Nucleolar apparatus of AKR mouse lymphoid cells at different stages of leukemia development

1990 ◽  
Vol 110 (5) ◽  
pp. 1565-1568
Author(s):  
N. V. Levitan ◽  
M. I. Loseva ◽  
G. N. Shorina ◽  
G. S. Yakobson
Keyword(s):  
Lymphoid Cells ◽  
Nucleolar Apparatus ◽  
Leukemia Development

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells

Blood ◽  
2008 ◽  
Vol 111 (2) ◽  
pp. 829-837 ◽  
Author(s):  
Venturina Stagni ◽  
Maria Giovanna di Bari ◽  
Silvia Cursi ◽  
Ivano Condò ◽  
Maria Teresa Cencioni ◽  
...  
Keyword(s):  
Immune System ◽  
Hodgkin Lymphoma ◽  
Kinase Activity ◽  
Lymphoid Cells ◽  
Atm Kinase ◽  
Protein Levels ◽  
Damage Response ◽  
Leukemia Development ◽  
Induced Apoptosis

Ataxia telangiectasia (A-T) is a rare cancer-predisposing genetic disease, caused by the lack of functional ATM kinase, a major actor of the double strand brakes (DSB) DNA-damage response. A-T patients show a broad and diverse phenotype, which includes an increased rate of lymphoma and leukemia development. Fas-induced apoptosis plays a fundamental role in the homeostasis of the immune system and its defects have been associated with autoimmunity and lymphoma development. We therefore investigated the role of ATM kinase in Fas-induced apoptosis. Using A-T lymphoid cells, we could show that ATM deficiency causes resistance to Fas-induced apoptosis. A-T cells up-regulate FLIP protein levels, a well-known inhibitor of Fas-induced apoptosis. Reconstitution of ATM kinase activity was sufficient to decrease FLIP levels and to restore Fas sensitivity. Conversely, genetic and pharmacologic ATM kinase inactivation resulted in FLIP protein up-regulation and Fas resistance. Both ATM and FLIP are aberrantly regulated in Hodgkin lymphoma. Importantly, we found that reconstitution of ATM kinase activity decreases FLIP protein levels and restores Fas sensitivity in Hodgkin lymphoma–derived cells. Overall, these data identify a novel molecular mechanism through which ATM kinase may regulate the immune system homeostasis and impair lymphoma development.

Lymphoproliferative disorders (LPD) involving lungs: T and B cell subsets within pulmonary infiltrates and in peripheral blood

1984 ◽  
Vol 42 ◽  
pp. 700-701
Author(s):  
Irene Stachura ◽  
Milton H. Dalbow ◽  
Michael J. Niemiec ◽  
Matias Pardo ◽  
Gurmukh Singh ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Lymphoproliferative Disorders ◽  
Mixed Population ◽  
Lymphoid Cells ◽  
Lymphomatoid Granulomatosis ◽  
Cell Type ◽  
Cell Surface Antigens ◽  
Pulmonary Infiltrates ◽  
B Cell Subsets

Lymphoid cells were analyzed within pulmonary infiltrates of six patients with lymphoproliferative disorders involving lungs by immunofluorescence and immunoperoxidase techniques utilizing monoclonal antibodies to cell surface antigens T11 (total T), T4 (inducer/helper T), T8 (cytotoxic/suppressor T) and B1 (B cells) and the antisera against heavy (G,A,M) and light (kappa, lambda) immunoglobulin chains. Three patients had pseudolymphoma, two patients had lymphoma and one patient had lymphomatoid granulomatosis.A mixed population of cells was present in tissue infiltrates from the three patients with pseudolymphoma, IgM-kappa producing cells constituted the main B cell type in one patient. In two patients with lymphoma pattern the infiltrates were composed exclusively of T4+ cells and IgG-lambda B cells predominated slightly in the patient with lymphomatoid granulomatosis.

Author response for "NK1.1 + innate lymphoid cells in salivary glands inhibit establishment of tissue‐resident memory CD8 + T cells in mice"

2020 ◽  
Author(s):  
Sandra Woyciechowski ◽  
Kristoffer Weißert ◽  
Sandra Ammann ◽  
Peter Aichele ◽  
Hanspeter Pircher
Keyword(s):  
T Cells ◽  
Salivary Glands ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Author Response

A pro-inflammatory role of type 2 innate lymphoid cells in murine immune-mediated hepatitis

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
K Karimi ◽  
K Neumann ◽  
J Meiners ◽  
R Voetlause ◽  
W Dammermann ◽  
...  
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Immune Mediated

LYMPHOID INFILTRATION IN TOXIC GOITRES STUDIED WITH FINE NEEDLE ASPIRATION BIOPSY

1972 ◽  
Vol 71 (3) ◽  
pp. 480-490 ◽  
Author(s):  
Göran Nilsson
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Lymphoid Cells ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Needle Aspiration Biopsy ◽  
Lymphoid Infiltration ◽  
Long Acting

ABSTRACT Cytodiagnostic fine needle aspiration biopsy specimens from toxic goitres were studied for signs of lymphoid infiltration. Comparison with histological sections of specimens obtained by surgery showed that an excess of lymphoid cells in the aspirate smears corresponded to a large number of lymphoid foci in these sections. Excess of lymphoid cells in the fine needle aspirates was also positively correlated with the occurrence of circulating thyroid antibodies against thyroglobulin and/or cytoplasmic antigen, but not with the presence of the long-acting thyroid stimulating factor, LATS. It also varied with age in that it was most common in the youngest patients and in patients between 40–55 years, while lymphoid infiltration was seldom seen in patients over 55 years. A finding of practical clinical interest was that in toxic goitres with cytological signs of lymphoid infiltration hyperthyroidism had less tendency to recur after treatment with thiocarbamide drugs than in those without such signs.

Activity of interferon-dependent 2', 5'-oligoadenylate synthetase in rat lymphoid cells under transformed environment conditions

2007 ◽  
Vol 13 (2) ◽  
pp. 69-74
Author(s):  
L.I. Ostapchenko ◽  
◽  
I.V. Mikhailik ◽  
K.V. Prokopova ◽  
◽  
...  
Keyword(s):  
Lymphoid Cells ◽  
Oligoadenylate Synthetase

1886-P: Hepatic Type 2 Innate Lymphoid Cells Suppress Gluconeogenesis via the IL-33/GATA3/IL-13 Axis

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1886-P
Author(s):  
MASANORI FUJIMOTO ◽  
KOUTARO YOKOTE ◽  
TOMOAKI TANAKA
Keyword(s):  
Innate Lymphoid Cells ◽  
Lymphoid Cells
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