Whole-body retention of mercury and selenium and histopathological and morphological studies of kidneys and liver of rats exposed repeatedly to mercuric chloride and sodium selenite

1978 ◽  
Vol 40 (3) ◽  
pp. 189-199 ◽  
Author(s):  
Jadwiga Chmielnicka ◽  
Zygmunt Hajdukiewicz ◽  
Elżbieta Komsta-Szumska ◽  
Stanisław Łukaszek
Keyword(s):  
Mercuric Chloride ◽  
Sodium Selenite ◽  
Whole Body ◽  
Morphological Studies ◽  
Body Retention

Effect of Four Thiol-Containing Chelators on Disposition of Orally Administered Mercuric Chloride

1991 ◽  
Vol 10 (6) ◽  
pp. 423-430 ◽  
Author(s):  
J.B. Nielsen ◽  
O. Andersen
Keyword(s):  
Acute Toxicity ◽  
Oral Administration ◽  
Mercuric Chloride ◽  
Inorganic Mercury ◽  
Parenteral Administration ◽  
Whole Body ◽  
Drug Of Choice ◽  
Body Retention ◽  
Route Of Exposure ◽  
The Brain

Acute toxicity and the disposition of inorganic mercury depends on the route of exposure. Most previous studies on effect of chelators on inorganic mercury toxicity and toxicokinetics employed parenteral administration of both metal and chelator. However, the most prominent routes for human inorganic mercury exposure are the oral or pulmonary. BAL was previously considered the drug of choice in human intoxications with most heavy metals. This recommandation has been questioned during recent years due to the advent of the less toxic hydrophilic BAL analogues DMSA and DMPS. The present study, using oral administration of HgCl2 labelled with 203Hg, demonstrates that DMPS is superior to the other chelators in preventing mortality. Moreover, both DMSA and DMPS are superior to BAL and NAPA in alleviating acute toxicity and in preventing the undesirable distribution of orally administered mercury, especially to the brain. Further, oral administration of these chelators were more efficient than parenteral administration in reducing whole-body retention and organ deposition of orally administered mercuric chloride, most likely due to the prevention of intestinal uptake of mercury.

Radioimmunszintigraphie mit SPECT: Methodik, Probleme und klinische Erfahrungen

1987 ◽  
Vol 26 (05) ◽  
pp. 202-205 ◽  
Author(s):  
J. Fass ◽  
S. Truong ◽  
U. Büll ◽  
V. Schumpelick ◽  
R. Bares
Keyword(s):  
Clinical Practice ◽  
The Other ◽  
Whole Body ◽  
Blood Clearance ◽  
Planar Scintigraphy ◽  
Gastrointestinal Carcinomas ◽  
Body Regions ◽  
Other Hand ◽  
Body Retention ◽  
Klinische Erfahrungen

Radioimmunoscintigraphy (RIS) with 111ln- and 131 I-labelled monoclonal anti bodies (MAbs) against CEA and/or CA 19-9 was performed in 83 patients with various gastrointestinal carcinomas. A total of 276 body regions could be examined. The results of planar scintigraphy and SPECT were compared intraindividually. Using 111 In-labelled MAbs the sensitivity of RIS was significantly improved by SPECT (88.9 vs. 52.4% with planar scintigraphy, p <0.01). For131 l-labelled MAbs the effect was smaller (83.9 vs. 65.6% with planar scintigraphy, n.s.). This finding can be explained by different kinetics and biodistribution of the used MAb preparations.111 In-labelled MAbs with long whole-body retention and rapid blood clearance reveal ideal qualities for SPECT; on the other hand, the short whole-body retention of131 l-labelled MAbs leads to small count rates and therefore long counting times that make delayed SPECT unsuitable in clinical practice

Effect of Sodium Selenite on Metallothionem Induction by the Treatment of Mercuric Chloride to Rats

1989 ◽  
Vol 1 (2) ◽  
pp. 236
Author(s):  
Yo Hwan Yang ◽  
Hyo Min Lee ◽  
Dong Chun Shin ◽  
Yong Chung
Keyword(s):  
Mercuric Chloride ◽  
Sodium Selenite

scholarly journals Improved zinc and iron absorption from breakfast meals containing malted oats with reduced phytate content

1996 ◽  
Vol 76 (5) ◽  
pp. 677-688 ◽  
Author(s):  
Marie Larsson ◽  
Lena Rossander-Hulthén ◽  
Brittmarie Sandström ◽  
Ann-Sofie Sandberg
Keyword(s):  
Iron Absorption ◽  
Human Subjects ◽  
Vulnerable Groups ◽  
Whole Body ◽  
Absolute Amount ◽  
Average Increase ◽  
Mineral Deficiency ◽  
Breakfast Meal ◽  
Body Retention ◽  
Phytate Content

The absorption of Zn or Fe from breakfast meals containing oat porridge prepared from malted and soaked oats and a control porridge made from untreated oats was measured in human subjects. The effect on Zn and Fe absorption of reducing the phytate content of oat-porridge meals was examined in each subject by extrinsic labelling of porridge with 65Zn and of bread rolls with 55Fe and 59Fe, and measuring whole-body retention and the erythrocyte uptake of isotopes. Each experiment comprised nine to ten subjects. The absorption of Zn from malted-oat porridge with a phytate (inositol hexaphosphate) content of 107 μmol was 18·3%, and significantly higher (P < 0·05) than from the control porridge containing 432 μmol phytate (11·8%). Fe absorption from the meal containing malted-oat porridge with 107 μmol phytate (Expt 2) was also significantly improved (P < 0·05) compared with that from the meal containing control porridge with 437 μmol phytate. The average increase in Fe absorption was 47%, or from 4·4 to 6·0%. In the breakfast meal containing malted porridge with 198 μmol phytate (Expt 3) the increase in Fe absorption was not significantly improved. Even though the phytate content was reduced to a greater extent in Expt 3 than Expt 2, the average increase in Fe absorption in Expt 3 was only 25% more than that from the meal containing control porridge (with 599 μmol phytate), depending on the higher absolute amount of phytate. In conclusion, an improvement in Zn and Fe absorption from oat products can be achieved by practising malting and soaking in the processing of oats. This may be of importance in the prevention of mineral deficiency in vulnerable groups.

Gastrointestinal iron and cobalt absorption and iron status in young rats and guinea pigs

1995 ◽  
Vol 14 (12) ◽  
pp. 949-954 ◽  
Author(s):  
Gpl Naylor ◽  
JD Harrison
Keyword(s):  
Guinea Pig ◽  
Guinea Pigs ◽  
Iron Status ◽  
Age Groups ◽  
Gastrointestinal Absorption ◽  
Whole Body ◽  
Suckling Period ◽  
Young Rats ◽  
Body Retention ◽  
Different Ages

The gastrointestinal absorption of Fe and Co by rats and guinea pigs of different ages was measured by comparing the whole-body retention of 59Fe and 57Co after oral and intraperitoneal administrations. The age-groups studied included newborn, weanlings and adults. The absorption of both Fe and Co decreased markedly with age in both rats and guinea pigs. In the rat, absorption remained ele vated during the suckling period, while in the guinea pig absorption decreased markedly during suckling. In both species, Fe and Co absorption were similar, and remained elevated above adult values for some time after weaning. The generally greater absorption of Fe and Co by rats than by guinea pigs and the longer duration of maximal absorp tion in the rats may have involved differences in Fe status in the two species and differences in the timing of gut mat uration.

scholarly journals Whole-body Retention and Tissue Distribution of Cesium-134 in New-born, Young and Adult Rats

1967 ◽  
Vol 8 (3-4) ◽  
pp. 132-140 ◽  
Author(s):  
Jiro INABA ◽  
Naonori MATSUSAKA ◽  
Ryushi ICHIKAWA
Keyword(s):  
Tissue Distribution ◽  
Whole Body ◽  
Adult Rats ◽  
New Born ◽  
Body Retention

scholarly journals Comparison of whole body retention of I-131 in case humans thyroid cancer between model prediction and measurement

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Brudecki Kamil ◽  
Mroz Tomasz ◽  
Janowski Paweł ◽  
Lorenc-Brudecka Jadwiga
Keyword(s):  
Thyroid Cancer ◽  
Model Prediction ◽  
Whole Body ◽  
Body Retention
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