Role of gastric mucosal pepsin in the pathogenesis of acute stress ulceration

1979 ◽  
Vol 3 (2) ◽  
pp. 215-220 ◽  
Author(s):  
Yukio Nagamachi ◽  
Takuji Nakamura
Keyword(s):  
Acute Stress ◽  
Stress Ulceration

scholarly journals Environmental enrichment prevents the late effect of acute stress-induced fear extinction deficit: the role of hippocampal AMPA-GluA1 phosphorylation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leonardo Santana Novaes ◽  
Letícia Morais Bueno-de-Camargo ◽  
Carolina Demarchi Munhoz
Keyword(s):  
Environmental Enrichment ◽  
Basolateral Amygdala ◽  
Acute Stress ◽  
Fear Memory ◽  
Fear Extinction ◽  
Post Traumatic Stress ◽  
Related Disorder ◽  
Memory Extinction ◽  
Post Traumatic

AbstractThe persistence of anxiety and the deficit of fear memory extinction are both phenomena related to the symptoms of a trauma-related disorder, such as post-traumatic stress disorder (PTSD). Recently we have shown that single acute restraint stress (2 h) in rats induces a late anxiety-related behavior (observed ten days after stress), whereas, in the present work, we found that the same stress impaired fear extinction in animals conditioned ten days after stress. Fourteen days of environmental enrichment (EE) prevented the deleterious effect of stress on fear memory extinction. Additionally, we observed that EE prevented the stress-induced increase in AMPA receptor GluA1 subunit phosphorylation in the hippocampus, but not in the basolateral amygdala complex and the frontal cortex, indicating a potential mechanism by which it exerts its protective effect against the stress-induced behavioral outcome.

116. The functional role of exosome associated extracellular heat shock protein 72 following exposure to acute stress

2012 ◽  
Vol 26 ◽  
pp. S32-S33 ◽  
Author(s):  
L.A. Beninson ◽  
T. Maslanik ◽  
M.J. Murphy ◽  
M. Fleshner
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Functional Role ◽  
Acute Stress ◽  
Heat Shock Protein 72

Role of mast cells in rectal hypersensitivity by acute stress in rats

2003 ◽  
Vol 124 (4) ◽  
pp. A682
Author(s):  
Yaozong Yuan ◽  
Yanbin Liu ◽  
Ranjun Tao
Keyword(s):  
Mast Cells ◽  
Acute Stress ◽  
Rectal Hypersensitivity

Acute Stress Induced Behavioral Deficits In Rats: Relationship With Oxidative Stress, Leptin And HPA Axis

2019 ◽  
Vol 41 (5) ◽  
pp. 859-859
Author(s):  
Erum Shireen Erum Shireen ◽  
Wafa Binte Ali Wafa Binte Ali ◽  
Maria Masroor Maria Masroor ◽  
Saeeda Bano Saeeda Bano ◽  
Samina Iqbal Samina Iqbal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Open Field ◽  
Hpa Axis ◽  
Acute Stress ◽  
Antioxidant Properties ◽  
Oxidative Enzymes ◽  
Behavioral Deficits ◽  
Glucose Estimation ◽  
Dark Transition

Acute exposure to stress is connected to many disorders that promote the toxicity of oxygen radical generators leading to increase in the levels of enzymes and also the activation of the HPA axis. The present study uses a preclinical approach to elucidate some prospective stress-induced behavioral and biochemical effects. The aim of current study was to investigate the relationship between stress and behavioral changes after exposing animals to 2h immobilization stress. We also evaluated the concentration of corticosterone, glucose and endogenous leptin levels in unstressed and stressed animals to explore the possible role of HPA axis in the modulation of stressed induced behavioral deficits. Rats were divided into stressed and unstressed groups. Behavioral activities were monitored in open field activity and light dark transition box after the termination of 2h immobilization period. Animals were then decapitated and plasma samples were collected for catalase, SOD, corticosterone, and glucose estimation. Results showed that exposure to acute stress produced a significant decrease in the activity of rats in the novel environment (open field) and light dark transition box. On the other hand, concomitant elevated level of peripheral markers of oxidative stress such as oxidative enzymes, corticosterone and endogenous leptin were also observed. Therefore, current study seems to suggest an important role of compounds having antioxidant properties for the treatment of stress and related disorders.

scholarly journals Unexpected role of physiological estrogen in acute stress-induced memory deficits

2020 ◽  
pp. JN-RM-2146-20
Author(s):  
Rachael E. Hokenson ◽  
Annabel K. Short ◽  
Yuncai Chen ◽  
Aidan L. Pham ◽  
Emily T. Adams ◽  
...  
Keyword(s):  
Acute Stress ◽  
Memory Deficits

scholarly journals Effect of Acute Mental Stress on Heart Rate and QT Variability in Postmyocardial Infarction Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Damiano Magrì ◽  
Gianfranco Piccirillo ◽  
Raffaele Quaglione ◽  
Annalaura Dell’Armi ◽  
Marilena Mitra ◽  
...  
Keyword(s):  
Acute Stress ◽  
Management Strategies ◽  
Low Frequency ◽  
Frequency Component ◽  
Postmyocardial Infarction ◽  
Increased Risk ◽  
Qt Variability Index ◽  
Qt Variability ◽  
Variability Index

Emotionally charged events are associated with an increased risk of sudden cardiac death (SCD). In this study we assessed RR and QT variability index (QTVI) at baseline during anger recall test (AR). We calculated QTVI from a 5-min ECG recording and from a 10-beats segment around the presumed maximum sympathetic activation in thirty post-myocardial infarction patients under β-blocker therapy and 10 controls underwent. In all groups, the low-frequency component of RR and SBP increased during AR. In all recordings, the QTVI calculated on a 5-min ECG recording and the were higher in patients than in controls (P < 0.05). The QTVI during AR remained unchanged from baseline within each group. Conversely, during AR, the in controls diminished significantly (P < 0.05) from baseline whereas in patients remained unchanged. The inability to buffer an acute stress-induced increase in sympathetic activity could explain why events charged with acute stress are associated with an increased risk of ventricular arrhythmias in this setting of patients and support the role of cognitive behavior stress management strategies.

The Role of Coding and Regulatory RNAs during Acute Stress

2020 ◽  
Vol 35 (3) ◽  
pp. 129-133
Author(s):  
I. B. Filippenkov ◽  
L. V. Dergunova
Keyword(s):  
Acute Stress ◽  
Regulatory Rnas

scholarly journals The role of copeptin as a novel cardiovascular biomarker

2015 ◽  
Vol 24 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Andy Kristyagita ◽  
Bambang B. Siswanto
Keyword(s):  
Acute Stress ◽  
Main Function ◽  
Testing Methods ◽  
Mortality And Morbidity ◽  
Pathological Conditions ◽  
Potential Biomarker ◽  
Molecular Stability ◽  
Electrolyte Homeostasis ◽  
Cardiovascular Biomarker

Copeptin is a provasopressin-derived peptide, the precursor for arginine vasopressin (AVP), which is an antidiuretic hormone from the hypothalamus. Copeptin is secreted together with AVP equally as a response of AVP stimulation. While AVP’s main function is water and blood volume regulation and maintaining electrolyte homeostasis, copeptin’s function is still not fully understood. AVP, copeptin, and other vasopressinergic neuropeptides’ levels are elevated in acute stress caused by pathological conditions. Clinical use of AVP levels has many weaknesses. Copeptin can act as a replacement because of its molecular stability, easier testing methods, and faster results. For example, combination of copeptin and cardiac troponins can eliminate myocardial infarction (MI) diagnosis faster, while combined with brain-type natriuretic peptide (BNP) or its precursor can predict heart failure (HF) outcome. In cardiovascular shock, copeptin levels are elevated. As such, copeptin is a potential biomarker for MI diagnosis and predictor for HF mortality and morbidity. 

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