Organ culture of human scalp hair follicles: effect of testosterone and oestrogen on hair growth

1990 ◽  
Vol 282 (7) ◽  
pp. 442-445 ◽  
Author(s):  
S. Kondo ◽  
Y. Hozumi ◽  
K. Aso
Keyword(s):  
Organ Culture ◽  
Hair Growth ◽  
Scalp Hair ◽  
Hair Follicles ◽  
Human Scalp Hair

scholarly journals Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles

2015 ◽  
Vol 135 (8) ◽  
pp. 2129-2132 ◽  
Author(s):  
Nathan J. Hawkshaw ◽  
Iain S. Haslam ◽  
David M. Ansell ◽  
Asim Shamalak ◽  
Ralf Paus
Keyword(s):  
Cyclosporine A ◽  
Hair Growth ◽  
Scalp Hair ◽  
Hair Follicles ◽  
Human Scalp Hair ◽  
Growth Promoting

scholarly journals Human Scalp Hair Follicles Are Both a Target and a Source of Prolactin, which Serves as an Autocrine and/or Paracrine Promoter of Apoptosis-Driven Hair Follicle Regression

2006 ◽  
Vol 168 (3) ◽  
pp. 748-756 ◽  
Author(s):  
Kerstin Foitzik ◽  
Karoline Krause ◽  
Franziska Conrad ◽  
Motonobu Nakamura ◽  
Wolfang Funk ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Scalp Hair ◽  
Hair Follicles ◽  
Human Scalp Hair

scholarly journals Estrogens and Human Scalp Hair Growth—Still More Questions than Answers

2004 ◽  
Vol 122 (3) ◽  
pp. 840-842 ◽  
Author(s):  
Franziska Conrad ◽  
Ulrich Ohnemus ◽  
Enikö Bodo ◽  
Albrecht Bettermann ◽  
Ralf Paus
Keyword(s):  
Hair Growth ◽  
Scalp Hair ◽  
Human Scalp Hair

scholarly journals Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using - FTIR-ATR Spectroscopy

2019 ◽  
Author(s):  
Padmavathi R ◽  
Gunasekaran S ◽  
Rajamannan B ◽  
Ramkumar GR ◽  
Sankari G ◽  
...  
Keyword(s):  
Scalp Hair ◽  
Acne Vulgaris ◽  
Hair Follicles ◽  
Pilosebaceous Unit ◽  
Tissue Samples ◽  
Spectral Signatures ◽  
Human Scalp Hair ◽  
Chronic Skin ◽  
Noninvasive Sample ◽  
Atr Spectroscopy

Acne vulgaris is a chronic skin disease which occurs due to inflammation of the hair follicles and sebum-producing (sebaceous) glands of the skin called pilosebaceous unit and the anaerobic propionic acne bacterium, P.acne. Human sebum is dominantly made up of 57.5% of triglycerides and fatty acids, 26%wax esters, 12% Squalene and 4.5% Cholesterol. The increased level Androgen hormone, sebum lipid composition, P.acne overgrowth which induces monocytes and pro-inflammatory cytokines attract neutrophils, basophils, and T cells to the pilosebaceous unit and drive epithelial hyperproliferation i.e., Acne vulgaris. The actual biomolecular changes due to acne vulgaris disease are present in the blood and in the sebum and also in the noninvasive sample of human scalp hair follicles. The main objectives of the present study are to analyze human scalp hair follicles samples using FTIR-ATR spectroscopy to compare and discriminate the spectral signatures of acne vulgaris and healthy scalp hair tissue samples through acne bio-markers Protein, Amide I, Amide II and Squalene (LDL), using the method of internal ratio parameters.

Evidence for Alpha-MSH Binding Sites on Human Scalp Hair Follicles: Preliminary Results

1991 ◽  
Vol 4 (4) ◽  
pp. 193-198 ◽  
Author(s):  
P.B. NANNINGA ◽  
G.E. GHANEM ◽  
F.J. LEJEUNE ◽  
J.D. BOS ◽  
W. WESTERHOF
Keyword(s):  
Binding Sites ◽  
Scalp Hair ◽  
Hair Follicles ◽  
Preliminary Results ◽  
Human Scalp Hair

scholarly journals Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles

PLoS Biology ◽  
2018 ◽  
Vol 16 (5) ◽  
pp. e2003705 ◽  
Author(s):  
Nathan J. Hawkshaw ◽  
Jonathan A. Hardman ◽  
Iain S. Haslam ◽  
Asim Shahmalak ◽  
Amos Gilhar ◽  
...  
Keyword(s):  
Hair Loss ◽  
Cyclosporine A ◽  
Human Hair ◽  
Scalp Hair ◽  
Dermal Papilla ◽  
Hair Follicles ◽  
Human Scalp Hair ◽  
Wnt Inhibitor

Protein biosynthesis in isolated human scalp hair follicles

1978 ◽  
Vol 4 (4) ◽  
pp. 211-216 ◽  
Author(s):  
A. J. M. Vermorken ◽  
P. J. J. M. Weterings ◽  
H. Bloemendal
Keyword(s):  
Scalp Hair ◽  
Protein Biosynthesis ◽  
Hair Follicles ◽  
Human Scalp Hair

scholarly journals Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mira Choi ◽  
Soon-Jin Choi ◽  
Sunhyae Jang ◽  
Hye-In Choi ◽  
Bo-Mi Kang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Organ Culture ◽  
Human Hair ◽  
Hair Growth ◽  
Shikimic Acid ◽  
Ex Vivo ◽  
Hair Follicles ◽  
Anagen Hair

AbstractShikimic acid (SA) has recently been found to be a major component of plant stem cells. The exact effects of SA on human hair follicles (HFs) is unknown. The purpose of this study was to examine the effects of SA on hair growth. We investigated the effect of SA on an in vivo C57BL/6 mouse model. We examined the expression of mannose receptor (MR), which is a known receptor of SA, in human HFs and the effect of SA on human dermal papilla cells (hDPCs), outer root sheath cells (hORSCs), and on ex vivo human hair organ culture. SA significantly prolonged anagen hair growth in the in vivo mouse model. We confirmed expression of the MR in human HFs, and that SA increased the proliferation of hDPCs and hORSCs. It was found that SA enhanced hair shaft elongation in an ex vivo human hair organ culture. SA treatment of hDPCs led to increased c-myc, hepatocyte growth factor, keratinocyte growth factor and vascular endothelial growth factor levels and upregulation of p38 MAPK and cAMP response element-binding protein levels. Our results show that SA promotes hair growth and may serve as a new therapeutic agent in the treatment of alopecia.

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