Poor patient compliance reduces the efficacy of metrifonate treatment ofSchistosoma haematobium in Somalia

1989 ◽  
Vol 36 (2) ◽  
pp. 161-164 ◽  
Author(s):  
Y. Aden Abdi ◽  
L. L. Gustafsson
Keyword(s):  
Patient Compliance ◽  
Poor Patient ◽  
Poor Patient Compliance

Recent Developments in Alpha-Glucosidase Inhibitors for Management of Type-2 Diabetes: An Update

2019 ◽  
Vol 25 (23) ◽  
pp. 2510-2525 ◽  
Author(s):  
Bashir Usman ◽  
Neha Sharma ◽  
Saurabh Satija ◽  
Meenu Mehta ◽  
Manish Vyas ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Patient Compliance ◽  
Postprandial Hyperglycemia ◽  
Diabetic Patients ◽  
Poor Patient ◽  
Glucosidase Inhibitors ◽  
Poor Patient Compliance ◽  
Recent Developments ◽  
Alpha Glucosidase

The incidence of diabetes has increased globally in recent years and figures of diabetic patients were estimated to rise up to 642 million by 2040. The disorder is accompanied with various complications if not managed at the early stages, and interlinked high mortality rate and morbidity with time. Different classes of drugs are available for the management of type 2 diabetes but were having certain limitations of their safety. Alphaglucosidase is a family of enzyme originated from the pancreas which plays a role in the anabolism of 80-90% of carbohydrate consumed into glucose. This glucose is absorbed into the blood and results in frank postprandial hyperglycemia and worsens the conditions of diabetic patients which precipitate complications. Inhibition of these enzymes helps to prevent postprandial hyperglycemia and the formation of glycated end products. Alphaglucosidase inhibitors are reported to be more important in adequate control of type 2, but marketed drugs have various side effects, such as poor patient compliance and also expensive. This proves the needs for other class of drugs with better efficacy, safety, patient compliance and economic. In this review, we have emphasized the recent advances in the field of new alpha-glucosidase inhibitors with improved safety and pharmacological profile.

scholarly journals Mnenje pulmologov o pomenu vdihovalnikov pri bolnikih z astmo ali KOPB

2017 ◽  
Vol 86 (3-4) ◽  
Author(s):  
Mitja Košnik ◽  
Nadja Triller ◽  
Julij Šelb
Keyword(s):  
Disease Control ◽  
General Practitioners ◽  
Patient Compliance ◽  
Delphi Method ◽  
Interquartile Range ◽  
Critical Event ◽  
Two Stage ◽  
Poor Patient ◽  
Poor Patient Compliance ◽  
Selection Of

Background: Medications for asthma and COPD are mainly used in the form of inhalations. A survey was performed to obtain the opinion of experts about the importance of inhalers in inhaled drug therapy.Methods: All members–pulmonologists of the Slovenian Respiratory Society were invited to participate in the survey using a two-stage Delphi method. The result of each response were shown by the median and interquartile range, whereby we calculated the level of consensus.Results: 176 doctors were invited. Most questions were answered by 49 (27.8 %) participants. In the second round 42 doctors responded. As many as 33 out of 41 respondents (80.5 %) felt that in the treatment of asthma and COPD the selection of medicines and inhalers are equally important. When choosing an inhaler, it is crucial that it is simple to instruct the patients about its use. Respondents highly agreed with the statement that patients should receive a prescription for inhaler only after they have been trained on how to use it. As appropriate persons for the training of patients on the use of inhalers the respondents recognized (from most to least suitable) pulmonologists, nurses, general practitioners or pharmacists. 53.8 % of respondents considered that the patient’s skill of the use of inhaler should be checked on every visit to the doctor. Respondents believed that replacing inhalers without consulting the treating doctor may result in incorrect use of the inhaler, poor patient compliance, more exacerbations of the disease and poorer disease control. Some consensus with an indifferent median of 4.5 was reached with regard to the argument that the doctor should prescribe the inhaler that is the cheapest for society.Conclusions: Slovenian pulmonologists believe that any change of inhaler is a critical event, which must be coordinated with the patient and the doctor.

scholarly journals Study on Factors that Contribute to Poor Patient Compliance with Medication in Japan.

1999 ◽  
Vol 25 (6) ◽  
pp. 634-642 ◽  
Author(s):  
HIROMI HASHIMOTO ◽  
MASAYO TANAKA ◽  
TADASHI OYAKE ◽  
TOMOKO GOMI ◽  
TOSHIO IKEDA ◽  
...  
Keyword(s):  
Patient Compliance ◽  
Poor Patient ◽  
Poor Patient Compliance

Paroxetine Hydrochloride Push-pull Osmotic Pump Tablets: Designing an Innovative, Scalable Push-pull Osmotic Drug Delivery System Using QbD Approach

2020 ◽  
Vol 10 (2) ◽  
pp. 104-116
Author(s):  
Prathmesh P. Kenjale ◽  
Manjusha A. Joshi ◽  
Umesh N. Khatavkar ◽  
Vividha V. Dhapte ◽  
Varsha B. Pokharkar
Keyword(s):  
Patient Compliance ◽  
Risk Mitigation ◽  
Release Kinetics ◽  
In Vitro Release ◽  
Osmotic Pump ◽  
Wet Granulation ◽  
Poor Patient ◽  
Poor Patient Compliance ◽  
Paroxetine Hydrochloride

Background: Paroxetine hydrochloride hemihydrate (PHH) is a serotonin reuptake inhibitor useful for the treatment of diverse psychiatric problems. Existing marketed formulations with frequent administration lead to gastrointestinal (GI) reactions and abrupt fluctuations in plasma level with poor patient compliance. These prerequisites are sufficed by controlled release push-pull osmotic pump tablets (PPOP). Objective: Objective of the present study was to develop robust and reliable PPOP formulation via Quality by design (QbD) approach to achieve desired release kinetics. Methods: PPOP was formulated using wet granulation method followed by osmotic coating. QbD strategy for defining the risk assessment of influential variables such as swelling polymers and osmogen on in vitro release kinetics of designed PPOP. Results: Presence of Polyox in push and pull layer along with osmogen controlled the drug release pattern from formulated PPOP system as depicted in 33 factorial design. These formulated optimized PPOP systems demonstrated 2 hrs lag time with zero-order kinetics, a peculiar feature of PPOPs. Conclusions: Scalable, stable PPOP tablets were fabricated by applying systematic QbD approach. The developed PPOP systems with improved concentration-independent behavior helped to address the challenges of existing marketed formulations. Risk mitigation and control strategy assured quality of the system during scalability. Application of QbD strategy in establishing the PPOP formulation would help in formulating drug candidates having gastric limitations and poor patient compliance. The present study is the detailed account of QbD based PPOP formulation, therefore it can be of potential importance from academics as well as industrial perspective.

scholarly journals Analysis of price variation of some commonly used antibacterial agents

2019 ◽  
Vol 8 (7) ◽  
pp. 1567
Author(s):  
Rohan Srivastava ◽  
Naresh D. Kantharia
Keyword(s):  
Patient Compliance ◽  
Antibacterial Agents ◽  
Price Ratio ◽  
Price Variation ◽  
Poor Patient ◽  
Poor Patient Compliance ◽  
Price Range ◽  
Maximum Price ◽  
Parenteral Formulations ◽  
Oral Antibacterial

Background: Antimicrobial resistance is a serious problem. Resistance may develop due to irrational use including poor patient compliance due to prescription of expensive drugs. In present study, the variation in the price of commonly used antibacterial was analysed.Methods: The price of commonly used antibacterial agents listed in recent issues of CIMS and MIMS was analysed in respect of number of brands available, price range (10 tablets or capsules) and 1 ampoule or vial (parenteral preparation) i.e. minimum, maximum and average price and price ratio (maximum/minimum). FDCs and formulation with only 1-2 brands were excluded.Results: The number of brands of oral antibacterial agents varied from 3 (faropenem 200 mg) to 90 (azithromycin 500 mg). The maximum price variation amongst different brands was 21.64 for levofloxacin 500 mg followed by 14.28 and 11.26 for linezolid 600 mg and moxifloxacin 400 mg respectively. For parenteral preparations, the number of brands varied from 2 (gentamicin 80 mg) to 57 (ceftriaxone 1 g). The maximum price variation was 5.05 for meropenem 1 g followed by 3.69 and 2.63 for meropenem 500 mg and ceftriaxone 1 g respectively.Conclusions: A very wide price variation was observed amongst different brands of both oral and parenteral formulations of antibacterial agents. Prescribing expensive brands may lead to resistance due to poor patient compliance.

scholarly journals Safe and appropriate use of laxatives for colonoscopy

2021 ◽  
Vol 64 (8) ◽  
pp. 561-569
Author(s):  
Won Shik Kim ◽  
Beom Jae Lee
Keyword(s):  
Polyethylene Glycol ◽  
Patient Education ◽  
Patient Compliance ◽  
Bowel Preparation ◽  
Gas Bubbles ◽  
Appropriate Use ◽  
Poor Patient ◽  
Poor Patient Compliance ◽  
Underlying Diseases

Background: Appropriate bowel preparation is essential for effective colonoscopy. Inadequate use of bowel preparation solutions reduces patient compliance, makes the detection of lesions such as adenoma difficult, and increases the risk of complication such as perforation. Current Concepts: A 4-L polyethylene glycol (PEG) solution can be safely used for bowel preparation, even in most individuals with underlying diseases. However, it requires a high preparation-volume intake and has poor patient compliance due to its unpleasant taste. Therefore, a 2- or 1- L sulfate-free, PEG-based laxative was developed to, reduce the amount of PEG and improve the taste. Furthermore, simethicon-containing laxative formulation was developed to eliminate gas bubbles. In addition, oral bowel preparation solutions with enema agents and prokinetics were used to improve bowel preparation, but no improvement was observed. Various alternative laxatives are available; however, PEG-based bowel preparation solutions are still recommended in most cases due to their stability. Discussion and Conclusion: Although a 4-L PEG solutions recommended for bowel preparation in most cases, several laxatives have been introduced to overcome its disadvantages. The laxative agent must be selected according to each patient’s specific characteristics. Moreover, the method of taking bowel preparation solutions and additional bowel preparation medications must be carefully chosen. In addition, patient education via various methods, such as using a smartphone, when taking a bowel preparation agent may help improve bowel preparation quality.

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