Lipid metabolism in differentiating central nervous system in chick

1967 ◽  
Vol 159 (2) ◽  
pp. 267-272 ◽  
Author(s):  
J. Medda ◽  
A. Bose
1985 ◽  
Vol 3 ◽  
pp. S23
Author(s):  
Shunichi Murano ◽  
Kohji Shirai ◽  
Yasushi Saito ◽  
Sho Yoshida

2015 ◽  
Vol 4 (2) ◽  
pp. 112-115
Author(s):  
Lyudmila Viktorovna Ledyaikina ◽  
Larisa Alexandrovna Balykova ◽  
Svetlana Vasilyevna Garina ◽  
Olga Nikolaevna Soldatova ◽  
A A Tolkunova ◽  
...  

The problem of perinatal morbidity in case of insufficiently high fertility in Russia is one of the most relevant at the monent. The leading cause of perinatal morbidity and mortality continue to remain hypoxic-ischemic brain damage the fetus and newborn. Ischemic-hypoxic damage of the central nervous system (CNS) is the most dangerous and prognostic significance. They often fatal and takes a leading role in the future of children and maladjustment of severe disabling diseases. Introduction of innovative medical technologies in health care practice greatly enhances the study of the causes of many diseases and abnormalities in newborns and helps to clarify the etiology, pathogenetic mechanisms, clinical and morphological structure, as well as typical for different gestational age localization of brain damage. It is shown that the generalized disorder of lipid metabolism with the development membranodestruktive processes is closely correlated with the severity of hypoxic-ischemic lesions of the central nervous system. It was found that infants who underwent antenatal and / or intranatal hypoxia, there are significant transformation of lipid metabolism lead to changes in the composition of lipids of blood plasma and red blood cells (with the accumulation level of chaotropic fractions phospholipid bilayer membranes of red blood cells - Lizoform phospholipids and free fatty acids). The necessity inclusion complex therapy consequences of perinatal hypoxia drugs, which have antioxidant, antihypoxic activity and the ability to regulate lipid metabolism.


1985 ◽  
Vol 1 ◽  
pp. S23
Author(s):  
Shunichi Murano ◽  
Kohji Shirai ◽  
Yasushi Saito ◽  
Sho Yoshida

Author(s):  
Antonella Mandas

The physiology and the pathology of the Central Nervous System (CNS) is very complex, and only by understanding it the scientific research might develop effective treatments. Neurocognitive Disorders, extremely diffused diseases, have a multifactorial aetiology, in which lipid homeostasis plays an important role, as known. The aim of this mini-review is focus on interesting recently published researches on the topic, in order to put together some pieces of the puzzle of such an enormous physiopathology chapter. After a brief introduction, we will describe important aspects of CNS lipid metabolism, then we will examine the conclusions of recent articles relating to lipid role in neurodegeneration. The recent scientific literature has strengthened the position of some well-known “biological agents” – i.e. lipid peroxidation and apolipoprotein E4 allele –but also detailed the importance of new promising diagnostic and therapeutic targets.


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