Proliferation activity and bacteriostatic potential of human blood monocytes, macrophages in pleural effusions, ascites, and of alveolar macrophages

1980 ◽  
Vol 40 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Gerhard Meuret ◽  
Otto Schildknecht ◽  
Peter Joder ◽  
Hansj�rg Senn
Keyword(s):  
Human Blood ◽  
Alveolar Macrophages ◽  
Blood Monocytes ◽  
Pleural Effusions ◽  
Proliferation Activity

Dyscoordinate Expression of Tumor Necrosis Factor-alpha by Human Blood Monocytes and Alveolar Macrophages

1989 ◽  
Vol 139 (4) ◽  
pp. 1010-1016 ◽  
Author(s):  
Elizabeth A. Rich ◽  
James R. Panuska ◽  
Robert S. Wallis ◽  
Christopher B. Wolf ◽  
Michelle L. Leonard ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Human Blood ◽  
Alveolar Macrophages ◽  
Tumor Necrosis ◽  
Blood Monocytes ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Gene Expression of Macrophage Inflammatory Protein-1αfrom Human Blood Monocytes and Alveolar Macrophages Is Inhibited by Interleukin-4

1993 ◽  
Vol 9 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Theodore J. Standiford ◽  
Steven L. Kunkel ◽  
Janice M. Liebler ◽  
Marie D. Bur dick ◽  
Andrew R. Gilbert ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Blood ◽  
Alveolar Macrophages ◽  
Interleukin 4 ◽  
Blood Monocytes ◽  
Inflammatory Protein ◽  
Macrophage Inflammatory Protein

An In Vitro Method for Examining the Effects of Human Monocytes on the Durability of Glass Fibres

1988 ◽  
Vol 16 (2) ◽  
pp. 155-161
Author(s):  
Paul J. Conroy ◽  
John Young ◽  
David G. Dewhurst ◽  
David W. Allen ◽  
Anthony Clark
Keyword(s):  
Human Blood ◽  
Glass Fibre ◽  
Alveolar Macrophages ◽  
Human Monocytes ◽  
Blood Monocytes ◽  
Isolated Cells ◽  
In Vitro Method ◽  
Glass Fibres ◽  
Dynamic Cell

An in vitro method for characterising the degradation of glass fibres in an intramacrophage-type environment is reported. Human blood monocytes provide the phagocytically active cultures and a “semi-dynamic cell replenishment method”, whereby cultures are replenished every three weeks with monocytes from the same donor, has enabled exposure times exceeding 26 weeks to be achieved. Tests indicated an affinity of monocytes for glass fibre, and superoxide activity in freshly isolated cells was measured and found to be comparable with that for alveolar macrophages.

scholarly journals Migrating lung monocytes internalize and inhibit growth of Aspergillus fumigatus conidia

2020 ◽  
Author(s):  
Natalia Schiefermeier-Mach ◽  
Thomas Haller ◽  
Stephan Geley ◽  
Susanne Perkhofer
Keyword(s):  
Aspergillus Fumigatus ◽  
Human Blood ◽  
Alveolar Macrophages ◽  
Hyphal Growth ◽  
Blood Monocytes ◽  
Alveolar Cells ◽  
Transcriptional Responses ◽  
Present Fungus ◽  
Locomotory Behaviour

AbstractMonocytes are important players to combat ubiquitously present fungus Aspergillus fumigatus. Recruitment of monocytes to sites of fungal infection was shown in vivo, and purified murine and human blood monocytes are able to induce inflammatory and fungicidal mediators as well as the host cell and the fungal transcriptional responses upon exposure to A.fumigatus. Mononuclear tissue phagocytes are phenotypically and functionally different from those circulating in the blood and their role in antifungal defences is much less understood.In this study, we identified a population of migrating CD43+ monocytes in cells isolated from rat distal lungs. These cells phenotypically different from alveolar macrophages, showed clearly distinct locomotory behaviour on the surface of primary alveolar cells resembling previously described endothelial patrolling. The CD43+ monocytes internalized live A.fumigatus conidia resulting in inhibition of conidial germination and hyphal growth. Thus, migrating lung monocytes might play an important role in local defence against pulmonary pathogens.

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