Aluminium chloride induced meiotic chromosome aberrations in the grasshopper, phloeoba antennata

The term interchromosomal effect was originally used to describe a change in the distribution of exchange in the presence of an inversion. First characterized in the 1920s by early Drosophila researchers, it has been observed in multiple organisms. Nearly half a century later, the term began to appear in the human genetics literature to describe the hypothesis that parental chromosome differences, such as translocations or inversions, may increase the frequency of meiotic chromosome nondisjunction. Although it remains unclear if chromosome aberrations truly affect the segregation of structurally normal chromosomes in humans, the use of the term interchromosomal effect in this context persists. This article explores the history of the use of the term interchromosomal effect and discusses how chromosomes with structural aberrations are segregated during meiosis.

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SPONTANEOUS MEIOTIC CHROMOSOME ABNORMALITIES IN MALE MICE (MUS MUSCULUS)

Canadian Journal of Genetics and Cytology ◽

10.1139/g71-014 ◽

1971 ◽

Vol 13 (1) ◽

pp. 95-100 ◽

Cited By ~ 13

Author(s):

Chyi-Chyang Lin ◽

W. S. Tsuchida ◽

S. A. Morris

Keyword(s):

Mus Musculus ◽

Chromosome Aberrations ◽

Meiotic Chromosome ◽

Chromosome Abnormalities ◽

Male Mice ◽

Chromosome Anomalies

Three types of spontaneous meiotic chromosome aberrations were described in mouse spermatocytes: (1) Precocious separation of XY chromosomes was observed in about 6% of cells in diakinesis and first metaphase; (2) chromosome degeneration appeared in 9.2 and 4.8% of cells at pachytene and at first metaphase, respectively; (3) polyploidy, in particular tetraploidy, occurred in 2.7 and 3.2% of cells at pachytene and first metaphase, respectively. These chromosome anomalies should be considered in cytological studies of the effect of noxious agents on chromosomes in mouse spermatocytes.

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Influence of aluminium chloride and sulphate on the root meristem of Vicia faba L.

Acta Societatis Botanicorum Poloniae ◽

10.5586/asbp.1983.020 ◽

2014 ◽

Vol 52 (3-4) ◽

pp. 185-195 ◽

Cited By ~ 8

Author(s):

Barbara Wojciechowska ◽

Halina Kocik

Keyword(s):

Mitotic Activity ◽

Vicia Faba ◽

Chromosome Aberrations ◽

Root Meristem ◽

Aluminium Chloride ◽

Aluminium Sulphate ◽

Binuclear Cells ◽

Vicia Faba L

The influence of various (0.1, 0.05, 0.01, 0.001 and 0.0001 M) aluminium chloride and aluminium sulphate concentrations on the mitotic activity of the root meristem of the bean <em>Vicia faba</em> L. was investigated after 24 h of incubation. A mito-depressive action of the tested compounds, irreversible at higher concentrations was observed. The tested substances induced chromosome aberrations (fragmentation and bridges in anaphase or telophase, micronuclei, binuclear cells) and inhibited elongation of roots. The results of topochemical analysis are described.

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Role of telomeres and centromeres in meiotic chromosome pairing

AccessScience ◽

10.1036/1097-8542.yb120238 ◽

2015 ◽

Keyword(s):

Chromosome Pairing ◽

Meiotic Chromosome ◽

Meiotic Chromosome Pairing

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Bestimmung der DNA-Schädigung in vitro

Nuklearmedizin ◽

10.1055/s-0038-1626526 ◽

2010 ◽

Vol 49 (S 01) ◽

pp. S64-S68

Author(s):

E. Dikomey

Keyword(s):

Dna Damage ◽

Cell Lines ◽

Chromosome Aberrations ◽

Genetic Factors ◽

Double Strand Breaks ◽

Strand Breaks ◽

Cell Inactivation ◽

Repair Mechanisms ◽

Break Repair

SummaryIonising irradiation acts primarily via induction of DNA damage, among which doublestrand breaks are the most important lesions. These lesions may lead to lethal chromosome aberrations, which are the main reason for cell inactivation. Double-strand breaks can be repaired by several different mechanisms. The regulation of these mechanisms appears be fairly different for normal and tumour cells. Among different cell lines capacity of doublestrand break repair varies by only few percents and is known to be determined mostly by genetic factors. Knowledge about doublestrand break repair mechanisms and their regulation is important for the optimal application of ionising irradiation in medicine.

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