SPONTANEOUS MEIOTIC CHROMOSOME ABNORMALITIES IN MALE MICE (MUS MUSCULUS)

Three types of spontaneous meiotic chromosome aberrations were described in mouse spermatocytes: (1) Precocious separation of XY chromosomes was observed in about 6% of cells in diakinesis and first metaphase; (2) chromosome degeneration appeared in 9.2 and 4.8% of cells at pachytene and at first metaphase, respectively; (3) polyploidy, in particular tetraploidy, occurred in 2.7 and 3.2% of cells at pachytene and first metaphase, respectively. These chromosome anomalies should be considered in cytological studies of the effect of noxious agents on chromosomes in mouse spermatocytes.

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Synaptonemal complex damage in relation to meiotic chromosome aberrations after exposure of male mice to cyclophosphamide

Mutation Research/Environmental Mutagenesis and Related Subjects ◽

10.1016/0165-1161(88)90021-0 ◽

1988 ◽

Vol 203 (4) ◽

pp. 317-330 ◽

Cited By ~ 46

Author(s):

L.C. Backer ◽

J.B. Gibson ◽

M.J. Moses ◽

J.W. Allen

Keyword(s):

Synaptonemal Complex ◽

Chromosome Aberrations ◽

Meiotic Chromosome ◽

Male Mice

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Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus)

Journal of Hazardous Materials ◽

10.1016/j.jhazmat.2020.124644 ◽

2021 ◽

Vol 406 ◽

pp. 124644

Author(s):

Yongfeng Deng ◽

Zehua Yan ◽

Ruqin Shen ◽

Yichao Huang ◽

Hongqiang Ren ◽

...

Keyword(s):

Mus Musculus ◽

Male Mice

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Aluminium chloride induced meiotic chromosome aberrations in the grasshopper, phloeoba antennata

The Science of Nature ◽

10.1007/bf00637706 ◽

1965 ◽

Vol 52 (23) ◽

pp. 647-648 ◽

Cited By ~ 6

Author(s):

G. K. Manna ◽

B. B. Parida

Keyword(s):

Chromosome Aberrations ◽

Meiotic Chromosome ◽

Aluminium Chloride

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Behavioral Characterization of Wild Derived Male Mice (Mus musculus musculus) of the PWD/Ph Inbred Strain: High Exploration Compared to C57BL/6J

Behavior Genetics ◽

10.1007/s10519-004-5589-y ◽

2004 ◽

Vol 34 (6) ◽

pp. 621-630 ◽

Cited By ~ 19

Author(s):

Cathy Fernandes ◽

Lin Liu ◽

Jos� L. Paya-Cano ◽

So?a Gregorov� ◽

Ji?� Forejt ◽

...

Keyword(s):

Inbred Strain ◽

Mus Musculus ◽

Male Mice ◽

Mus Musculus Musculus ◽

Behavioral Characterization

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Noise Exposure Decreases the Number of Spermatozoa in Male Mice (Mus musculus L.) Even With Grape Seed Extract (Vitis vinifera L.) Administration

WMJ (Warmadewa Medical Journal) ◽

10.22225/wmj.5.2.1785.70-75 ◽

2020 ◽

Vol 5 (2) ◽

pp. 70-75

Author(s):

Ghestiara Siregar

Keyword(s):

Treatment Group ◽

Mus Musculus ◽

Noise Exposure ◽

Grape Seed Extract ◽

Grape Seed ◽

Seed Extract ◽

Control Group ◽

Vitis Vinifera L ◽

Not Given ◽

Male Mice

Excessive continuous noises exposure changes the male hormone system which leads to formation of oxidative stress and results in disrupt of semen quality. This condition can be reduced by the use of antioxidants. Grape seed is one of the antioxidants that contains phenol components that have Resveratrol compounds. This research aimed to observe the effect of noise exposure on the number of spermatozoa of male mice given grape seed extract. The method of the research was a post-test only control group design with research subjects of 30 male Mus musculus L. (Swiss Webster) mice divided into 5 groups: group A (treatment control) was not given noise exposure and grape seed extract, group B (negative control) was not given noise exposure and was given grape seed extract, groups C, D, E (treatment group) were given noise exposure with sequential intensities of 65 dB, 85 dB, 105 dB. The treatment was given for 33 days. The results showed that noise exposure with different intensities of 65 dB, 85 dB, 105 dB reduced the spermatozoa count of male Swiss Webster mice even with the administration of grape seed extract. One Way Anova test was used to analyze the data with p-value of 0.001. Conclusion: There were differences in spermatozoa count between the control group and the treatment group. Provision of noise exposure with a value above the threshold limit reduces the number of male Swiss Webster mice spermatozoa given with grape seed extract. Keywords: Number of Spermatozoa, Grape Seed Extract, Noise exposure

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Bioactivity of Torch Ginger Umbut Extract (Etlingera elatior) Against Heal Wounds of Mice (Mus musculus)

EKSAKTA Berkala Ilmiah Bidang MIPA ◽

10.24036/eksakta/vol21-iss2/230 ◽

2020 ◽

Vol 21 (2) ◽

pp. 124-130

Author(s):

Mhd Zalil Efendi ◽

Ramadhan Sumarmin ◽

M. Syukri Fadil

Keyword(s):

Wound Healing ◽

Adult Male ◽

Mus Musculus ◽

Male Mice ◽

Pharmacological Activities ◽

Active Compounds ◽

Randomized Design ◽

Wide Range ◽

Completely Randomized Design ◽

Etlingera Elatior

Torch ginger has a wide range of good antimicrobial, antioxidant, anticancer, larvicidal and repellent activities. Active compounds in Torch ginger that affect pharmacological activities are phenols, polyphenols, flavonoids, and terpenoids. Based on these ingredients Torch ginger can be used to heal wounds. This study aims to observe the effect of Torch ginger Umbut extract on wound healing in mice. This study hopes to add information about the effect of Torch ginger umbut extract on the healing of cuts in mice so that it can be another alternative for wound healing and can be a reference for other researchers. This study used a completely randomized design with 5 treatments and 3 replications. Tests carried out on adult male mice. The results showed that the optimal wound healing in P2 is treatment with 10% Torch ginger umbut extract which requires a range of wound healing 7-8 days. Based on these results, Torch ginger umbut extract can heal wounds.

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The scent of urine spots of male mice,Mus musculus: changes in chemical composition over time

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.2789 ◽

2006 ◽

Vol 20 (24) ◽

pp. 3741-3746 ◽

Cited By ~ 17

Author(s):

Andrea Cavaggioni ◽

Carla Mucignat-Caretta ◽

Marco Redaelli ◽

Giuseppe Zagotto

Keyword(s):

Chemical Composition ◽

Mus Musculus ◽

Male Mice ◽

Over Time

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Prevalence of chromosome anomalies in a deer farm with fertility decline in Malaysia

Future Science OA ◽

10.2144/fsoa-2020-0037 ◽

2020 ◽

Vol 6 (6) ◽

pp. FSO580

Author(s):

Muhammad Sanusi Yahaya ◽

Mohd Shahrom Salisi ◽

Nur Mahiza Md Isa ◽

Goh Yong Meng ◽

Abdwahid Haron

Keyword(s):

Chromosomal Aberrations ◽

Chromosome Aberrations ◽

Fertility Decline ◽

Unknown Origin ◽

Structural Rearrangements ◽

Blood Samples ◽

Chromosome Anomalies ◽

Number Of Factors ◽

Axis Axis ◽

History Of

Background: A number of factors are known to reduce fertility rate in animals and one of the important categories of such factors is chromosome anomalies. They can occur with or without causing phenotypic abnormalities on animals; in some cases, they may directly affect meiosis, gametogenesis and the viability of conceptus. In many instances, balanced structural rearrangements can be transmitted to offspring, affecting fertility in subsequent generations. Aim: This work investigated the occurrence of chromosome aberrations in Rusa timorensis, Rusa unicolor and Axis axis raised in a nucleus deer farm in Malaysia with a history of declining fertility of unknown origin. Materials & methods: Blood samples were collected from 60 animals through venipuncture, cultured for 72 h and arrested at metaphase. SmartType® and Ideokar® software were used to karyotype the chromosomes. Results: We found 15 out of the 60 animals screened from both sexes harbor some form of chromosome aberration. Chromosomal aberrations exist at the rate of 25% and may not be unconnected with the observed reduced fertility on the farm. Further investigations should be carried out, especially on the offspring of the studied animals to transmission of these aberrations. The animals that are confirmed to transmit the chromosomal aberrations should be culled to arrest the propagation of their abnormalities.

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