasmic mtDNA copy numbers may have functional consequences in metabolically competent mitochondria in innate and adaptive immune processes involving the CNS. Recently, altered mitochondrial function has been demonstrated in the progression of coronavirus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Accordingly, our review is organized to present convergent lines of empirical evidence that potentially link expression of mtDNA heteroplasmy by functionally interactive CNS cell types to the extent and severity of acute and chronic post-COVID-19 neurological disorders.

scholarly journals Reduced Variation in Drosophila simulans Mitochondrial DNA

Genetics ◽  
1996 ◽  
Vol 144 (4) ◽  
pp. 1519-1528
Author(s):  
J William O Ballad ◽  
Joy Hatzidakis ◽  
Timothy L Karr ◽  
Martin Kreitman
Keyword(s):  
Mitochondrial Dna ◽  
Mitochondrial Genome ◽  
Evolutionary Dynamics ◽  
Selective Sweep ◽  
Mitochondrial Gene ◽  
Drosophila Simulans ◽  
Dramatic Reduction ◽  
Nucleotide Variability ◽  
Pooled Samples ◽  
Mitochondrial Gene Mutation

We investigated the evolutionary dynamics of infection of a Drosophila simulans population by a maternally inherited insect bacterial parasite, Wolbachia, by analyzing nucleotide variability in three regions of the mitochondrial genome in four infected and 35 uninfected lines. Mitochondrial variability is significantly reduced compared to a noncoding region of a nuclear-encoded gene in both uninfected and pooled samples of flies, indicating a sweep of genetic variation. The selective sweep of mitochondrial DNA may have been generated by the fixation of an advantageous mitochondrial gene mutation in the mitochondrial genome. Alternatively, the dramatic reduction in mitochondrial diversity may be related to Wolbachia.

scholarly journals Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmy

2005 ◽  
Vol 37 (8) ◽  
pp. 873-877 ◽  
Author(s):  
Gábor Zsurka ◽  
Yevgenia Kraytsberg ◽  
Tatiana Kudina ◽  
Cornelia Kornblum ◽  
Christian E Elger ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dna ◽  
Mitochondrial Dna Heteroplasmy

Results of a collaborative study of the EDNAP group regarding mitochondrial DNA heteroplasmy and segregation in hair shafts

2004 ◽  
Vol 140 (1) ◽  
pp. 1-11 ◽  
Author(s):  
G Tully ◽  
S.M Barritt ◽  
K Bender ◽  
E Brignon ◽  
C Capelli ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Collaborative Study ◽  
Mitochondrial Dna Heteroplasmy ◽  
Hair Shafts
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