Small bowel neoplasm is extremely rare, a reason for which it has a limited knowledge and understanding. Very few things are known about its etiology. Yet a high risk to develop a small bowel cancer was noted for patients with Crohn’s disease, celiac disease, familial adenomatous polyposis, and Peutz-Jeghers syndrome. A few modifiable risk factors were incriminated, such as the consumption of smoked meat, saturated fats, obesity and smoking, which also increase the incidence of small bowel neoplasm. Thus, it was observed that more considerable research is required, as well as more consistent statistical data, to understand better the etiology and biology of this type of cancer. We need to mention that a higher commitment from the family doctor is needed in the prevention and dispensarization of this pathology.