Evidence that fasting can induce a selective loss of uncoupling proteins from brown adipose tissue mitochondria of mice

1986 ◽  
Vol 6 (10) ◽  
pp. 931-931
Author(s):  
P. Trayhurn ◽  
G. Jennings
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Proteins ◽  
Selective Loss ◽  
Brown Adipose

Evidence that fasting can induce a selective loss of uncoupling protein from brown adipose tissue mitochondria of mice

1986 ◽  
Vol 6 (9) ◽  
pp. 805-810 ◽  
Author(s):  
P. Trayhurn ◽  
G. Jennings
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cytochrome Oxidase ◽  
Oxidase Activity ◽  
Uncoupling Protein ◽  
Cytochrome Oxidase Activity ◽  
Selective Loss ◽  
Brown Adipose ◽  
Fasting And Refeeding ◽  
Total Tissue

The effects of fasting and refeeding on the concentration of uncoupling protein in brown adipose tissue mitochondria have been investigated in mice. Fasting mice for 48 h led to a large decrease in the total cytochrome oxidase activity of the interscapular brown fat pad. Mitochondrial GDP binding and the specific mitochondrial concentration of uncoupling protein also fell on fasting. After 24 h refeeding both GDP binding and the mitochondrial concentration of uncoupling protein were normalized, but there was no alteration in the total tissue cytochrome oxidase activity. Fasting appears to induce a selective loss of uncoupling protein from brown adipose tissue mitochondria, which is rapidly reversible on refeeding.

Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog

2003 ◽  
Vol 95 (6) ◽  
pp. 2408-2415 ◽  
Author(s):  
Yoriko Masuda ◽  
Satoshi Haramizu ◽  
Kasumi Oki ◽  
Koichiro Ohnuki ◽  
Tatsuo Watanabe ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Weight ◽  
Adipose Tissue ◽  
Single Dose ◽  
Thyroid Hormones ◽  
Brown Adipose Tissue ◽  
Uncoupling Proteins ◽  
Brown Adipose ◽  
Pepper Cultivar ◽  
Ucp2 Mrna

Capsiate is a nonpungent capsaicin analog, a recently identified principle of the nonpungent red pepper cultivar CH-19 Sweet. In the present study, we report that 2-wk treatment of capsiate increased metabolic rate and promoted fat oxidation at rest, suggesting that capsiate may prevent obesity. To explain these effects, at least in part, we examined uncoupling proteins (UCPs) and thyroid hormones. UCPs and thyroid hormones play important roles in energy expenditure, the maintenance of body weight, and thermoregulation. Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue. This dose of capsiate did not change serum triiodothyronine or thyroxine levels. A single dose of capsiate temporarily raised both UCP1 mRNA in brown adipose tissue and UCP3 mRNA in skeletal muscle. These results suggest that UCP1 and UCP2 may contribute to the promotion of energy metabolism by capsiate, but that thyroid hormones do not.

Intrauterine food restriction alters the expression of uncoupling proteins in brown adipose tissue of rat newborns

2012 ◽  
Vol 37 (2) ◽  
pp. 138-143 ◽  
Author(s):  
Thais L.V. Souza ◽  
Carolina T. Coelho ◽  
Paola B. Guimarães ◽  
Eduardo M. Goto ◽  
Sylvia Maria A. Silva ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Food Restriction ◽  
Uncoupling Proteins ◽  
Brown Adipose

Effects of IL-15 on Rat Brown Adipose Tissue: Uncoupling Proteins and PPARs

Obesity ◽  
2008 ◽  
Vol 16 (2) ◽  
pp. 285-289 ◽  
Author(s):  
Vanessa Almendro ◽  
Gemma Fuster ◽  
Sílvia Busquets ◽  
Elisabet Ametller ◽  
Maite Figueras ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Uncoupling Proteins ◽  
Brown Adipose
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