scholarly journals Tumor-specific granulocyte/macrophage colony-stimulating factor and interferon ? secretion is associated with in vivo therapeutic efficacy of activated tumor-draining lymph node cells

1995 ◽  
Vol 41 (5) ◽  
pp. 317-324 ◽  
Author(s):  
Atsushi Aruga ◽  
Suyu Shu ◽  
Alfred E. Chang
Keyword(s):  
Lymph Node ◽  
Therapeutic Efficacy ◽  
Colony Stimulating Factor ◽  
Lymph Node Cells ◽  
Draining Lymph Node ◽  
Macrophage Colony Stimulating Factor ◽  
Tumor Draining Lymph Node ◽  
Macrophage Colony ◽  
Stimulating Factor

scholarly journals Therapeutic Efficacy of Human Macrophage Colony-Stimulating Factor, Used Alone and in Combination with Antifungal Agents, in Mice with Systemic Candida albicans Infection

2000 ◽  
Vol 44 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Tetsuya Kuhara ◽  
Katsuhisa Uchida ◽  
Hideyo Yamaguchi
Keyword(s):  
Candida Albicans ◽  
Therapeutic Efficacy ◽  
Hyphal Growth ◽  
Human Macrophage ◽  
Colony Stimulating Factor ◽  
Phagocytic Cells ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

ABSTRACT We examined the in vivo activity of human macrophage colony-stimulating factor (hM-CSF) against lethal Candida albicans infection in mice. In C. albicans-infected mice which had been immunosuppressed with cyclophosphamide, treatment with hM-CSF at a daily dose of 8 × 105 units/kg of body weight or greater slightly but significantly prolonged survival. Furthermore, the therapeutic efficacy of amphotericin B (AMPH-B) in infected mice was enhanced by its combined use with hM-CSF, while that of fluconazole (FLCZ) was not. The activities of peritoneal macrophages and neutrophils from mice administered hM-CSF plus AMPH-B in combination for inhibition of hyphal growth of C. albicanscells and intracellular phagocytosis and killing of the cells were greater than those of comparable phagocytic cells from control mice to which hM-CSF plus AMPH-B was not administered. These results suggest that intravenous administration of hM-CSF augments the efficacy of AMPH-B by enhancing the antifungal activities of macrophages and neutrophils. Therefore, it is expected that therapy with the combination AMPH-B and hM-CSF could improve the efficacy of AMPH-B and reduce the therapeutic dose of the antifungal drug that is required.

In vivo effects of macrophage colony-stimulating factor on human monocyte function

1991 ◽  
Vol 77 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Asim Khwaja ◽  
Beryl Johnson ◽  
Ian E. Addison ◽  
Kwee Yong ◽  
Karen Ruthven ◽  
...  
Keyword(s):  
Human Monocyte ◽  
Colony Stimulating Factor ◽  
Monocyte Function ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
In Vivo Effects ◽  
Stimulating Factor

Granulocyte-macrophage colony-stimulating factor (GM-CSF) increases plasma fibrinolytic activity in vivo

1994 ◽  
Vol 8 (1) ◽  
pp. 42-47 ◽  
Author(s):  
K.L. Yong ◽  
T. McNally ◽  
I.J. Mackie ◽  
H. Cohen ◽  
S.J. Machin ◽  
...  
Keyword(s):  
Fibrinolytic Activity ◽  
Colony Stimulating Factor ◽  
Gm Csf ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

scholarly journals Enhanced survival but reduced engraftment in murine recipients of recombinant granulocyte/macrophage colony-stimulating factor following transplantation of T-cell-depleted histoincompatible bone marrow

Blood ◽  
1988 ◽  
Vol 72 (4) ◽  
pp. 1148-1154 ◽  
Author(s):  
BR Blazar ◽  
MB Widmer ◽  
CC Soderling ◽  
S Gillis ◽  
DA Vallera
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Hematological Parameters ◽  
Donor Cell ◽  
Colony Stimulating Factor ◽  
Murine Bone Marrow ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor

Abstract In vivo administration of murine recombinant granulocyte/macrophage colony stimulating factor (rGM-CSF) was evaluated for effects on survival and engraftment in an allogeneic murine bone marrow transplantation (BMT) model involving T-cell depletion of donor marrow. The model provides a high incidence of graft failure/rejection. Recipients of continuous subcutaneous infusions of rGM-CSF had a significant survival advantage when compared with untreated controls. However, a significantly lower incidence of donor cell engraftment was noted. Hematological parameters were not substantially affected. When rGM-CSF was administered intraperitoneally (IP), twice daily injections closely approximated the effects of continuous infusion on survival. Single IP injections were without significant effects on survival or engraftment. These results demonstrate that prolonged frequent in vivo exposure to rGM-CSF can significantly improve survival but significantly decreases donor cell repopulation in recipients of T-cell- depleted histoincompatible marrow grafts.

In vivo metabolic response of hepatic nonparenchymal cells and leukocytes to granulocyte-macrophage colony-stimulating factor

1992 ◽  
Vol 51 (4) ◽  
pp. 360-365 ◽  
Author(s):  
Zoltan Spolarics ◽  
Agnes Schuler ◽  
Gregory J. Bagby ◽  
Charles H. Lang ◽  
Steve Nelson ◽  
...  
Keyword(s):  
Metabolic Response ◽  
Colony Stimulating Factor ◽  
Nonparenchymal Cells ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Hepatic Nonparenchymal Cells ◽  
Stimulating Factor
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