Supercritical fluids show great potential as future coolants for nuclear reactors, thermal power, and solar power plants. Compared to the subcritical condition, supercritical fluids show advantages in heat transfer due to thermodynamic properties near the critical point. A specific field of interest is an innovative decay heat removal system for nuclear power plants, which is based on a turbine-compressor system with supercritical CO2 as the working fluid. In case of a severe accident, this system converts the decay heat into excess electricity and low-temperature waste heat, which can be emitted to the ambient air. To guarantee the retrofitting of this decay heat removal system into existing nuclear power plants, the heat exchanger (HE) needs to be as compact and efficient as possible. Therefore, a diffusion-bonded plate heat exchanger (DBHE) with mini channels was developed and manufactured. This DBHE was tested to gain data of the transferable heat power and the pressure loss. A multipurpose facility has been built at Institut für Kernenergetik und Energiesysteme (IKE) for various experimental investigations on supercritical CO2, which is in operation now. It consists of a closed loop where the CO2 is compressed to supercritical state and delivered to a test section in which the experiments are run. The test facility is designed to carry out experimental investigations with CO2 mass flows up to 0.111 kg/s, pressures up to 12 MPa, and temperatures up to 150 °C. This paper describes the development and setup of the facility as well as the first experimental investigation.