Mapping of the genes of some components of the electron transport chain (complex I) on the X chromosome of mammals

1982 ◽  
Vol 8 (6) ◽  
pp. 691-707 ◽  
Author(s):  
Camilla E. Day ◽  
Immo E. Scheffler
Keyword(s):  
Electron Transport ◽  
X Chromosome ◽  
Complex I ◽  
Electron Transport Chain ◽  
Chain Complex ◽  
Transport Chain

scholarly journals Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

Cancer Cell ◽  
2019 ◽  
Vol 36 (1) ◽  
pp. 84-99.e8 ◽  
Author(s):  
Irène Baccelli ◽  
Yves Gareau ◽  
Bernhard Lehnertz ◽  
Stéphane Gingras ◽  
Jean-François Spinella ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Electron Transport ◽  
Complex I ◽  
Myeloid Leukemia ◽  
Electron Transport Chain ◽  
Chain Complex ◽  
Transport Chain ◽  
Acute Myeloid

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of Oxphos Dependency in Acute Myeloid Leukemia

2019 ◽  
Author(s):  
Irene Baccelli ◽  
Yves Gareau ◽  
Bernhard Lehnertz ◽  
Stéphane Gingras ◽  
Jean-François Spinella ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Electron Transport ◽  
Complex I ◽  
Myeloid Leukemia ◽  
Electron Transport Chain ◽  
Chain Complex ◽  
Transport Chain ◽  
Acute Myeloid

scholarly journals Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

2019 ◽  
Author(s):  
Irène Baccelli ◽  
Yves Gareau ◽  
Bernhard Lehnertz ◽  
Stéphane Gingras ◽  
Jean-François Spinella ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Electron Transport ◽  
Complex I ◽  
Myeloid Leukemia ◽  
Electron Transport Chain ◽  
Chain Complex ◽  
Mitochondrial Activity ◽  
Selective Toxicity ◽  
Transport Chain ◽  
Acute Myeloid

AbstractInhibition of oxidative phosphorylation (OXPHOS) is a promising therapeutic strategy in Acute Myeloid Leukemia (AML), but patients respond heterogeneously. Through chemically interrogation of 200 sequenced specimens, we identified Mubritinib as a strong in vitro and in vivo anti-leukemic compound, acting through ubiquinone-dependent inhibition of Electron Transport Chain complex I (ETC1). ETC1 targeting showed selective toxicity against a subgroup of chemotherapy-resistant leukemias exhibiting OXPHOS hyperactivity, high expression of mitochondrial activity-related genes, and mutations affecting NPM1, FLT3 and DNMT3A. Altogether, our work thus identifies a novel ETC1 inhibitor with high clinical potential and reveals the landscape of OXPHOS dependency in AML.

scholarly journals Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation

Cell Research ◽  
2011 ◽  
Vol 21 (5) ◽  
pp. 817-834 ◽  
Author(s):  
Seonmin Lee ◽  
Eunyoung Tak ◽  
Jisun Lee ◽  
MA Rashid ◽  
Michael P Murphy ◽  
...  
Keyword(s):  
Electron Transport ◽  
Complex I ◽  
Electron Transport Chain ◽  
Chain Complex ◽  
Muscle Differentiation ◽  
Transport Chain
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